Results 11 to 20 of about 525,635 (287)
NF-kappa B activation correlates with disease phenotype in Crohn's disease. [PDF]
PLoS ONE, 2017 Unregulated activation of nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of Crohn's disease. In this study, we investigated the clinical characteristics and disease outcome of Crohn's disease patients with varying levels of the NF-κB
Yoo Min Han +8 more
doaj +1 more source
NF-κB signaling regulates myelination in the CNS [PDF]
Frontiers in Molecular Neuroscience, 2014 Besides myelination of neuronal axons by oligodendrocytes to facilitate propagation of action potentials, oligodendrocytes also support axon survival and function. A key transcription factor involved in these processes is nuclear factor-κB (NF-κB), a hetero or homodimer of the Rel family of proteins, including p65, c-Rel, RelB, p50, and p52.
Thomas eBlank +2 more
openaire +3 more sources
TLR7, TLR9, MyD88, and NF-κB role on platelet aggregation in Yucatecan patients with type 2 diabetes
Alad, 2022 Objective: To analyze the expression of TLR7, TLR9, and signaling proteins MyD88 and NF-κB, and their relationship with platelet aggregation in Yucatecan patients with type 2 diabetes. Material and methods: Platelet aggregation was determined by light transmission and protein expression by flow cytometry in 31 patients and 29 controls from Yucatan ...
LucÃa G. González-Espinosa +7 more
openaire +2 more sources
NF-κB affects E-box-mediated transcription. [PDF]
, 2021 Steady-state luciferase reporter assay in transiently transfected 293T cells. (A) NF-κB itself, in the absence of BMAL1/CLOCK (B/C), did not activate the E-box transcription from the 3xE-box::Luc or Per2-dLuc reporters (left, middle), but repressed BMAL1/
Yang Shen (66591) +11 more
core +1 more source
Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions
Cells, 2016 The family of NF-κB transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development.
Véronique Baud, Davi Collares
doaj +1 more source
NF-κB and Human Cancer: What Have We Learned over the Past 35 Years?
Biomedicines, 2021 Transcription factor NF-κB has been extensively studied for its varied roles in cancer development since its initial characterization as a potent retroviral oncogene. It is now clear that NF-κB also plays a major role in a large variety of human cancers,
Thomas D. Gilmore
doaj +1 more source
NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity [PDF]
, 2021 International audienceConventional type 1 dendritic cells (cDC1s) are critical for antitumor immunity. They acquire antigens from dying tumor cells and cross-present them to CD8 + T cells, promoting the expansion of tumor-specific cytotoxic T cells ...
Manh, Thien +16 more
core +1 more source
Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation [PDF]
Frontiers in Genetics, 2014 Cardiovascular diseases such as atherosclerosis are one of the leading causes of morbidity and mortality worldwide. The clinical manifestations of atherosclerosis, which include heart attack and stroke, occur several decades after initiation of the disease and become more severe with age.
Cheng, Henry S. +4 more
openaire +3 more sources
Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study. [PDF]
, 2010 INTRODUCTION: Streptococcus pneumoniae remains a major global health problem and a leading cause of death in children worldwide. The factors that influence development of pneumococcal sepsis remain poorly understood, although increasing evidence points ...
Rautanen, Anna +51 more
core +1 more source
Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma [PDF]
, 2021 Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes that mediate various cellular activities, including propagation, differentiation, motility, and survival.
Albadrani, Ghadeer M +23 more
core +1 more source