Results 111 to 120 of about 525,635 (287)

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

The Effects of Curcumin on NF-κB Level and Degree of Liver Fibrosis in Rat Liver Fibrosis

Jurnal Penyakit Dalam Indonesia, 2018
Introduction. Chronic inflammation is the main mechanism responsible for liver fibrosis. NF-κB regulates inflammation, wound healing, and cell death. Curcumin acts as an antiinflammatory, antifibrotic and induced apoptosis, one of them through resistance
Supriono, Bogi Pratomo, Dedy Indra Praja
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons [PDF]

, 2013
Klenke C, Widera D, Engelen T, et al. Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons. PLoS ONE. 2013;8(6): e65280.Signaling via NF-κB in neurons depends on complex formation with interactors such as dynein/dynactin motor ...
Klenke, Christin, Kaltschmidt Christian, Christian Kaltschmidt, Thomas Noll, Christin Klenke, Karsten Niehaus, Kaltschmidt, Christian, Noll, Thomas, Kaltschmidt, Barbara, M. Lienhard Schmitz, Janine Müller, Klenke Christin, Müller, Janine, Darius Widera, Kaltschmidt Barbara, Widera, Darius, Engelen Thomas, Niehaus Karsten, Schmitz, M., Schmitz, M Lienhard, Widera, Darius ; https://orcid.org/, Niehaus, Karsten, Widera Darius, Noll, Thomas ; https://orcid.org/, Thomas Engelen, Müller Janine, Barbara Kaltschmidt, Noll Thomas, Schmitz M. Lienhard, Engelen, Thomas, M Lienhard Schmitz   +30 more
core   +2 more sources

Yangonin Blocks Tumor Necrosis Factor-α–Induced Nuclear Factor-κB–Dependent Transcription by Inhibiting the Transactivation Potential of the RelA/p65 Subunit

Journal of Pharmacological Sciences, 2012
The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and apoptosis. In our search for NF-κB inhibitors from natural resources, we identified yangonin from Piper methysticum as an ...
Juan Ma, He Liang, Hong Ri Jin, Nguyen Tien Dat, Shan Yu Zhang, Ying Zi Jiang, Ji Xing Nan, Donghao Li, Xue Wu, Jung Joon Lee, Xuejun Jin   +10 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Water Solution of Onion Crude Powder Inhibits Rankl-Induced Osteoclastogenesis through Erk, P38 and Nf-Kappab Pathways [PDF]

, 2009
Summary Onion powder has been reported to decrease the ovariectomy-induced bone resorption of rats. However, the molecular mechanism of onion powder on the bone cells has not been reported.
湯智昕;符文美;楊榮森, TANG, CHIH-HSIN;FU, WEN-MEI;YANG, RONG-SEN   +1 more
core  

Effect of pepsin in p-NF-κB nuclear localization, in human hypopharyngeal keratinocytes (HHK) and human hypopharyngeal primary cells (HHPC). [PDF]

, 2016
Immunofluorescence (IF) staining of phospho-NF-κB (p-p65 S529) is demonstrated in (A) HHK and (B) HHPC treated by 0.1 mg/ml pepsin at different pH (acid, pH 4.0; weakly acidic, pH 5.0 and neutral, pH 7.0) and corresponding controls. Acidic-pepsin treated
Julia Toman (3545372), Dimitra Vageli (3545375), Clarence T. Sasaki (3545369)   +2 more
core   +1 more source

NF-κB Activation Exacerbates, but Is not Required for Murine Bmpr2-Related Pulmonary Hypertension

Diseases, 2014
Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation.
Megha Talati, Haitham Mutlak, Kirk B. Lane, Wei Han, Anna Hemnes, Outi Mutlak, Tom Blackwell, Rinat Zaynagetdinov, Timothy S. Blackwell, James West   +9 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source