Results 111 to 120 of about 577,005 (273)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Relationship between TLR4 and NF-κB p65 protein expressions and clinical radiosensitivity of patientswith esophageal squamous cell carcinoma

Pakistan Journal of Medical Sciences, 2014
Objective: To study the relationship between TLR4 and NF-?B p65 protein expressions in tumor tissues after radiotherapy and clinical radiosensitivity of patients with esophageal squamous cell carcinoma.Methods: A total of 93 patients with esophageal squamous cell carcinoma first treated in our hospital by radiotherapy and surgeries from November 2010 ...
Tang, Hua, Wang, Feng, Zhou, Xi-Fa, Zhou, Jian, Chen, Ling, Luo, Ju-Dong, Xu, En-Ci   +6 more
openaire   +2 more sources

Yangonin Blocks Tumor Necrosis Factor-α–Induced Nuclear Factor-κB–Dependent Transcription by Inhibiting the Transactivation Potential of the RelA/p65 Subunit

Journal of Pharmacological Sciences, 2012
The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and apoptosis. In our search for NF-κB inhibitors from natural resources, we identified yangonin from Piper methysticum as an ...
Juan Ma, He Liang, Hong Ri Jin, Nguyen Tien Dat, Shan Yu Zhang, Ying Zi Jiang, Ji Xing Nan, Donghao Li, Xue Wu, Jung Joon Lee, Xuejun Jin   +10 more
doaj   +1 more source

NF-κB mediated the effect of GDNF on CXCL1 and proliferation in rat C6 glioma cells.

, 2023
(A) Western blot showed that NF-κB mediated the effect of exogenous GDNF on CXCL1. (B) The statistical results of (A). (C) NF-κB mediated GDNF enhanced the activity of CXCL1 gene promoter region by double luciferase reporter gene activity.
Dian Shuai Gao (16851471), Yue Wang (65477), Jin Gao (160559), Yue Wu (1262184), Shen Sun (9739508), Li Li (14993)   +5 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

NF-κB Activation Exacerbates, but Is not Required for Murine Bmpr2-Related Pulmonary Hypertension

Diseases, 2014
Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation.
Megha Talati, Haitham Mutlak, Kirk B. Lane, Wei Han, Anna Hemnes, Outi Mutlak, Tom Blackwell, Rinat Zaynagetdinov, Timothy S. Blackwell, James West   +9 more
doaj   +1 more source

NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity

, 2021
International audienceConventional type 1 dendritic cells (cDC1s) are critical for antitumor immunity. They acquire antigens from dying tumor cells and cross-present them to CD8 + T cells, promoting the expansion of tumor-specific cytotoxic T cells ...
Manh, Thien, Ghislat, Ghita, Baudoin, Elodie, Auphan-Anezin, Nathalie, Crozat, Karine, Vu Manh, Thien P., Ballester, Pedro J., Attaf, Noudjoud, Verthuy, Christophe, Malissen, Bernard, Cheema, Ammar S., Dong, Chuang, Lawrence, Toby, Cheema, Ammar, Milpied, Pierre, Ballester, Pedro, Dalod, Marc   +16 more
core   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Associations of Lifestyle‐Related Factors and Psoriatic Arthritis Disease Activity: The Dutch South West Psoriatic Arthritis Study

Arthritis Care &Research, EarlyView.
Objective This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements. Methods This multicenter cohort included 938 patients who were newly diagnosed with PsA between 2013 and 2023.
Batoul Hojeij, Ilja Tchetverikov, Marc R. Kok, Marijn Vis, Yvonne Goekoop‐Ruiterman, Jessica Bijsterbosch, Paul Baudoin, Reinhard Bos, Jos H. van der Kaap, Petra Kok, Lindy‐Anne Korswagen, Jolanda J. Luime   +11 more
wiley   +1 more source

APOBEC3C‐Mediated NF‐κB Activation Promotes Malignant Progression of Gliomas

Immunity, Inflammation and Disease
Objective To analyze the clinicopathological features, immunological characteristics, and prognostic value of APOBEC3C in gliomas, and to verify the specific mechanism by which it mediates the malignant progression of gliomas.
Chao Zhang, Tao Yang, Yuhang Tang, Dong Yu, Shiqiang Hou, Ning Lin, Qun Li   +6 more
doaj   +1 more source