Results 1 to 10 of about 782,437 (306)

Detecting Respiratory Pathogens for Diagnosing Lower Respiratory Tract Infections at the Point of Care: Challenges and Opportunities

Biosensors
Lower respiratory tract infections (LRTIs) are a leading cause of mortality worldwide, claiming millions of lives each year and imposing significant healthcare costs.
Francisco M. Bouzada, Bartomeu Mestre, Andreu Vaquer, Sofía Tejada, Roberto de la Rica   +4 more
doaj   +1 more source

Bioreactance reliably detects preload responsiveness by the end-expiratory occlusion test when averaging and refresh times are shortened

Annals of Intensive Care, 2021
Background The end-expiratory occlusion (EEXPO) test detects preload responsiveness, but it is 15 s long and induces small changes in cardiac index (CI).
Francesco Gavelli, Alexandra Beurton, Jean-Louis Teboul, Nello De Vita, Danila Azzolina, Rui Shi, Arthur Pavot, Xavier Monnet   +7 more
doaj   +1 more source

Impact of interventions to reduce nosocomial transmission of SARS-CoV-2 in English NHS Trusts: a computational modelling study

BMC Infectious Diseases
Background Prior to September 2021, 55,000–90,000 hospital inpatients in England were identified as having a potentially nosocomial SARS-CoV-2 infection. This includes cases that were likely missed due to pauci- or asymptomatic infection.
Stephanie Evans, James Stimson, Diane Pople, Peter J White, Mark H Wilcox, Julie V Robotham   +5 more
doaj   +1 more source

Aging-caused the changes of the gut microbiota drive intestinal barrier dysfunction and increase sepsis susceptibility

Gut Microbes
Physiological and pathological changes associated with aging contribute to deteriorating disease prognosis in sepsis. However, the mechanisms by which these disturbances exacerbate inflammation remain underexplored.
Huoyan Liang, Xianfei Ding, Shaohua Liu, Shuai Tong, Xu Wang, Zihao Zhang, Wei Wang, Xiaojuan Zhang, Yangyang Yuan, Yong Jiang, Tongwen Sun   +10 more
doaj   +1 more source

Innate immune training in the neonatal response to sepsis

Molecular Medicine
Neonates, especially those born prematurely, are highly vulnerable to infection-induced mortality. Numerous observational and immunological studies in newborns have shown that live attenuated vaccines have beneficial, non-specific effects (NSEs) against ...
Jaimar C. Rincon, Dayuan Wang, Valerie E. Polcz, Evan L. Barrios, Marvin L. Dirain, Ricardo F. Ungaro, Dina C. Nacionales, Leilani Zeumer-Spataro, Feifei Xiao, Philip A. Efron, Lyle L. Moldawer, Guoshuai Cai, Shawn D. Larson   +12 more
doaj   +1 more source

The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure

Annals of Intensive Care, 2017
Background Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could benefit the most from this treatment.
Ignacio Martin-Loeches, Arturo Muriel-Bombín, Ricard Ferrer, Antonio Artigas, Jordi Sole-Violan, Leonardo Lorente, David Andaluz-Ojeda, Adriele Prina-Mello, Ruben Herrán-Monge, Borja Suberviola, Ana Rodriguez-Fernandez, Pedro Merino, Ana M. Loza, Pablo Garcia-Olivares, Eduardo Anton, Eduardo Tamayo, Wysali Trapiello, Jesús Blanco, Jesús F. Bermejo-Martin, the GRECIA group   +19 more
doaj   +1 more source

Efficacy of mesenchymal stem cell therapy for sepsis: a meta-analysis of preclinical studies

Stem Cell Research & Therapy, 2020
Background Multiple studies have reported that mesenchymal stem cell (MSC) therapy has beneficial effects in experimental models of sepsis. However, this finding remains inconclusive.
Xue-Yi Sun, Xian-Fei Ding, Huo-Yan Liang, Xiao-Juan Zhang, Shao-Hua Liu, Bing-Han, Xiao-Guang Duan, Tong-Wen Sun   +7 more
doaj   +1 more source

Differential Interaction of Platelet-Derived Extracellular Vesicles With Circulating Immune Cells: Roles of TAM Receptors, CD11b, and Phosphatidylserine

Frontiers in Immunology, 2018
Secretion and exchange of biomolecules by extracellular vesicles (EVs) are crucial in intercellular communication and enable cells to adapt to alterations in their microenvironment.
Birgit Fendl, Tanja Eichhorn, René Weiss, Carla Tripisciano, Andreas Spittler, Michael B. Fischer, Viktoria Weber   +6 more
doaj   +1 more source

Revolution in sepsis: a symptoms-based to a systems-based approach?

Journal of Biomedical Science
Severe infection and sepsis are medical emergencies. High morbidity and mortality are linked to CNS dysfunction, excessive inflammation, immune compromise, coagulopathy and multiple organ dysfunction.
Geoffrey P. Dobson, Hayley L. Letson, Jodie L. Morris   +2 more
doaj   +1 more source

Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach

BMC Bioinformatics, 2019
Background Reactivation of the telomerase reverse transcriptase gene TERT is a central feature for unlimited proliferation of the majority of cancers. However, the underlying regulatory processes are only partly understood. Results We assembled regulator
Alexandra M. Poos, Theresa Kordaß, Amol Kolte, Volker Ast, Marcus Oswald, Karsten Rippe, Rainer König   +6 more
doaj   +1 more source