NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes [PDF]
, 2011 NF-κB is involved in immune responses, inflammation, oncogenesis, cell proliferation and apoptosis. Even though NF-κB can be activated by DNA damage via Ataxia telangiectasia-mutated (ATM) signalling, little was known about an involvement in DNA repair ...
Salles, Daniela +20 more
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Sensitivity analysis and experimental design of a stiff signal transduction pathway model [PDF]
, 2007 Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2].
Yue, H. +4 more
core +2 more sources
Nuclear factor-kappa B inhibition can enhance apoptosis of differentiated thyroid cancer cells induced by 131I. [PDF]
PLoS ONE, 2012 OBJECTIVE: To evaluate changes of nuclear factor-kappa B (NF-κB) during radioiodine 131 ((131)I) therapy and whether NF-κB inhibition could enhance (131)I-induced apoptosis in differentiated thyroid cancer (DTC) cells in a synergistic manner.
Zhaowei Meng +5 more
doaj +1 more source
Understanding NF‐κB signaling via mathematical modeling
Molecular Systems Biology, 2008 Mammalian inflammatory signaling, for which NF‐κB is a principal transcription factor, is an exquisite example of how cellular signaling pathways can be regulated to produce different yet specific responses to different inflammatory insults. Mathematical
Raymond Cheong +2 more
doaj +1 more source
The Neutrophil Gelatinase-associated lipocalin (NGAL), a NF-kB regulated gene, is a survival factor for thyroid neoplastic cells [PDF]
, 2008 NF-κB is constitutively activated in primary human thyroid tumors, particularly in those of anaplastic type. The inhibition of NF-κB activity in the human anaplastic thyroid carcinoma cell line, FRO, leads to an increased susceptibility to ...
Iannetti, Alessio
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Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
Biomolecules, 2020 The nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor central to inflammation and various malignant diseases in humans. The regulation of NF-κB can be influenced by a myriad of post-translational modifications (PTMs), including ...
Aishat Motolani +3 more
doaj +1 more source
Kaohsiung Journal of Medical Sciences, 2012 Modulation of nuclear factor-kappa B (NF-κB) expression has important clinical implications including anti-inflammation. Recently, we have shown that direct regulation of NF-κB/p65 subunit may account for tacrolimus ointment’s remarkable clinical ...
Ching-Shuang Wu +5 more
doaj +1 more source
Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]
, 2012 Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A. +7 more
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NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity
, 2021 International audienceConventional type 1 dendritic cells (cDC1s) are critical for antitumor immunity. They acquire antigens from dying tumor cells and cross-present them to CD8 + T cells, promoting the expansion of tumor-specific cytotoxic T cells ...
Manh, Thien +30 more
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Translational Psychiatry, 2021 Bipolar disorder and schizophrenia have multiple clinical and genetic features in common, including shared risk associated with overlapping susceptibility loci in immune-related genes. Higher activity of the nuclear factor-κB (NF-κB) transcription factor
Kaitlyn M. Roman +3 more
doaj +1 more source