Results 11 to 20 of about 583,528 (304)

Towards a novel carbon device for the treatment of sepsis [PDF]

, 2004
Sepsis is a systemic inflammatory response to infection in which the balance of pro- andanti-inflammatory mediators, which normally isolate and eliminate infection, is disrupted.
Phillips, G.J., Courtney, J.M., Kozynchenko, O.P., Barnes, L.M., Lloyd, A.W., Melillo, M., Murphy, M.C., Sandeman, S.R., Tennison, S.R., Howell, C.A., Gaylor, J.D.S., Davies, J.G., Mikhalovsky, S.V.   +12 more
core   +4 more sources

The Endothelium in Sepsis [PDF]

Shock, 2016
Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the key factor in the progression from sepsis to organ failure. Endothelial functions affected by sepsis include vasoregulation, barrier function, inflammation, and hemostasis.
Ince, Can, Mayeux, Philip R., Nguyen, Trung, Gómez, Hernando, Kellum, John A., Ospina Tascón Gustavo A., Hernández P., Glenn, Murray, Patrick, De Backer, Daniel   +8 more
openaire   +7 more sources

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis [PDF]

, 2014
Sepsis is characterized by overlapping phases of excessive inflammation temporally aligned with an immunosuppressed state, defining a complex clinical scenario that explains the lack of successful therapeutic options.
Thiemermann, C, McArthur, S, le Faouder, P, Coldewey, S.M., Thiemermann, C., Coldewey, SM, Perretti, M, Gobbetti, T., Perretti, M., Gobbetti, T, Cenac, N, Chen, J, Chen, J., McArthur, S., le Faouder, P., Flower, RJ, Cenac, N., Flower, R.J.   +17 more
core   +1 more source

Composed endotypes to guide antibiotic discontinuation in sepsis

Critical Care, 2019
Overuse of empiric antibiotic therapy in the ICU is responsible for promoting the dissemination of multidrug-resistant (MDR) bacteria. Shortened antibiotic treatment duration could contribute to palliating the emergence of MDR.
Jesus F. Bermejo-Martin, David Andaluz-Ojeda, Marta Martin-Fernandez, Cesar Aldecoa, Raquel Almansa   +4 more
doaj   +1 more source

Female-Specific Association of Plasma N-Terminal Pro-Brain Natriuretic Peptide With Organ Dysfunction and Prognosis in Sepsis: A Retrospective Study

Critical Care Explorations, 2021
Objectives:. The plasma level of N-terminal pro-brain natriuretic peptide is regulated by sex hormones. It has been controversial whether N-terminal pro-brain natriuretic peptide is a prognosis marker for sepsis.
Shuangyi Yin, PhD, Yijie Zhang, MD, Yu Guo, MD, Qing Bai, MD, Zhibo Lu, MD, Na Chen, MD, Edmund J. Miller, PhD, Wei Li, MD, PhD   +7 more
doaj   +1 more source

Sepsis [PDF]

The Lancet, 2020
Cube, Maja von, Schumacher, Martin, Timsit, Jéan-François   +2 more
  +15 more sources

Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial) [PDF]

, 2012
Introduction: Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim of this study was to determine if the acute administration of atorvastatin reduces sepsis progression in ...
Matthew W Cooke, Patel, Jaimin M, Thickett, David R, David R Thickett, Alan Jones, Anthony H Barnett, Hawkey, P. M., Jaimin M Patel, Catherine Snaith, Perkins, Gavin D., Smith, F. Gao, Jones, Alan, Gao Smith, Fang; id_orcid, Fang Gao, Linhartova, Lucie, Snaith, Catherine, Hong, Tan, Gao, Fang, Tan Hong, Lucie Linhartova, Hawkey, Peter, Peter Hawkey, Cooke, Matthew W, Thickett, David R; id_orcid, Barnett, Anthony H, Cooke, Matthew, Barnett, A. H., Gavin D Perkins, Melody, Teresa, Perkins, Gavin D, Patel, Jaimin M., Thickett, David R., Teresa Melody   +32 more
core   +1 more source

Epigenetics of Sepsis

Critical Care Medicine, 2020
Objectives: Recent evidence from the fields of microbiology and immunology, as well as a small number of human sepsis studies, suggest that epigenetic regulation may play a central role in the pathogenesis of sepsis. The term “epigenetics” refers to regulatory mechanisms that control gene expression but are not related to ...
Binnie, Alexandra, Tsang, Jennifer L. Y., Hu, Pingzhao, Carrasqueiro, Gabriela, Castelo-Branco, Pedro, dos Santos, Claudia C.   +5 more
openaire   +3 more sources

Cell-free DNA and outcome in sepsis. [PDF]

, 2012
Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition
Rhodes, A, Cecconi, M
core   +1 more source

Glucocorticoids in Sepsis: To Be or Not to Be

Frontiers in Immunology, 2020
Sepsis is a highly lethal syndrome resulting from dysregulated immune and metabolic responses to infection, thereby compromising host homeostasis. Activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequently adrenocortical glucocorticoid (GC) production during sepsis are important regulatory processes to maintain homeostasis.
Jolien Vandewalle, Jolien Vandewalle, Claude Libert, Claude Libert   +3 more
openaire   +4 more sources