A role for NF-κB activity in skin hyperplasia and the development of keratoacanthomata in mice. [PDF]
PLoS ONE, 2013 Previous studies have implicated NF-κB signaling in both cutaneous development and oncogenesis. However, these studies have been limited in part by the lethality that results from extreme over- or under-expression of NF-κB in available mouse models. Even
Brian Poligone +5 more
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Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study. [PDF]
, 2010 INTRODUCTION: Streptococcus pneumoniae remains a major global health problem and a leading cause of death in children worldwide. The factors that influence development of pneumococcal sepsis remain poorly understood, although increasing evidence points ...
Rautanen, Anna +51 more
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NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes [PDF]
, 2011 NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair ...
Salles, Daniela +20 more
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Fatty Acid Metabolism Provides an Essential Survival Signal in OxPhos and BCR DLBCL Cells
BiomedicinesBackgroung/objectives: Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of malignant lymphoma and is a heterogeneous disease with various gene and chromosomal abnormalities.
Aurélie Montagne +7 more
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The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability
Frontiers in Immunology, 2019 Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology.
Emilie Ronin +10 more
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Model simplification of signal transduction pathway networks via a hybrid inference strategy [PDF]
, 2008 A full-scale mathematical model of cellular networks normally involves a large number of variables and parameters. How to effectively develop manageable and reliable models is crucial for effective computation, analysis and design of such systems.
Yue, Hong, Jia, Jianfang
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The Role of Ubiquitination in NF-κB Signaling during Virus Infection
Viruses, 2021 The nuclear factor κB (NF-κB) family are the master transcription factors that control cell proliferation, apoptosis, the expression of interferons and proinflammatory factors, and viral infection. During viral infection, host innate immune system senses
Kun Song, Shitao Li
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Neoplasia: An International Journal for Oncology Research, 2004 Aberrant nuclear factor-κB (NF-κB) activation has been implicated in the pathogenesis of several human malignancies. In this study, we determined whether NF-κB is constitutively activated in human prostate adenocarcinoma, and, if so, whether increased NF-
Sanjeev Shukla +6 more
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Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation. [PDF]
, 2012 Maternal Wnt/β-Catenin signaling establishes a program of dorsal-specific gene expression required for axial patterning in Xenopus. We previously reported that a subset of dorsally expressed genes depends not only on Wnt/β-Catenin stimulation, but also ...
Rupp, Ralph A. W. +11 more
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The Ubiquitination of NF-κB Subunits in the Control of Transcription
Cells, 2016 Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors fundamental in the control of the inflammatory response. The transcription of hundreds of genes involved in inflammation and immune homeostasis require NF-κB ...
Patricia E. Collins +2 more
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