Results 71 to 80 of about 599,996 (240)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery, yet their clinical utility is limited by an acute inflammatory response post‐administration. LNP‐associated inflammation (LAI) manifests as de novo inflammation in select organs (e.g.,
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
doaj   +1 more source

LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation.

PLoS ONE, 2011
BackgroundNuclear factor κB (NF-κB)-mediated pathways have been widely implicated in cell survival, development and tumor progression. Although the molecular events of determining NF-κB translocation from cytoplasm to nucleus have been extensively ...
Zhiqiang Wu, Yazhuo Li, Xiaolei Li, Dongdong Ti, Yali Zhao, Yiling Si, Qian Mei, Po Zhao, Xiaobing Fu, Weidong Han   +9 more
doaj   +1 more source

Aberrant expression of NF-κB in liver fluke associated cholangiocarcinoma: implications for targeted therapy. [PDF]

PLoS ONE, 2014
BACKGROUND: Up-regulation and association of nuclear factor kappa B (NF-κB) with carcinogenesis and tumor progression has been reported in several malignancies. In the current study, expression of NF-κB in cholangiocarcinoma (CCA) patient tissues and its
Wunchana Seubwai, Chaisiri Wongkham, Anucha Puapairoj, Narong Khuntikeo, Ake Pugkhem, Chariya Hahnvajanawong, Jariya Chaiyagool, Kazuo Umezawa, Seiji Okada, Sopit Wongkham   +9 more
doaj   +1 more source

Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study. [PDF]

, 2010
INTRODUCTION: Streptococcus pneumoniae remains a major global health problem and a leading cause of death in children worldwide. The factors that influence development of pneumococcal sepsis remain poorly understood, although increasing evidence points ...
Rautanen, Anna, Moore, CE, J Scott, Adrian VS Hill, Shelley Segal, Chiea C Khor, Andrew Walley, Catrin E Moore, Hill, AVS, Peshu, N, Davies, Robert JO, Williams, TN, Chapman, Stephen J, James A Berkley, Segal, S, Rautanen, A, Scott, J Anthony, Fredrik O Vannberg, Walley, A, Khor, Chiea C, Vannberg, Fredrik O, Davies, RJO, Khor, CC, Derrick W Crook, Crook, DW, Moore, Catrin E, Berkley, James A, Segal, Shelley, Berkley, JA, Norbert Peshu, Hill, Adrian VS, Crook, Derrick W, Thomas N Williams, Day, Nicholas P, Day, NP, Vannberg, FO, Peshu, Norbert, Chapman, SJ, Scott, JA, Stephen J Chapman, Nicholas P Day, Anna Rautanen, Williams, Thomas N, Walley, Andrew, Robert JO Davies, Crook D.W., Berkley J.A., Williams T.N., Walley A., Peshu N., Davies R.J.O., Khor C.C., Segal S., Vannberg F.O., Hill A.V.S., Day N.P., Scott J.A., Moore C.E., Rautanen A., Chapman S.J.   +59 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

NF-κB response with flow and degradation.

, 2016
(A) Representative images from confocal microscopy of NF-κB (green) and nuclear counterstain (red) following exposure to different flow times. Images were acquired at 10x magnification (scale bar = 50μm).
Scott Cooper (3373172), Karli K. McDonald (348246), Lisa Danielzak (3373175), Richard L. Leask (3373169)   +3 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Effect of pepsin in p-NF-κB nuclear localization, in human hypopharyngeal keratinocytes (HHK) and human hypopharyngeal primary cells (HHPC).

, 2016
Immunofluorescence (IF) staining of phospho-NF-κB (p-p65 S529) is demonstrated in (A) HHK and (B) HHPC treated by 0.1 mg/ml pepsin at different pH (acid, pH 4.0; weakly acidic, pH 5.0 and neutral, pH 7.0) and corresponding controls. Acidic-pepsin treated
Julia Toman (3545372), Dimitra Vageli (3545375), Clarence T. Sasaki (3545369)   +2 more
core   +1 more source