Results 31 to 40 of about 536,044 (309)

All that seems sepsis is not sepsis

Indian Journal of Critical Care Medicine, 2013
Catastrophic antiphospholipid antibody syndrome (CAPS) resembles severe sepsis in its acute presentation, with features of systemic inflammatory response syndrome (SIRS) leading to multiple organ dysfunction. Infections are the best known triggers of CAPS. This emphasizes the need for early diagnosis and aggressive treatment as the mortality is as high
Guleria, Vivek S., Chauhan, Prabhat, Shankar, Subramanian, Nair, Velu   +3 more
openaire   +3 more sources

Glucocorticoids in Sepsis: To Be or Not to Be

Frontiers in Immunology, 2020
Sepsis is a highly lethal syndrome resulting from dysregulated immune and metabolic responses to infection, thereby compromising host homeostasis. Activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequently adrenocortical glucocorticoid (GC) production during sepsis are important regulatory processes to maintain homeostasis.
Jolien Vandewalle, Jolien Vandewalle, Claude Libert, Claude Libert   +3 more
openaire   +4 more sources

Sphingolipidomics in Translational Sepsis Research–Biomedical Considerations and Perspectives

Frontiers in Medicine, 2021
Scientific Background: Sphingolipids are a highly diverse group of lipids with respect to physicochemical properties controlling either structure, distribution, or function, all of them regulating cellular response in health and disease.
Ralf A. Claus, Markus H. Graeler, Markus H. Graeler, Markus H. Graeler   +3 more
doaj   +1 more source

Digital PCR applications for the diagnosis and management of infection in critical care medicine

Critical Care, 2022
Infection (either community acquired or nosocomial) is a major cause of morbidity and mortality in critical care medicine. Sepsis is present in up to 30% of all ICU patients.
Irene Merino, Amanda de la Fuente, Marta Domínguez-Gil, José María Eiros, Ana P. Tedim, Jesús F. Bermejo-Martín   +5 more
doaj   +1 more source

Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis [PDF]

, 1994
Die Diskussion am Ende des Artikels wurde gelöscht (§137l UrhG).Background The proteolytic enzyme elastase released by granulocytes (polymorphonuclear leukocytes [PMN]) in high concentrations during sepsis causes degradation of essential plasma proteins,
Schildberg, Friedrich-Wilhelm, Wolfgang Ertel, Jochum, Marianne, Thiele, Volker, Jarrar, Doreid, Kenney, John, Faist, Eugen, Ertel, Wolfgang   +7 more
core   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Time-to-positivity of blood cultures in children with sepsis [PDF]

, 2018
Background: Blood cultures are essential for the diagnosis and further appropriate treatment in children with suspected sepsis. In most hospitals, children will be empirically treated or closely monitored for at least 48 h awaiting results of blood ...
Thomas Riedel, Heininger, Ulrich, Kahlert, Christian R., Stocker, M., Dierig, Alexa, Posfay Barbe, Klara, Hasters, P., Aebi, Christoph, Eric Giannoni, Hasters, Paul, Christoph Berger, Schlapbach, Luregn J, Riedel, T., Posfay-Barbe, Klara M, Philipp K. A. Agyeman, Giannoni, E., Niederer-Loher, A., Luregn J. Schlapbach, Posfay-Barbe, K.M., Christoph Aebi, Berger, Christoph, Paul Hasters, Agyeman, Philipp, Bernhard-Stirnemann, Sara, Stocker, Martin, Kahlert, C.R., Donas, Alex, Alexa Dierig, null null, Schlapbach, Luregn Jan, Martin Stocker, Anita Niederer-Loher, Riedel, Thomas, Donas, A., Klara M. Posfay-Barbe, Niederer-Loher, Anita, Schlapbach, L.J., Agyeman, PKA, Sara Bernhard-Stirnemann, Posfay-Barbe, Klara M., Berger, C., Heininger, U., Aebi, C., Relly, Christa, Agyeman, Philipp K A, Berger, Christoph; https://orcid.org/, Christian R. Kahlert, Bernhard-Stirnemann, S., Alex Donas, Swiss Pediatric Sepsis Study, Relly, C., Dierig, A., Agyeman, Philipp K. A., Kahlert, Christian R, Schlapbach, Luregn J., Christa Relly, Giannoni, Eric, Ulrich Heininger   +57 more
core   +1 more source

mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health – a prospective observational cohort study protocol

BMJ Open, 2022
Introduction Maternal sepsis remains a leading cause of death in pregnancy. Physiological adaptations to pregnancy obscure early signs of sepsis and can result in delays in recognition and treatment.
Daniel White, Sarah Bell, Shaun Oram, Robert Andrews, Mallinath Chakraborty, Sarah Edkins, W John Watkins, Patrícia R S Rodrigues, Angela Strang, Summia Zaher, Simran Sharma, Luke C Davies, Linda Moet, James E McLaren, Valerie B O’Donnell, Peter Ghazal, Edward Parkinson, Nicos Angelopoulos, Freya Shepherd, Kate Megan Megan Davies, Kate Siddall, Vikki Keeping, Kathryn Simpson, Federica Faggian, Maryanne Bray, Claire Bertorelli, Rachel E Collis, Mario Labeta   +27 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Association between sepsis incidence and regional socioeconomic deprivation and health care capacity in Germany – an ecological study

BMC Public Health, 2021
Background Sepsis is a substantial health care burden. Data on regional variation in sepsis incidence in Germany and any possible associations with regional socioeconomic deprivation and health care capacity is lacking.
Norman Rose, Claudia Matthäus-Krämer, Daniel Schwarzkopf, André Scherag, Sebastian Born, Konrad Reinhart, Carolin Fleischmann-Struzek   +6 more
doaj   +1 more source