Results 31 to 40 of about 104,328 (314)
Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]
, 2011 The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli +15 more
core +1 more source
eLife, 2020 NLRP3 inflammasome activation and complement-mediated inflammation have been implicated in promoting choroidal neovascularization (CNV) in age-related macular degeneration (AMD), but central questions regarding their contributions to AMD pathogenesis remain unanswered.
Jakob Malsy +4 more
openaire +3 more sources
ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination [PDF]
The EMBO Journal, 2019 Deubiquitination of NLRP3 has been suggested to contribute to inflammasome activation, but the roles and molecular mechanisms are still unclear. We here demonstrate that ABRO1, a subunit of the BRISC deubiquitinase complex, is necessary for optimal NLRP3-ASC complex formation, ASC oligomerization, caspase-1 activation, and IL-1β and IL-18 production ...
Guangming Ren +16 more
openaire +2 more sources
Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1
Drug Design, Development and Therapy, 2022 Kai Jiang,1,2 Jing Feng,2 Xia Qi,2 Lili Ran,2 Lixin Xie2 1Department of Ophthalmology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China; 2Eye Institute of Shandong First Medical University, Eye Hospital
Jiang K, Feng J, Qi X, Ran L, Xie L
doaj
NLRP3 Inflammasome and Inflammatory Diseases [PDF]
Oxidative Medicine and Cellular Longevity, 2020 Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation.
Zheng Wang +8 more
openaire +2 more sources
Journal of Inflammation Research, 2023 XiaoJin Sun,1,* Yang Deng,2,* PengXin Ge,3,* Qiang Peng,4 Ismatullah Soufiany,4 Lin Zhu,4 Rui Duan4 1Faculty of Pharmacy, Bengbu Medical College, Anhui Engineering Technology Research Center of Biochemical Pharmaceuticals, Bengbu, Anhui ...
Sun X +6 more
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Spotlight on the NLRP3 inflammasome pathway
, 2018 Marine Groslambert,1–5 Bénédicte F Py1–5 1Centre International de Recherche en Infectiologie (CIRI), Université de Lyon, Lyon, France; 2INSERM, U1111, Lyon, France; 3Ecole Normale Supérieure de Lyon, Lyon, France ...
Py BF, Groslambert M
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Frontiers in Bioscience-LandmarkSubarachnoid hemorrhage (SAH), a severe cerebrovascular disorder, is principally instigated by the rupture of an aneurysm. Early brain injury (EBI), which gives rise to neuronal demise, microcirculation impairments, disruption of the blood-brain barrier,
Xi Zhang +6 more
doaj +1 more source
Pathological Mechanism and Targeted Drugs of COPD
International Journal of COPD, 2022 Peng Guo,1 Rui Li,2 Tie Hua Piao,3 Chun Lan Wang,3 Xiao Lu Wu,3 Hong Yan Cai3 1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Changchun, 130000, People’s Republic of China; 2Graduate School, Beijing ...
Guo P +5 more
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ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages [PDF]
The Journal of Immunology, 2017 Abstract The nucleotide-binding oligomerization domain–like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a molecular platform that induces caspase-1 activation and subsequent IL-1β maturation, and is implicated in inflammatory diseases; however, little is known about the negative regulation of NLRP3 inflammasome ...
Akira Kawashima +12 more
openaire +2 more sources