Results 41 to 50 of about 215,949 (91)
Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain
Journal of Neuroinflammation, 2019 Background While NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging-associated microglial pro-inflammatory priming is poorly understood ...
Thomas Taetzsch +4 more
doaj +1 more source
CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein [PDF]
, 2018 The use of alternative promoters for the cell type-specific expression of a given mRNA/protein is a common cell strategy. NEMO is a scaffold protein required for canonical NF-κB signaling.
Babaei, Milad +7 more
core +1 more source
Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]
, 2014 Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
An +48 more
core +5 more sources
Blood Advances: Early detection of ultrahigh-risk diffuse large B-cell lymphoma (DLBCL) is an unmet medical need to aid patient stratification for alternative treatment approaches.
Aurélie Montagne +18 more
doaj +1 more source
The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability
Frontiers in Immunology, 2019 Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology.
Emilie Ronin +10 more
doaj +1 more source
Cell Death and DiseaseCellular responses to TNF are inherently heterogeneous within an isogenic cell population and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF-κB and MAPK signalling pathways but may also trigger apoptosis and ...
Marcus K. Preedy +2 more
doaj +1 more source
BiomedicinesBackground: Gastric cancer (GC) is a highly heterogeneous disease and remains one of the major causes of cancer-related mortality worldwide. The vast majority of GC cases are adenocarcinomas including diffuse and intestinal GC that may differ in their ...
Cynthia Pimpie +4 more
doaj +1 more source
In Vivo Zonal Variation and Liver Cell-Type Specific NF-κB Localization after Chronic Adaptation to Ethanol and following Partial Hepatectomy. [PDF]
PLoS ONE, 2015 NF-κB is a major inflammatory response mediator in the liver, playing a key role in the pathogenesis of alcoholic liver injury. We investigated zonal as well as liver cell type-specific distribution of NF-κB activation across the liver acinus following ...
Harshavardhan Nilakantan +4 more
doaj +1 more source
New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks
Biology, 2023 The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation.
Dominga Iacobazzi +5 more
doaj +1 more source
Effect of Aqueous Ozone on the NF-κB System [PDF]
, 2007 Ozone has been proposed as an alternative oral antiseptic in dentistry, due to its antimicrobial power reported for gaseous and aqueous forms, the latter showing a high biocompatibility with mammalian cells.
Brand, K. +8 more
core +1 more source