NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
Frontiers in Oncology, 2023 IntroductionImproving treatments for Diffuse Large B-Cell Lymphoma (DLBCL) is challenged by the vast heterogeneity of the disease. Nuclear factor-κB (NF-κB) is frequently aberrantly activated in DLBCL. Transcriptionally active NF-κB is a dimer containing
Eleanor Jayawant +8 more
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NF‐κB signaling in inflammation and cancer
MedComm, 2021 Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered in 1986, extraordinary efforts have been made to understand the function and regulating mechanism of NF‐κB for 35 years, which lead to significant progress ...
Tao Zhang +4 more
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Hepatology Communications, 2021 Drug‐induced hepatotoxicity limits development of new effective medications. Drugs and numerous endogenous/exogenous agents are metabolized/detoxified by hepatocytes, during which reactive oxygen species (ROS) are generated as a by‐product. ROS has broad
Xiao Zhong +7 more
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Extracellular flux analysis to investigate the impact of NF-κB on mitochondrial respiration in colorectal carcinoma (CRC). [PDF]
, 2021 The reprogramming of cell metabolism is a hallmark of cancer. NF-κB transcription factors coordinate the host defense responses to stress, injury, and infection. They also play a central role in oncogenesis, at least in part by regulating cell metabolism
Zazzeroni, F +23 more
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Tiliroside Produced Anti-Neuroinflammatory Effects Through Interference With NF-κB And MAPK Signalling In LPS+ IFN-γ Stimulated BV-2 Microglia. [PDF]
, 2014 Tiliroside is a glycosidic flavonoid, which possesses anti-inflammatory, antioxidant, anticarcinogenic and hepatoprotective activities. It is contained in several dietary plants like linden, rosehip, raspberry and strawberry [1, 2].
Aderogba, Mutallib A. +2 more
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Immunity, Inflammation and Disease, 2023 Objective In this study, the therapeutic effect of quinic acid (QA), which has anti‐inflammatory activity, was investigated on acetic acid‐induced colitis in male Wistar rats.
Maryam Ghasemi‐Dehnoo +4 more
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NF-kB decoy oligodeoxynucleotide preserves disc height in a rabbit anular-puncture model and reduces pain induction in a rat xenograft-radiculopathy model [PDF]
European Cells & Materials, 2021 While it is known that the degenerated intervertebral disc (IVD) is one of the primary reasons for low-back pain and subsequent need for medical care, there are currently no established effective methods for direct treatment. Nuclear factor-κB (NF-κB) is
K Kato +12 more
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NF-kappa B activation correlates with disease phenotype in Crohn's disease. [PDF]
PLoS ONE, 2017 Unregulated activation of nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of Crohn's disease. In this study, we investigated the clinical characteristics and disease outcome of Crohn's disease patients with varying levels of the NF-κB
Yoo Min Han +8 more
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Sensitivity analysis and experimental design of a stiff signal transduction pathway model [PDF]
, 2007 Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2].
Yue, H. +4 more
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Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions
Cells, 2016 The family of NF-κB transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development.
Véronique Baud, Davi Collares
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