Results 91 to 100 of about 599,996 (240)
, 2016 (A and B) Representative images of NF-κb nuclear translocation and NF-κB DNA binding activity after treated with 5 μg/ml rhsCD40L for 0, 15, 30, 60 and 120 min by immunofluorescence (A) and EMSA (B).
Wei Sun (93580) +3 more
core +1 more source
NF-κB affects E-box-mediated transcription.
, 2021 Steady-state luciferase reporter assay in transiently transfected 293T cells. (A) NF-κB itself, in the absence of BMAL1/CLOCK (B/C), did not activate the E-box transcription from the 3xE-box::Luc or Per2-dLuc reporters (left, middle), but repressed BMAL1/
Yang Shen (66591) +11 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand +5 more
wiley +1 more source
NF-κB regulates neuronal ankyrin-G via a negative feedback loop.
, 2017 The axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with the cytoskeletal anchor protein ankyrin-G in immunoprecipitation and proximity-ligation ...
Jochen Prehn (7895672) +6 more
core +3 more sources
NF-κB Activation Exacerbates, but Is not Required for Murine Bmpr2-Related Pulmonary Hypertension
Diseases, 2014 Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation.
Megha Talati +9 more
doaj +1 more source
NF-κB activation in DEP-induced IL-6 and IL-8 expression in nasal fibroblasts.
, 2016 (A) Nasal fibroblasts were treated DEP (50 μg/mL) in the presence or absence of BAY117082 (NF-κB inhibitor, 1 μM). Protein expression levels of NF-κB p50 were examined using western blotting.
Jae-Min Shin (5756) +5 more
core +1 more source
, 2023 Alphaherpesvirus infection is associated with attenuation of different aspects of the host innate immune response that is elicited to confine primary infections at the mucosal epithelia.
Nicolás Romero +15 more
core +1 more source
Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali +4 more
wiley +1 more source
APOBEC3C‐Mediated NF‐κB Activation Promotes Malignant Progression of Gliomas
Immunity, Inflammation and DiseaseObjective To analyze the clinicopathological features, immunological characteristics, and prognostic value of APOBEC3C in gliomas, and to verify the specific mechanism by which it mediates the malignant progression of gliomas.
Chao Zhang +6 more
doaj +1 more source
Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley +1 more source