Results 11 to 20 of about 536,044 (309)

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis [PDF]

, 2014
Sepsis is characterized by overlapping phases of excessive inflammation temporally aligned with an immunosuppressed state, defining a complex clinical scenario that explains the lack of successful therapeutic options.
Thiemermann, C, McArthur, S, le Faouder, P, Coldewey, S.M., Thiemermann, C., Coldewey, SM, Perretti, M, Gobbetti, T., Perretti, M., Gobbetti, T, Cenac, N, Chen, J, Chen, J., McArthur, S., le Faouder, P., Flower, RJ, Cenac, N., Flower, R.J.   +17 more
core   +1 more source

Sesamin attenuates intestinal injury in sepsis via the HMGB1/TLR4/IL-33 signalling pathway

Pharmaceutical Biology, 2020
Context Sepsis is currently one of the leading causes of death in intensive care units (ICUs). Sesamin was previously reported to inhibit inflammation. However, no studies have revealed the impact of sesamin on sepsis.
Zhi-Ling Li, Min Gao, Ming-Shi Yang, Xue-Fei Xiao, Jing-Jing Liu, Bing-Chang Yang   +5 more
doaj   +1 more source

Antimicrobial Resistance: Professional and Public Education, Engagement, and Training Activities 2021–2022 (ESPAUR Report)

Medical Sciences Forum, 2023
This is a summary of initiatives to engage and educate the general public and healthcare professionals about antimicrobial use, stewardship and resistance, as covered in the 2021–2022 English Surveillance Programme for Antimicrobial Utilisation and ...
Catherine V. Hayes, Jordan Charlesworth, Diane Ashiru-Oredope, Eirwen Sides, Amy Jackson, Emily Cooper, Brieze Read, Donna Seaton, Lorna Flintham, Harpreet Sidhu, Donna M. Lecky   +10 more
doaj   +1 more source

Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial) [PDF]

, 2012
Introduction: Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim of this study was to determine if the acute administration of atorvastatin reduces sepsis progression in ...
Matthew W Cooke, Patel, Jaimin M, Thickett, David R, David R Thickett, Alan Jones, Anthony H Barnett, Hawkey, P. M., Jaimin M Patel, Catherine Snaith, Perkins, Gavin D., Smith, F. Gao, Jones, Alan, Gao Smith, Fang; id_orcid, Fang Gao, Linhartova, Lucie, Snaith, Catherine, Hong, Tan, Gao, Fang, Tan Hong, Lucie Linhartova, Hawkey, Peter, Peter Hawkey, Cooke, Matthew W, Thickett, David R; id_orcid, Barnett, Anthony H, Cooke, Matthew, Barnett, A. H., Gavin D Perkins, Melody, Teresa, Perkins, Gavin D, Patel, Jaimin M., Thickett, David R., Teresa Melody   +32 more
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Cell-free DNA and outcome in sepsis. [PDF]

, 2012
Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition
Rhodes, A, Cecconi, M
core   +1 more source

Composed endotypes to guide antibiotic discontinuation in sepsis

Critical Care, 2019
Overuse of empiric antibiotic therapy in the ICU is responsible for promoting the dissemination of multidrug-resistant (MDR) bacteria. Shortened antibiotic treatment duration could contribute to palliating the emergence of MDR.
Jesus F. Bermejo-Martin, David Andaluz-Ojeda, Marta Martin-Fernandez, Cesar Aldecoa, Raquel Almansa   +4 more
doaj   +1 more source

Female-Specific Association of Plasma N-Terminal Pro-Brain Natriuretic Peptide With Organ Dysfunction and Prognosis in Sepsis: A Retrospective Study

Critical Care Explorations, 2021
Objectives:. The plasma level of N-terminal pro-brain natriuretic peptide is regulated by sex hormones. It has been controversial whether N-terminal pro-brain natriuretic peptide is a prognosis marker for sepsis.
Shuangyi Yin, PhD, Yijie Zhang, MD, Yu Guo, MD, Qing Bai, MD, Zhibo Lu, MD, Na Chen, MD, Edmund J. Miller, PhD, Wei Li, MD, PhD   +7 more
doaj   +1 more source

Delayed wound repair in sepsis is associated with reduced local pro-inflammatory cytokine expression [PDF]

, 2013
Sepsis is one of the main causes for morbidity and mortality in hospitalized patients. Moreover, sepsis associated complications involving impaired wound healing are common.
Marzi, Ingo, Anna Lena Sander, Heike Jakob, Dirk Henrich, Michael Albig, Roxane Weber, Sommer, Katharina, Weber, Roxane, Jakob, Heike, Sander, Anna Lena, Henrich, Dirk, Ingo Marzi, Albig, Michael, Katharina Sommer, Frank, Johannes, Johannes Frank   +15 more
core   +1 more source

Epigenetics of Sepsis

Critical Care Medicine, 2020
Objectives: Recent evidence from the fields of microbiology and immunology, as well as a small number of human sepsis studies, suggest that epigenetic regulation may play a central role in the pathogenesis of sepsis. The term “epigenetics” refers to regulatory mechanisms that control gene expression but are not related to ...
Binnie, Alexandra, Tsang, Jennifer L. Y., Hu, Pingzhao, Carrasqueiro, Gabriela, Castelo-Branco, Pedro, dos Santos, Claudia C.   +5 more
openaire   +3 more sources

Common Variants of TLR1 Associate with Organ Dysfunction and Sustained Pro- Inflammatory Responses during Sepsis [PDF]

, 2010
Background: Toll-like receptors (TLRs) are critical components for host pathogen recognition and variants in genes participating in this response influence susceptibility to infections.
Pino Yanes, Maria, Antoni Torres, Zavala Elizabeth, Villar, Jesús, Jesús Villar, Ferrer Miguel, Jesús Blanco, Pino-Yanes Maria, Espinosa Elena, García Bello, Miguel, Miguel García-Bello, Milena Casula, Ferrer Monreal, Miquel, Torres Antoni, Muriel, Arturo, Arturo Muriel, Flores Carlos, Flores, Carlos, Carlos Flores, Blanco Jesús, Torres Martí, Antoni, Villar Jesús, Almudena Corrales, Elizabeth Zavala, Blanco, Jesús, García-Bello Miguel, Miguel Ferrer, Elena Espinosa, Maria Pino-Yanes, Espinosa, Elena, Casula Milena, null null, Zavala Zegarra, Elizabeth, Muriel Arturo, Casula, Milena, GRECIA and GEN-SEP Groups, Corrales Almudena, Corrales, Almudena, GEN-SEP groups   +38 more
core   +1 more source