Results 1 to 10 of about 5,642,725 (257)

Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical trial

Critical Care, 2023
Objective To evaluate the safety, feasibility, and efficacy of combined adrenergic blockade with propranolol and clonidine in patients with severe traumatic brain injury (TBI).
Mina F. Nordness, Amelia W. Maiga, Laura D. Wilson, Tatsuki Koyama, Erika L. Rivera, Shayan Rakhit, Michael de Riesthal, Cari L. Motuzas, Madison R. Cook, Deepak K. Gupta, James C. Jackson, Shawniqua Williams Roberson, William J. Meurer, Roger J. Lewis, Geoffrey T. Manley, Pratik P. Pandharipande, Mayur B. Patel   +16 more
doaj   +1 more source

Heterogeneity in design and analysis of ICU delirium randomized trials: a systematic review

Trials, 2021
Background There is a growing number of randomized controlled trials (RCTs) evaluating interventions to prevent or treat delirium in the intensive care unit (ICU).
Elizabeth Colantuoni, Mounica Koneru, Narjes Akhlaghi, Ximin Li, Mohamed D. Hashem, Victor D. Dinglas, Karin J. Neufeld, Michael O. Harhay, Dale M. Needham   +8 more
doaj   +1 more source

Instruments Assessing Cognitive Impairment in Survivors of Critical Illness and Reporting of Race Norms: A Systematic Review

Critical Care Explorations, 2022
OBJECTIVE:. To conduct a systematic review to summarize cognitive instruments being used in long-term outcome studies of survivors of adult critical illness, as well as evaluate whether these measures are reported as using patient demographic norms ...
Rameela Raman, PhD, Spencer J. DesAutels, MLIS, Alana M. Lauck, MS, Alexa M. Scher, BA, Rachel L. Walden, MLIS, Amy L. Kiehl, MA, Erin M. Collar, MPH, E. Wesley Ely, MD, MPH, Pratik P. Pandharipande, MD, MSCI, James C. Jackson, PsyD   +9 more
doaj   +1 more source

Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice

Critical Care, 2017
Background Despite many animal studies and clinical trials, mortality in sepsis remains high. This may be due to the fact that most experimental studies of sepsis employ young animals, whereas the majority of septic patients are elderly (60 − 70 years ...
Karel Tyml, Scott Swarbreck, Cynthia Pape, Dan Secor, James Koropatnick, Qingping Feng, Ruud A. W. Veldhuizen, Sean E. Gill   +7 more
doaj   +1 more source

Antimicrobial exposure and the risk of delirium in critically ill patients

Critical Care, 2018
Background Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimicrobials have differential ...
Jessica J. Grahl, Joanna L. Stollings, Shayan Rakhit, Anna K. Person, Li Wang, Jennifer L. Thompson, Pratik P. Pandharipande, E. Wesley Ely, Mayur B. Patel   +8 more
doaj   +1 more source

Influence of Limonin on Malignant Biological Behavior of Non-small Cell Lung Cancer Cells by Regulating JAK2/STAT3 Signaling Pathway

Zhongliu Fangzhi Yanjiu, 2023
Objective To investigate the influence of limonin on the malignant biological behavior of non-small cell lung cancer (NSCLC) cells by regulating the protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling ...
HU Huijie, ZHENG Xiaolu, LEI Lifeng
doaj   +1 more source

COVID-19: ICU delirium management during SARS-CoV-2 pandemic

Critical Care, 2020
The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19), emerged as a public health threat in December 2019 and was declared a pandemic by the World Health Organization in March 2020.
Katarzyna Kotfis, Shawniqua Williams Roberson, Jo Ellen Wilson, Wojciech Dabrowski, Brenda T. Pun, E. Wesley Ely   +5 more
doaj   +1 more source

Effectiveness of Convalescent Plasma Therapy in Treating COVID-19: an Evidence-based Case Report

Acta Medica Indonesiana, 2022
Background: Convalescent plasma is a potentially beneficial, tolerable, and available additional treatment option for COVID-19. This study aims to evaluate whether the administration of convalescent plasma therapy leads to improved clinical outcomes in ...
Mira Yulianti, Christian Johan, Gurmeet Singh, Eric Daniel Tenda, Herikurniawan Herikurniawan, I Putu Eka Krisnha Wijaya   +5 more
doaj   +2 more sources

Inhibition of Murine Pulmonary Microvascular Endothelial Cell Apoptosis Promotes Recovery of Barrier Function under Septic Conditions

Mediators of Inflammation, 2017
Sepsis is characterized by injury of the pulmonary microvasculature and the pulmonary microvascular endothelial cells (PMVEC), leading to barrier dysfunction and acute respiratory distress syndrome (ARDS).
Lefeng Wang, Sanjay Mehta, Michael Brock, Sean E. Gill   +3 more
doaj   +1 more source

A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage

Pathophysiology, 2021
A full understanding of the molecular mechanisms implicated in the etiopathogenesis of juvenile idiopathic arthritis (JIA) is lacking. A critical role for leukocyte proteolytic activity (e.g., elastase and cathepsin G) has been proposed.
Eric K. Patterson, Nicolas Vanin Moreno, Douglas D. Fraser, Gediminas Cepinskas, Takaya Iida, Roberta A. Berard   +5 more
doaj   +1 more source