Nonthyroidal illness in critically ill children [PDF]
Current Opinion in Endocrinology, Diabetes & Obesity, 2019 Purpose of review This review summarizes recent literature on nonthyroidal illness syndrome (NTI) and outcome of pediatric critical illness, to provide insight in pathophysiology and therapeutic implications. Recent findings NTI is typically characterized by lowered triiodothyronine
Jacobs, An +2 more
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The impact of known breast cancer polygenes on critical illness insurance [PDF]
, 2015 Genetic studies indicate that the inherited risk of breast cancer is mediated by the well-studied major genes BRCA1 and BRCA2, and a polygenic component, probably with many genes each making a small contribution. Recently, seven polygenes have been found
Adams, Craig +2 more
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Mediators of Inflammation, 2017 Sepsis is characterized by injury of the pulmonary microvasculature and the pulmonary microvascular endothelial cells (PMVEC), leading to barrier dysfunction and acute respiratory distress syndrome (ARDS).
Lefeng Wang +3 more
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Managing clinical uncertainty: an ethnographic study of the impact of critical care outreach on end‐of‐life transitions in ward‐based critically ill patients with a life‐limiting illness [PDF]
, 2018 © 2018 Crown copyright. Journal of Clinical Nursing © 2018 John Wiley & Sons LtdRapid response teams, such as critical care outreach teams, have prominent roles in managing end-of-life transitions in critical illness, often questioning appropriateness of
Mclellan, Jude +4 more
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A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage
Pathophysiology, 2021 A full understanding of the molecular mechanisms implicated in the etiopathogenesis of juvenile idiopathic arthritis (JIA) is lacking. A critical role for leukocyte proteolytic activity (e.g., elastase and cathepsin G) has been proposed.
Eric K. Patterson +5 more
doaj +1 more source
Psychopolitics: Peter Sedgwick’s legacy for mental health movements [PDF]
, 2009 This paper re-considers the relevance of Peter Sedgwick's Psychopolitics (1982) for a politics of mental health. Psychopolitics offered an indictment of ‘anti-psychiatry’ the failure of which, Sedgwick argued, lay in its deconstruction of the category of
A Bell +74 more
core +1 more source
The Intestinal Microbiome after Traumatic Injury
Microorganisms, 2023 The intestinal microbiome plays a critical role in host immune function and homeostasis. Patients suffering from—as well as models representing—multiple traumatic injuries, isolated organ system trauma, and various severities of traumatic injury have ...
Jennifer A. Munley +6 more
doaj +1 more source
Role of the microbiome, probiotics, and 'dysbiosis therapy' in critical illness. [PDF]
, 2016 Purpose of reviewLoss of 'health-promoting' microbes and overgrowth of pathogenic bacteria (dysbiosis) in ICU is believed to contribute to nosocomial infections, sepsis, and organ failure (multiple organ dysfunction syndrome).
Knight, Rob +2 more
core +2 more sources
Expert Consensus on the Application of Ulinastatin in Common Clinical Critical Illness [PDF]
Zhongguo quanke yixue, 2023 Ulinastatin is mainly applied in the treatment of acute pancreatitis, but also in other common clinical critical illnesses such as shock, sepsis, evere pneumonia, cute respiratory distress syndrome, several acute poisoning, severe heat stroke, severe ...
Expert group of expert consensus on the application of ulinastatin in common clinical critical illness
doaj +1 more source
Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness. [PDF]
, 2014 UnlabelledWe analyzed the 16S rRNA amplicon composition in fecal samples of selected patients during their prolonged stay in an intensive care unit (ICU) and observed the emergence of ultra-low-diversity communities (1 to 4 bacterial taxa) in 30% of the ...
Alverdy, John C +10 more
core +3 more sources