Results 131 to 140 of about 577,005 (273)
Advanced Healthcare Materials, EarlyView.Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave +8 more
wiley +1 more source
Journal of Translational Medicine, 2012 Background Most DNA-damaging chemotherapeutic agents activate the transcription factor nuclear factor κB (NF-κB). However, NF-κB activation can either protect from or contribute to the growth suppressive effects of the agent.
Caporali Simona +8 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Using pixel‐aware digital light processing, the authors created high‐resolution, dissolvable microneedles from a PEGDA/VP matrix. These microneedles encapsulate curcumin and 5‐fluorouracil and dissolve in the skin, co‐delivering drugs directly to tumours.
Rutuja N. Meshram, Dimitrios A. Lamprou
wiley +1 more source
Review: NF-κB pathways in the pathogenesis of Multiple Sclerosis and the therapeutic implications
Frontiers in Molecular Neuroscience, 2016 Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling pathways are involved in cell immune responses, apoptosis and infections.
Saskia Michaela Leibowitz, Jun Yan
doaj +1 more source
Biochemical and functional analysis of the ubiquitin binding properties of the NF-κB regulator NEMO [PDF]
, 2013 Many types of ubiquitin chains can modify several proteins at the activated TNFR. Additionally many UBD-containing ubiquitin receptors localise there to mediate the signal constituted by these chains.
Kensche, Tobias
core
Advanced Healthcare Materials, EarlyView.Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu +10 more
wiley +1 more source
Cellular Specificity of NF-κB Function in the Nervous System
Frontiers in Immunology, 2019 Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key functions in a wide array of biological systems. While the role of NF-κB in processes, such as host immunity and oncogenesis has been more clearly defined, an ...
Erica C. Dresselhaus, Mollie K. Meffert
doaj +1 more source
NF-κB expression in peribronchovascular areas and bronchiolar epithelial cells.
, 2019 The numbers of NF-κB+ cells in peribronchovascular areas (A) and the NF-κB gene expression levels in bronchiolar epithelial cells (B) obtained for the Control groups after 1 (n = 10 and 5, respectively), 3 (n = 6 and 5, respectively), and 6 (n = 7 and 4,
Rildo Aparecido Volpini (602014) +14 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Magnetically responsive nanoparticles enable remote control over biomaterials, cells, and engineered tissues. This review summarizes material design, biological safety, fabrication and actuation strategies, computational validation, and translational pathways that support the development of magnetic tissue‐engineering platforms and future magnetically ...
Konstantinos Ioannidis +8 more
wiley +1 more source
Pathogenetics mechanisms in celiac disease [PDF]
, 2006 La tesi di Dottorato, svolta presso il Dipartimento di Farmacologia Sperimentale, redatta in lingua inglese ed intitolata “PATHOGENETICS MECHANISMS IN CELIAC DISEASE” ha riguardato lo studio dei meccanismi molecolari coinvolti nella patogenesi della ...
De Stefano, Daniela
core +1 more source