The EMBO Journal, 2023 AbstractThe NLRP3 inflammasome plays a key role in responding to pathogens, and endogenous damage and mitochondria are intensively involved in inflammasome activation. The NLRP3 inflammasome forms multiprotein complexes and its sequential assembly is important for its activation.
Yeon‐Ji Park +11 more
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Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]
, 2015 Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky +6 more
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Journal of Inflammation Research, 2021 Zhi-He Liu,1 Lin Zhang,2 Fan-Jing Jing,1 Shu-Xin Xiao,1 Yan Gao,1 Hai-Yan Bian,1 Xia Zhao1 1Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People’s Republic of China; 2Laboratory of Molecular Diagnosis
Liu ZH +6 more
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Klotho controls the brain-immune system interface in the choroid plexus. [PDF]
, 2018 Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn +7 more
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ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
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ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages [PDF]
The Journal of Immunology, 2017 Abstract The nucleotide-binding oligomerization domain–like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a molecular platform that induces caspase-1 activation and subsequent IL-1β maturation, and is implicated in inflammatory diseases; however, little is known about the negative regulation of NLRP3 inflammasome ...
Akira Kawashima +12 more
openaire +2 more sources
Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1
Drug Design, Development and Therapy, 2022 Kai Jiang,1,2 Jing Feng,2 Xia Qi,2 Lili Ran,2 Lixin Xie2 1Department of Ophthalmology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China; 2Eye Institute of Shandong First Medical University, Eye Hospital
Jiang K, Feng J, Qi X, Ran L, Xie L
doaj
A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis [PDF]
, 2019 Background: Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin ...
Barbierato, M. +5 more
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Treatment of Ulcerative Colitis by Cationic Liposome Delivered NLRP3 siRNA
International Journal of Nanomedicine, 2023 Jing Huang,1,* Mengmeng Dai,1,* Mingxia He,1,* Weicheng Bu,1 Liwen Cao,1 Jing Jing,1 Run Cao,1 Hailong Zhang,1 Ke Men2 1Joint National Laboratory for Antibody Drug Engineering, The First Affiliated Hospital, Henan University, Kaifeng, Henan ...
Huang J +8 more
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Functional deficits precede structural lesions in mice with high-fat diet-induced diabetic retinopathy [PDF]
, 2016 Obesity predisposes to human type 2 diabetes, the most common cause of diabetic retinopathy. To determine if high-fat diet–induced diabetes in mice can model retinal disease, we weaned mice to chow or a high-fat diet and tested the hypothesis that diet ...
Bligard, Gregory W +5 more
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