Results 31 to 40 of about 113,850 (298)

The Inflammasome: A Promising Potential Therapeutic Target for Early Brain Injury Following Subarachnoid Hemorrhage

Frontiers in Bioscience-Landmark
Subarachnoid hemorrhage (SAH), a severe cerebrovascular disorder, is principally instigated by the rupture of an aneurysm. Early brain injury (EBI), which gives rise to neuronal demise, microcirculation impairments, disruption of the blood-brain barrier,
Xi Zhang, Chao Xu, Zi-Yuan Liu, Dong-Yuan Zhang, Bo-Hong Wang, Jing Wang, Xin-Min Ding   +6 more
doaj   +1 more source

Pathological Mechanism and Targeted Drugs of COPD

International Journal of COPD, 2022
Peng Guo,1 Rui Li,2 Tie Hua Piao,3 Chun Lan Wang,3 Xiao Lu Wu,3 Hong Yan Cai3 1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Changchun, 130000, People’s Republic of China; 2Graduate School, Beijing ...
Guo P, Li R, Piao TH, Wang CL, Wu XL, Cai HY   +5 more
doaj  

Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype

Journal of Inflammation Research, 2022
Jesús Beltrán-García,1– 3 Rebeca Osca-Verdegal,1,3 Daniel Pérez-Cremades,2,3 Susana Novella,2,3 Carlos Hermenegildo,2,3 Federico V Pallardó,1– 3 José Luis García-Giménez1– 3 1Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER ...
Beltrán-García J, Osca-Verdegal R, Pérez-Cremades D, Novella S, Hermenegildo C, Pallardó FV, García-Giménez JL   +6 more
doaj  

Cardiolipin and the Nlrp3 Inflammasome [PDF]

Cell Metabolism, 2013
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting ...
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway

Drug Design, Development and Therapy, 2020
Cancan Huang, Chaotao Zhang, Panpan Yang, Rui Chao, Ziqi Yue, Congshan Li, Jie Guo, Minqi Li Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue ...
Huang C, Zhang C, Yang P, Chao R, Yue Z, Li C, Guo J, Li M   +7 more
doaj  

Mangiferin Mitigates Lipopolysaccharide-Induced Lung Injury by Inhibiting NLRP3 Inflammasome Activation

Journal of Inflammation Research, 2021
Ning Li,* Rui Xiong,* Ruyuan He, Bohao Liu, Bo Wang, Qing Geng Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Wang ...
Li N, Xiong R, He R, Liu B, Wang B, Geng Q   +5 more
doaj  

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Journal of Inflammation Research, 2021
Abdullah Al Mamun,1 Yanqing Wu,2 Fatema Nasrin,3,4 Afroza Akter,5 Masuma Afrin Taniya,6 Fahad Munir,7 Chang Jia,8 Jian Xiao1 1Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital and School of Pharmaceutical Sciences ...
Al Mamun A, Wu Y, Nasrin F, Akter A, Taniya MA, Munir F, Jia C, Xiao J   +7 more
doaj  

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source