Results 121 to 130 of about 525,635 (287)
NF-κB regulates gTlr9 alternative splicing. [PDF]
, 2016 Two inhibitors BAY and SR, which targeted either NF-κB or AP-1 transcription factors, respectively, were applied under CpG ODN stimulation. The inhibition of one transcription factor under stimulation would result in activation of the other (see text for
Tien-Hsien Chang (112560) +3 more
core +1 more source
APOBEC3C‐Mediated NF‐κB Activation Promotes Malignant Progression of Gliomas
Immunity, Inflammation and DiseaseObjective To analyze the clinicopathological features, immunological characteristics, and prognostic value of APOBEC3C in gliomas, and to verify the specific mechanism by which it mediates the malignant progression of gliomas.
Chao Zhang +6 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand +5 more
wiley +1 more source
NF-κB regulates neuronal ankyrin-G via a negative feedback loop. [PDF]
, 2017 The axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with the cytoskeletal anchor protein ankyrin-G in immunoprecipitation and proximity-ligation ...
Jochen Prehn (7895672) +6 more
core +3 more sources
Arthritis Care &Research, EarlyView.Objective This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements. Methods This multicenter cohort included 938 patients who were newly diagnosed with PsA between 2013 and 2023.
Batoul Hojeij +11 more
wiley +1 more source
Biochemical and functional analysis of the ubiquitin binding properties of the NF-κB regulator NEMO [PDF]
, 2013 Many types of ubiquitin chains can modify several proteins at the activated TNFR. Additionally many UBD-containing ubiquitin receptors localise there to mediate the signal constituted by these chains.
Kensche, Tobias
core
Expression of Ig receptors on the U937-NF-κB reporter cell line. [PDF]
, 2016 U937 cells express FcγRI, FcγRII, FcαRI of Fc receptors (A). Transfection with NF-κB-GFP did not alter the Fc receptor expression patterns in the U937 cell line (B).
László Homolya (538824) +8 more
core +1 more source
Cancer Biology & Medicine, 2017 The role of the transcription factor NF-κB in shaping the cancer microenvironment is becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF-κB function, and causes extensive changes in genomic chromatin that ultimately ...
Spiros A. Vlahopoulos
doaj +1 more source
PLOS ONE, 2015 We recently reported that the human immunodeficiency virus type-1 (HIV-1) Tat protein induced the expression of programmed death ligand-1 (PD-L1) on dendritic cells (DCs) through a TLR4 pathway. However, the underlying mechanisms by which HIV-1 Tat protein induces the abnormal hyper-activation of the immune system seen in HIV-1 infected patients remain
Ben Haij, Nawal +8 more
openaire +7 more sources
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source