Results 141 to 150 of about 525,635 (287)
, 2016 As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability.
D'Ignazio, Laura +3 more
core +1 more source
Review: NF-κB pathways in the pathogenesis of Multiple Sclerosis and the therapeutic implications
Frontiers in Molecular Neuroscience, 2016 Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling pathways are involved in cell immune responses, apoptosis and infections.
Saskia Michaela Leibowitz, Jun Yan
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano +11 more
wiley +1 more source
NF-κB activation by rFliC. [PDF]
, 2018 (A) HEK-BlueTM-hTLR5 cells (1.4 x 105cells/ml) in HEK-Blue™ Detection medium were incubated with 1, 10, and 100 ng/ml rFliC in three independent experiments. The cells stimulated with flagellin purified from S.
Pongsak Utaisincharoen (5394845) +8 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan +7 more
wiley +1 more source
Development of a secreted cell-permeable NF-κB inhibitor to control inflammation [PDF]
, 2010 PhDRheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease, of unknown aetiology. Several disease-modulating approaches have been developed in the past years, however these are expensive, usually accompanied by unwanted side-effects ...
Koutsokeras, Apostolos
core
NF-κB signaling in inflammation [PDF]
, 2017 The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses.
Ting Liu +3 more
core +1 more source
Advanced Healthcare Materials, EarlyView.What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu +13 more
wiley +1 more source
NF-κB is a central regulator of hypoxia-induced gene expression
EMBO ReportsHypoxia is both a physiological and pathological signal in cells. Changes in gene expression play a critical role in the cellular response to hypoxia, enabling cells to adapt to reduced oxygen availability. These changes are primarily mediated by the HIF
Dilem Shakir +5 more
doaj +1 more source
Real-Time Monitoring of Nuclear Factor κB Activity in Cultured Cells and in Animal Models
Molecular Imaging, 2009 Nuclear factor κB (NF-κB) is a transcription factor that plays a major role in many human disorders, including immune diseases and cancer. We designed a reporter system based on NF-κB responsive promoter elements driving expression of the secreted ...
Christian E. Badr +5 more
doaj +1 more source