Results 21 to 30 of about 113,850 (298)

Knocking In the NLRP3 Inflammasome [PDF]

Immunity, 2009
Mutations in the human NLRP3 gene cause interleukin-1beta-related autoinflammatory syndromes. In this issue of Immunity, Brydges et al. (2009) and Meng et al. (2009) report the characterization of Nlrp3 gene-targeted mice harboring mutations mimicking those causing disease in humans.
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Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome

Nature Immunology, 2022
Caspase-11 detection of intracellular lipopolysaccharide (LPS) from invasive Gram-negative bacteria mediates noncanonical activation of the NLRP3 inflammasome. While avirulent bacteria do not invade the cytosol, their presence in tissues necessitates clearance and immune system mobilization.
Julien Moretti, Baosen Jia, Zachary Hutchins, Soumit Roy, Hilary Yip, Jiahui Wu, Meimei Shan, Samie R. Jaffrey, Jörn Coers, J. Magarian Blander   +9 more
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NLRP3 and CARD8 polymorphisms influence higher disease activity in rheumatoid arthritis [PDF]

Journal of Medical Biochemistry, 2016
Background: The activation of NLRP3-inflammasome may contribute to inflammatory processes in rheumatoid arthritis (RA). Functional polymorphisms in the genes coding for its components NLRP3 and CARD8 were associated with a proinflammatory phenotype.
Jenko Barbara, Praprotnik Sonja, Tomšić Matija, Dolžan Vita   +3 more
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Serum Pentaxin 3 (PTX3) Promotes NLRP3 Inflammasome and Pyroptosis in Patients with Up-Regulated Myasthenia Gravis

Frontiers in Bioscience-Landmark, 2023
Background: Myasthenia gravis (MG) is an autoantibodies-mediated autoimmune disease with the complications of neuromuscular junction transmission. In this study, we aimed to investigate the molecular regulatory roles of pentaxin 3 (PTX3) in patients and ...
Yao Li, Shuhui Wang, Yunpeng Liu, Yongbo Zhang   +3 more
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Genetic Polymorphisms in NLRP3 Inflammasome-Associated Genes in Patients with B-Cell Non-Hodgkin’s Lymphoma

Journal of Inflammation Research, 2021
Zhi-He Liu,1 Lin Zhang,2 Fan-Jing Jing,1 Shu-Xin Xiao,1 Yan Gao,1 Hai-Yan Bian,1 Xia Zhao1 1Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, People’s Republic of China; 2Laboratory of Molecular Diagnosis
Liu ZH, Zhang L, Jing FJ, Xiao SX, Gao Y, Bian HY, Zhao X   +6 more
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Antiviral Activity of Oridonin Against Herpes Simplex Virus Type 1

Drug Design, Development and Therapy, 2022
Kai Jiang,1,2 Jing Feng,2 Xia Qi,2 Lili Ran,2 Lixin Xie2 1Department of Ophthalmology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, People’s Republic of China; 2Eye Institute of Shandong First Medical University, Eye Hospital
Jiang K, Feng J, Qi X, Ran L, Xie L
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The role of the NLRP3 inflammasome in gout [PDF]

, 2011
Sarah R Kingsbury1,2, Philip G Conaghan1,2, Michael F McDermott1,21Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine 2NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds,
Conaghan, P, Sarah R Kingsbury, Kingsbury, SR, Michael F McDermott, Philip G Conaghan, McDermott, M   +5 more
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Lyssavirus Matrix Protein Inhibits NLRP3 Inflammasome Assembly by Binding to NLRP3

Cell Reports, 2023
Lyssavirus is a kind of neurotropic pathogen that needs to evade peripheral host immunity to enter the central nervous system to accomplish infection. NLRP3 inflammasome activation is essential for the host to defend against pathogen invasion. This study demonstrates that the matrix protein (M) of lyssavirus can inhibit both the priming step and the ...
Baokun Sui, Jianqing Zhao, Jinxiao Wang, Jiaxin Zheng, Rui Zhou, Di Wu, Zonghui Zeng, Yueming Yuan, Zhenfang Fu, Ling Zhao, Ming Zhou   +10 more
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Diminazene Ameliorates Neuroinflammation by Suppression of Astrocytic miRNA-224-5p/NLRP3 Axis in Alzheimer’s Disease Model

Journal of Inflammation Research, 2023
XiaoJin Sun,1,* Yang Deng,2,* PengXin Ge,3,* Qiang Peng,4 Ismatullah Soufiany,4 Lin Zhu,4 Rui Duan4 1Faculty of Pharmacy, Bengbu Medical College, Anhui Engineering Technology Research Center of Biochemical Pharmaceuticals, Bengbu, Anhui ...
Sun X, Deng Y, Ge P, Peng Q, Soufiany I, Zhu L, Duan R   +6 more
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Spotlight on the NLRP3 inflammasome pathway

, 2018
Marine Groslambert,1–5 Bénédicte F Py1–5 1Centre International de Recherche en Infectiologie (CIRI), Université de Lyon, Lyon, France; 2INSERM, U1111, Lyon, France; 3Ecole Normale Supérieure de Lyon, Lyon, France ...
Py BF, Groslambert M
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