Results 21 to 30 of about 120,852 (299)

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation [PDF]

, 2012
Because of their outstanding physical properties, carbon nanotubes (CNTs) are promising new materials in the field of nanotechnology. It is therefore imperative to assess their adverse effects on human health.
Dardenne, Christophe, Meunier, Etienne, Bernard Pipy, David Olagnier, José Bernad, Agnès Coste, Authier, Hélène, Emmanuel Flahaut, Béraud, Maryse, Bernad, José, Flahaut, Emmanuel, Etienne Meunier, Maryse Béraud, Pipy, Bernard, Lise Lefèvre, Christophe Dardenne, Coste, Agnès, Hélène Authier, Olagnier, David, Lefèvre, Lise   +19 more
core   +1 more source

Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]

, 2011
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli, Khader Valli Rupanagudi, Allam, R., Anders Hans-Joachim, Darisipudi, M.N., Ramanjaneyulu Allam, Allam Ramanjaneyulu, Murthy Narayana Darisipudi, Hans-Joachim Anders, Rupanagudi, K.V., Rupanagudi, Khader Valli, Anders, Hans-Joachim, Anders, H.J., Darisipudi, Murthy Narayana, Darisipudi Murthy Narayana, Allam, Ramanjaneyulu   +15 more
core   +2 more sources

MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation

The EMBO Journal, 2023
Abstract The NLRP3 inflammasome plays a key role in responding to pathogens, and endogenous damage and mitochondria are intensively involved in inflammasome activation. The NLRP3 inflammasome forms multiprotein complexes and its sequential assembly is important for its activation.
Yeon‐Ji Park, Niranjan Dodantenna, Yonghyeon Kim, Tae‐Hwan Kim, Ho‐Soo Lee, Young‐Suk Yoo, June Heo, Jae‐Ho Lee, Myung‐Hee Kwon, Ho Chul Kang, Jong‐Soo Lee, Hyeseong Cho   +11 more
openaire   +2 more sources

ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages [PDF]

The Journal of Immunology, 2017
Abstract The nucleotide-binding oligomerization domain–like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a molecular platform that induces caspase-1 activation and subsequent IL-1β maturation, and is implicated in inflammatory diseases; however, little is known about the negative regulation of NLRP3 inflammasome ...
Akira Kawashima, Tadayoshi Karasawa, Kenji Tago, Hiroaki Kimura, Ryo Kamata, Fumitake Usui-Kawanishi, Sachiko Watanabe, Satoshi Ohta, Megumi Funakoshi-Tago, Ken Yanagisawa, Tadashi Kasahara, Koichi Suzuki, Masafumi Takahashi   +12 more
openaire   +3 more sources

The role of the NLRP3 inflammasome in gout [PDF]

, 2011
Sarah R Kingsbury1,2, Philip G Conaghan1,2, Michael F McDermott1,21Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine 2NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds,
Conaghan, P, Sarah R Kingsbury, Kingsbury, SR, Michael F McDermott, Philip G Conaghan, McDermott, M   +5 more
core   +1 more source

Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1

Drug Design, Development and Therapy, 2022
Kai Jiang,1,2 Jing Feng,2 Xia Qi,2 Lili Ran,2 Lixin Xie2 1Department of Ophthalmology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China; 2Eye Institute of Shandong First Medical University, Eye Hospital
Jiang K, Feng J, Qi X, Ran L, Xie L
doaj  

Knocking In the NLRP3 Inflammasome [PDF]

Immunity, 2009
Mutations in the human NLRP3 gene cause interleukin-1beta-related autoinflammatory syndromes. In this issue of Immunity, Brydges et al. (2009) and Meng et al. (2009) report the characterization of Nlrp3 gene-targeted mice harboring mutations mimicking those causing disease in humans.
openaire   +2 more sources

Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome

Nature Immunology, 2022
Caspase-11 detection of intracellular lipopolysaccharide (LPS) from invasive Gram-negative bacteria mediates noncanonical activation of the NLRP3 inflammasome. While avirulent bacteria do not invade the cytosol, their presence in tissues necessitates clearance and immune system mobilization.
Julien Moretti, Baosen Jia, Zachary Hutchins, Soumit Roy, Hilary Yip, Jiahui Wu, Meimei Shan, Samie R. Jaffrey, Jörn Coers, J. Magarian Blander   +9 more
openaire   +2 more sources

Diminazene Ameliorates Neuroinflammation by Suppression of Astrocytic miRNA-224-5p/NLRP3 Axis in Alzheimer’s Disease Model

Journal of Inflammation Research, 2023
XiaoJin Sun,1,* Yang Deng,2,* PengXin Ge,3,* Qiang Peng,4 Ismatullah Soufiany,4 Lin Zhu,4 Rui Duan4 1Faculty of Pharmacy, Bengbu Medical College, Anhui Engineering Technology Research Center of Biochemical Pharmaceuticals, Bengbu, Anhui ...
Sun X, Deng Y, Ge P, Peng Q, Soufiany I, Zhu L, Duan R   +6 more
doaj  

Lyssavirus Matrix Protein Inhibits NLRP3 Inflammasome Assembly by Binding to NLRP3

Cell Reports, 2023
Lyssavirus is a kind of neurotropic pathogen that needs to evade peripheral host immunity to enter the central nervous system to accomplish infection. NLRP3 inflammasome activation is essential for the host to defend against pathogen invasion. This study demonstrates that the matrix protein (M) of lyssavirus can inhibit both the priming step and the ...
Baokun Sui, Jianqing Zhao, Jinxiao Wang, Jiaxin Zheng, Rui Zhou, Di Wu, Zonghui Zeng, Yueming Yuan, Zhenfang Fu, Ling Zhao, Ming Zhou   +10 more
openaire   +3 more sources