Results 51 to 60 of about 574,970 (229)

NF-κB affects E-box-mediated transcription.

, 2021
Steady-state luciferase reporter assay in transiently transfected 293T cells. (A) NF-κB itself, in the absence of BMAL1/CLOCK (B/C), did not activate the E-box transcription from the 3xE-box::Luc or Per2-dLuc reporters (left, middle), but repressed BMAL1/
Yang Shen (66591), Carrie L. Partch (1980499), David W. Hammers (3357035), Zhiguang Huo (785658), Wei Wang (17594), Andrew R. Morris (10090727), Lauren J. Francey (9270960), John B. Hogenesch (149244), Mehari Endale (11740641), Rachel L. Harold (11740644), Zhao-Hui Wu (8159670), Andrew C. Liu (11740647)   +11 more
core   +1 more source

Involvement of Hormone Receptors, Membrane Receptors and Signaling Pathways in European Gastric Cancers Regarding Subtypes and Epigenetic Alterations: A Pilot Study

Biomedicines
Background: Gastric cancer (GC) is a highly heterogeneous disease and remains one of the major causes of cancer-related mortality worldwide. The vast majority of GC cases are adenocarcinomas including diffuse and intestinal GC that may differ in their ...
Cynthia Pimpie, Anne Schninzler, Marc Pocard, Véronique Baud, Martine Perrot-Applanat   +4 more
doaj   +1 more source

New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks

Biology, 2023
The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation.
Dominga Iacobazzi, Paolo Convertini, Simona Todisco, Anna Santarsiero, Vito Iacobazzi, Vittoria Infantino   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

An unexpected twist to the activation of IKKβ:TAK1 primes IKKβ for activation by autophosphorylation [PDF]

, 2014
IKKß {IkB [inhibitor of NF-?B (nuclear factor ?B)] kinase ß} is required to activate the transcription factor NF-?B, but how IKKß itself is activated in vivo is still unclear.
Lawrence, T., Peggie, M. W., Lawrence, Toby, Peggie, Mark W., Clark, Kristopher, Cohen, P., Cohen, Philip; id_orcid, Clark, K., Zhang, Jiazhen, Zhang, J.   +9 more
core   +1 more source

Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism

Viruses, 2018
Nuclear factor-κB (NF-κB) is an important transcription factor that induces the expression of antiviral genes and viral genes. NF-κB activation needs the activation of NF-κB upstream molecules, which include receptors, adaptor proteins, NF-κB (IκB ...
Liyao Deng, Qiurui Zeng, Mingshu Wang, Anchun Cheng, Renyong Jia, Shun Chen, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Xinxin Zhao, Shaqiu Zhang, Yunya Liu, Yanling Yu, Ling Zhang, Xiaoyue Chen   +15 more
doaj   +1 more source

In Vivo Zonal Variation and Liver Cell-Type Specific NF-κB Localization after Chronic Adaptation to Ethanol and following Partial Hepatectomy. [PDF]

PLoS ONE, 2015
NF-κB is a major inflammatory response mediator in the liver, playing a key role in the pathogenesis of alcoholic liver injury. We investigated zonal as well as liver cell type-specific distribution of NF-κB activation across the liver acinus following ...
Harshavardhan Nilakantan, Lakshmi Kuttippurathu, Austin Parrish, Jan B Hoek, Rajanikanth Vadigepalli   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Modulation of granulocyte-endothelium interactions by antileukoproteinase : inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium [PDF]

, 2006
Antileukoproteinase (ALP) is a physiological inhibitor of granulocytic serine proteases that has been shown to have anti-inflammatory properties in addition to its antiproteolytic activity.
Rikard Holmdahl, Kutty Nandakumar, Vollmar, Brigitte,, Sehnert, Bettina,, Harald Burkhardt, Rupert Hallmann, Hallmann, Rupert,, Anja Kühl, Reinhard Voll, Ibrahim, Saleh, Nandakumar, Kutty Selva,, Holmdahl, Rikard, Voll, Reinhard,, Burkhardt, Harald,, Gierer, Philip,, Bettina Sehnert, Burkhardt, Harald, Hallmann, Rupert, Saleh Ibrahim, Nandakumar, Kutty Selva, Vollmar, Brigitte, Ibrahim, Saleh,, Kühl, Anja,, Kuehl, Anja, Sehnert, Bettina, Philip Gierer, Gierer, Philip, Kühl, Anja, Lund University., Voll, Reinhard, Holmdahl, Rikard,, Brigitte Vollmar   +31 more
core   +1 more source

The NF-κB Genomic Landscape in Lymphoblastoid B Cells

Cell Reports, 2014
The nuclear factor κB (NF-κΒ) subunits RelA, RelB, cRel, p50, and p52 are each critical for B cell development and function. To systematically characterize their responses to canonical and noncanonical NF-κB pathway activity, we performed chromatin ...
Bo Zhao, Luis A. Barrera, Ina Ersing, Bradford Willox, Stefanie C.S. Schmidt, Hannah Greenfeld, Hufeng Zhou, Sarah B. Mollo, Tommy T. Shi, Kaoru Takasaki, Sizun Jiang, Ellen Cahir-McFarland, Manolis Kellis, Martha L. Bulyk, Elliott Kieff, Benjamin E. Gewurz   +15 more
doaj   +1 more source