Results 121 to 130 of about 599,978 (240)
Advanced Science, EarlyView.Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang +8 more
wiley +1 more source
1,8-cineol inhibits nuclear translocation of NF-κB p65 and NF-κB-dependent transcriptional activity.
, 2013 Greiner J, Müller J, Zeuner M, et al. 1,8-cineol inhibits nuclear translocation of NF-κB p65 and NF-κB-dependent transcriptional activity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research .
Thorsten Seidel +28 more
core +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
NMI negatively regulates the activation of NF-κB/p65 [PDF]
, 2017 NF-κB是细胞内重要的转录因子之一，其调控细胞内大量基因的表达，这些基因参与机体重要的生理过程，如细胞存活和增殖、细胞凋亡、细胞应激应答、炎症反应和免疫应答。许多刺激都可以活化NF-κB信号通路，大部分刺激引起NF-κB的活化均汇集到IKK复合体。IKK复合体磷酸化IκBα，导致IκBα被泛素化并最终通过26S蛋白酶体降解。IκBα的降解会导致NF-κB二聚体的释放，自由的NF-κB二聚体进入细胞核，在细胞核中经过一系列翻译后修饰，NF ...
赵稼宝
core
C. jejuni induces NF-κB signaling in IL-10−/−; NF-κBEGFP mice.
, 2013 (A) C. jejuni induces NF-κB activity in the colon of IL-10−/−; NF-κBEGFP mice. IL-10wt/wt; NF-κBEGFP and IL-10−/−; NF-κBEGFP mice were colonized for 14 days with C.
Hans H. Herfarth (369890) +6 more
core +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source
NF-κB/miR-21/PTEN pathway modulated cell viability.
, 2015 (A) mRNA expressions of NF-κB, miR-21 and PTEN in the cells transduced with Lenti-control, Lenti-NF-κB and Lenti-shNF-κB. The miR-21 level was significantly increased while the PTEN was decreased in the cells transduced with Lenti-NF-κB compared with ...
Zhenhua Yang (150675) +5 more
core +1 more source
Advanced Science, EarlyView.Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn +20 more
wiley +1 more source
Engineering Microbial Particles for Next‐Generation Biomedical Platforms
Advanced Science, EarlyView.Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li +7 more
wiley +1 more source