Results 41 to 50 of about 525,635 (287)

Fatty Acid Metabolism Provides an Essential Survival Signal in OxPhos and BCR DLBCL Cells

Biomedicines
Backgroung/objectives: Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of malignant lymphoma and is a heterogeneous disease with various gene and chromosomal abnormalities.
Aurélie Montagne, Konstantina Kotta, Karoline Kielbassa-Elkadi, Isabelle Martins, José Ángel Martinez-Climent, Guido Kroemer, Catherine Thieblemont, Véronique Baud   +7 more
doaj   +1 more source

Kombinasi Artemisinin dan Ekstrak Moringa oleifera Menurunkan Ekspresi NF-κB namun Tidak Menurunkan Ekspresi iNOS pada Otak Mencit Diinfeksi Malaria

Jurnal Kedokteran Brawijaya, 2015
Malaria otak merupakan manifestasi tersering dari infeksi malaria berat yang ditandai dengan respon inflamasi berlebih di otak. Untuk mencegah terjadinya resistensi, penggunaan obat antimalaria standar (artemisinin) harus dikombinasikan dengan obat antimalaria lain.
Herpan Syafii Harahap, Mochammad Dalhar, Tinny Endang Endang H, Eviana Norahmawati, Loeki Enggar Fitri   +4 more
openaire   +2 more sources

An unexpected twist to the activation of IKKβ:TAK1 primes IKKβ for activation by autophosphorylation [PDF]

, 2014
IKKß {IkB [inhibitor of NF-?B (nuclear factor ?B)] kinase ß} is required to activate the transcription factor NF-?B, but how IKKß itself is activated in vivo is still unclear.
Lawrence, T., Peggie, M. W., Lawrence, Toby, Peggie, Mark W., Clark, Kristopher, Cohen, P., Cohen, Philip; id_orcid, Clark, K., Zhang, Jiazhen, Zhang, J.   +9 more
core   +1 more source

Nuclear Factor-κB/p65 (Rel A) Is Constitutively Activated in Human Prostate Adenocarcinoma and Correlates with Disease Progression

Neoplasia: An International Journal for Oncology Research, 2004
Aberrant nuclear factor-κB (NF-κB) activation has been implicated in the pathogenesis of several human malignancies. In this study, we determined whether NF-κB is constitutively activated in human prostate adenocarcinoma, and, if so, whether increased NF-
Sanjeev Shukla, Gregory T. MacLennan, Pingfu Fu, Jigar Patel, Susan R. Marengo, Martin l. Resnick, Sanjay Gupta   +6 more
doaj   +1 more source

Plant polyphenols as inhibitors of NF-κB induced cytokine production—a potential anti-inflammatory treatment for Alzheimer's disease? [PDF]

Frontiers in Molecular Neuroscience, 2015
Alzheimer’s disease (AD) is a neurodegenerative disorder that impacts the daily lives of many sufferers throughmemory loss as well as behavioral and cognitive changes. AD is themost common form of dementia. One in ten people over the age of 65, and around half of those over 85 have AD.
Karunaweera, Niloo (S31677), Raju, Ritesh (R17740), Gyengesi, Erika (R17270), Muench, Gerald (R12224)   +3 more
openaire   +3 more sources

Modulation of granulocyte-endothelium interactions by antileukoproteinase : inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium [PDF]

, 2006
Antileukoproteinase (ALP) is a physiological inhibitor of granulocytic serine proteases that has been shown to have anti-inflammatory properties in addition to its antiproteolytic activity.
Rikard Holmdahl, Kutty Nandakumar, Vollmar, Brigitte,, Sehnert, Bettina,, Harald Burkhardt, Rupert Hallmann, Hallmann, Rupert,, Anja Kühl, Reinhard Voll, Ibrahim, Saleh, Nandakumar, Kutty Selva,, Holmdahl, Rikard, Voll, Reinhard,, Burkhardt, Harald,, Gierer, Philip,, Bettina Sehnert, Burkhardt, Harald, Hallmann, Rupert, Saleh Ibrahim, Nandakumar, Kutty Selva, Vollmar, Brigitte, Ibrahim, Saleh,, Kühl, Anja,, Kuehl, Anja, Sehnert, Bettina, Philip Gierer, Gierer, Philip, Kühl, Anja, Lund University., Voll, Reinhard, Holmdahl, Rikard,, Brigitte Vollmar   +31 more
core   +1 more source

The Ubiquitination of NF-κB Subunits in the Control of Transcription

Cells, 2016
Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors fundamental in the control of the inflammatory response. The transcription of hundreds of genes involved in inflammation and immune homeostasis require NF-κB ...
Patricia E. Collins, Izaskun Mitxitorena, Ruaidhrí J. Carmody   +2 more
doaj   +1 more source

Ginkgetin inhibits proliferation of HeLa cells via activation of p38/NF-κB pathway

Cellular and Molecular Biology, 2019
Effect of ginkgetin on proliferation of human cervical cancer (HeLa) cells and the underlying mechanism   were investigated. Human cervical cancer (HeLa) cells were cultured at 37 °C in 10 % fetal bovine serum (FBS) supplemented RPMI 1640 medium in a humidified incubator containing 5 % CO2.
Jianxia, Cheng, Yun, Li, Jianping, Kong
openaire   +3 more sources

NF-κB translocation of select anti-inflammatory extracts. [PDF]

, 2018
A: Fluorescence microscopy images of NF-κB stained HeLa-TLR4 dual reporter cells incubated with extracts or vehicle (70% ethanol), followed by stimulation with LPS-EB.
Jan Neumann (2071201), Anna Lena Leifke (5848115), Janine Fröhlich-Nowoisky (817174), Eckhard Thines (220610), Ulrich Pöschl (359201), Detlef Schuppan (204756), Anne Schink (5848112), Kurt Lucas (3909487), Christoph Cremer (91), Bettina Weber (508855), Kira Ziegler (3909481)   +10 more
core   +1 more source

Transcription factor NF-κB is modulated by symbiotic status in a sea anemone model of cnidarian bleaching

Scientific Reports, 2017
Transcription factor NF-κB plays a central role in immunity from fruit flies to humans, and NF-κB activity is altered in many human diseases. To investigate a role for NF-κB in immunity and disease on a broader evolutionary scale we have characterized NF-
Katelyn M. Mansfield, Nicole M. Carter, Linda Nguyen, Phillip A. Cleves, Anar Alshanbayeva, Leah M. Williams, Camerron Crowder, Ashley R. Penvose, John R. Finnerty, Virginia M. Weis, Trevor W. Siggers, Thomas D. Gilmore   +11 more
doaj   +1 more source