Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis [PDF]
, 1994 Die Diskussion am Ende des Artikels wurde gelöscht (§137l UrhG).Background The proteolytic enzyme elastase released by granulocytes (polymorphonuclear leukocytes [PMN]) in high concentrations during sepsis causes degradation of essential plasma proteins,
Ertel, Wolfgang +6 more
core +1 more source
Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care [PDF]
, 2013 Although many sepsis biomarkers have shown promise in selected patient groups, only C-reactive protein and procalcitonin (PCT) have entered clinical practice.
Berger, Mario +10 more
core +2 more sources
Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study
Scientific Reports, 2022 Observational studies have indicated an association between iron status and risk of sepsis and COVID-19. We estimated the effect of genetically-predicted iron biomarkers on risk of sepsis and risk of being hospitalized with COVID-19, performing a two ...
Randi Marie Mohus +8 more
doaj +1 more source
Takotsubo cardiomyopathy and sepsis: a systematic review [PDF]
, 2017 Takotsubo cardiomyopathy (TTC) is characterized by a systolic dysfunction localized in the apical and medial aspect of the left ventricle. It is usually related to physical or emotional stress.
Agarwal V +15 more
core +1 more source
Circulating levels of micronutrients and risk of infections: a Mendelian randomization study
BMC Medicine, 2023 Background Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections.
Helene M. Flatby +4 more
doaj +1 more source
Antimicrobial Resistance in England 2017 to 2021 (ESPAUR Report 2021–22)
Medical Sciences Forum, 2023 The English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) antimicrobial resistance (AMR) chapter reports on bacterial, viral, and fungal AMR trends between 2017 and 2021 in England.
Rebecca Guy +9 more
doaj +1 more source
Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis [PDF]
, 2019 BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Biologically active adrenomedullin (bio-ADM) is an emerging biomarker for sepsis.
Bergmann, A. +4 more
core +1 more source
Identifying which septic patients have increased mortality risk using severity scores:a cohort study [PDF]
, 2014 Background: Early aggressive therapy can reduce the mortality associated with severe sepsis but this relies on prompt recognition, which is hindered by variation among published severity criteria. Our aim was to test the performance of different severity
Davey, Peter G +5 more
core +4 more sources
Sphingolipidomics in Translational Sepsis Research–Biomedical Considerations and Perspectives
Frontiers in Medicine, 2021 Scientific Background: Sphingolipids are a highly diverse group of lipids with respect to physicochemical properties controlling either structure, distribution, or function, all of them regulating cellular response in health and disease.
Ralf A. Claus +3 more
doaj +1 more source
, 2013 Purpose of review: This review discusses the current developments in biomarkers for sepsis. Recent findings: With quantum leaps in technology, an array of biomarkers will become available within the next decade as point-of-care tools that will likely ...
Singer, M
core +1 more source