Results 11 to 20 of about 543,603 (266)
Mediators of Inflammation, 2017 Sepsis is characterized by injury of the pulmonary microvasculature and the pulmonary microvascular endothelial cells (PMVEC), leading to barrier dysfunction and acute respiratory distress syndrome (ARDS).
Lefeng Wang +3 more
doaj +1 more source
A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage
Pathophysiology, 2021 A full understanding of the molecular mechanisms implicated in the etiopathogenesis of juvenile idiopathic arthritis (JIA) is lacking. A critical role for leukocyte proteolytic activity (e.g., elastase and cathepsin G) has been proposed.
Eric K. Patterson +5 more
doaj +1 more source
The Intestinal Microbiome after Traumatic Injury
Microorganisms, 2023 The intestinal microbiome plays a critical role in host immune function and homeostasis. Patients suffering from—as well as models representing—multiple traumatic injuries, isolated organ system trauma, and various severities of traumatic injury have ...
Jennifer A. Munley +6 more
doaj +1 more source
The microbiome and critical illness [PDF]
The Lancet Respiratory Medicine, 2016 The central role of the microbiome in critical illness is supported by a half century of experimental and clinical study. The physiological effects of critical illness and the clinical interventions of intensive care substantially alter the microbiome.
openaire +2 more sources
Trials, 2021 Background The impact of specialist palliative care intervention in patients undergoing surgery for cancer has not been studied extensively. The SCOPE randomized controlled trial will investigate the effect of specialist palliative care intervention in ...
Onur M. Orun +7 more
doaj +1 more source
Critical Care, 2023 Background Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may lead to targeted interventions.
Jeremy A. Balch +8 more
doaj +1 more source
Participant retention practices in longitudinal clinical research studies with high retention rates
BMC Medical Research Methodology, 2017 Background There is a need for improving cohort retention in longitudinal studies. Our objective was to identify cohort retention strategies and implementation approaches used in studies with high retention rates.
Martha Abshire +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro +11 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta +6 more
wiley +1 more source
COVID-19 Associated Pulmonary Aspergillosis: A Case Series
Acta Medica Indonesiana, 2022 Coronavirus disease 2019 (COVID-19) has been a worldwide pandemic with several problems, one of which is the lack of definitive treatment. COVID-19-associated pulmonary aspergillosis (CAPA), the presence of invasive pulmonary aspergillosis (IPA) in COVID-
Mira Yulianti +5 more
doaj +2 more sources