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NF-kappaB signaling pathways in Neurological inflammation: A mini review

Frontiers in Molecular Neuroscience, 2015
The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism for the cells in response to a wide variety of stimuli linking to ...
Ruey-Horng eShih, Chen -Yu eWang, Chuen-Mao eYang   +2 more
doaj   +1 more source

APOBEC3C‐Mediated NF‐κB Activation Promotes Malignant Progression of Gliomas

Immunity, Inflammation and Disease
Objective To analyze the clinicopathological features, immunological characteristics, and prognostic value of APOBEC3C in gliomas, and to verify the specific mechanism by which it mediates the malignant progression of gliomas.
Chao Zhang, Tao Yang, Yuhang Tang, Dong Yu, Shiqiang Hou, Ning Lin, Qun Li   +6 more
doaj   +1 more source

Yangonin Blocks Tumor Necrosis Factor-α–Induced Nuclear Factor-κB–Dependent Transcription by Inhibiting the Transactivation Potential of the RelA/p65 Subunit

Journal of Pharmacological Sciences, 2012
The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and apoptosis. In our search for NF-κB inhibitors from natural resources, we identified yangonin from Piper methysticum as an ...
Juan Ma, He Liang, Hong Ri Jin, Nguyen Tien Dat, Shan Yu Zhang, Ying Zi Jiang, Ji Xing Nan, Donghao Li, Xue Wu, Jung Joon Lee, Xuejun Jin   +10 more
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Plumbagin Suppresses the Invasion of HER2-Overexpressing Breast Cancer Cells through Inhibition of IKKα-Mediated NF-κB Activation.

PLoS ONE, 2016
HER2-overexpressing breast cancers account for about 30% of breast cancer occurrences and have been correlated with increased tumor aggressiveness and invasiveness.
Anna Kawiak, Anna Domachowska
doaj   +1 more source

Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode

Cancer Biology & Medicine, 2017
The role of the transcription factor NF-κB in shaping the cancer microenvironment is becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF-κB function, and causes extensive changes in genomic chromatin that ultimately ...
Spiros A. Vlahopoulos
doaj   +1 more source

NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug

Journal of Translational Medicine, 2012
Background Most DNA-damaging chemotherapeutic agents activate the transcription factor nuclear factor κB (NF-κB). However, NF-κB activation can either protect from or contribute to the growth suppressive effects of the agent.
Caporali Simona, Levati Lauretta, Graziani Grazia, Muzi Alessia, Atzori Maria Grazia, Bonmassar Enzo, Palmieri Giuseppe, Ascierto Paolo A, D’Atri Stefania   +8 more
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NF-κB is a central regulator of hypoxia-induced gene expression

EMBO Reports
Hypoxia is both a physiological and pathological signal in cells. Changes in gene expression play a critical role in the cellular response to hypoxia, enabling cells to adapt to reduced oxygen availability. These changes are primarily mediated by the HIF
Dilem Shakir, Michael Batie, Chun-Sui Kwok, Simon J Cook, Niall S Kenneth, Sonia Rocha   +5 more
doaj   +1 more source

The impact of astrocytic NF-κB on healthy and Alzheimer’s disease brains

Scientific Reports
Astrocytes play a role in healthy cognitive function and Alzheimer’s disease (AD). The transcriptional factor nuclear factor-κB (NF-κB) drives astrocyte diversity, but the mechanisms are not fully understood.
Tee Jong Huat, Judith Camats-Perna, Estella A. Newcombe, Tessa Onraet, Daniel Campbell, Josiah T. Sucic, Alessandra Martini, Stefânia Forner, Mehdi Mirzaei, Wayne Poon, Frank M. LaFerla, Rodrigo Medeiros   +11 more
doaj   +1 more source

Real-Time Monitoring of Nuclear Factor κB Activity in Cultured Cells and in Animal Models

Molecular Imaging, 2009
Nuclear factor κB (NF-κB) is a transcription factor that plays a major role in many human disorders, including immune diseases and cancer. We designed a reporter system based on NF-κB responsive promoter elements driving expression of the secreted ...
Christian E. Badr, Johanna M. Niers, Lee-Ann Tjon-Kon-Fat, David P. Noske, Thomas Wurdinger, Bakhos A. Tannous   +5 more
doaj   +1 more source

The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity

Frontiers in Pharmacology
IntroductionNuclear factor kappa B (NF-κB) is a key regulator of immune and inflammatory responses. Glucocorticoid drugs (GC) act through the glucocorticoid receptor (GR) as immunosuppressant also in pediatric patients inhibiting NF-κB activity. The long
Debora Curci, Biljana Stankovic, Nikola Kotur, Letizia Pugnetti, Vladimir Gasic, Maurizio Romano, Branka Zukic, Giuliana Decorti, Gabriele Stocco, Gabriele Stocco, Marianna Lucafò, Sonja Pavlovic   +11 more
doaj   +1 more source