Results 11 to 20 of about 547,079 (266)
Mediators of Inflammation, 2017 Sepsis is characterized by injury of the pulmonary microvasculature and the pulmonary microvascular endothelial cells (PMVEC), leading to barrier dysfunction and acute respiratory distress syndrome (ARDS).
Lefeng Wang +3 more
doaj +1 more source
Immunomodulation in the critically ill [PDF]
British Journal of Anaesthesia, 2009 Immunotherapy in the critically ill is an appealing notion because of the apparent abnormal immune and inflammatory responses seen in so many patients. The administration of a medication that could alter immune responses and decrease mortality in patients with sepsis could represent a 'magic bullet'.
Webster, N.R., Galley, H.F.
openaire +2 more sources
A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage
Pathophysiology, 2021 A full understanding of the molecular mechanisms implicated in the etiopathogenesis of juvenile idiopathic arthritis (JIA) is lacking. A critical role for leukocyte proteolytic activity (e.g., elastase and cathepsin G) has been proposed.
Eric K. Patterson +5 more
doaj +1 more source
The Intestinal Microbiome after Traumatic Injury
Microorganisms, 2023 The intestinal microbiome plays a critical role in host immune function and homeostasis. Patients suffering from—as well as models representing—multiple traumatic injuries, isolated organ system trauma, and various severities of traumatic injury have ...
Jennifer A. Munley +6 more
doaj +1 more source
The microbiome and critical illness [PDF]
The Lancet Respiratory Medicine, 2016 The central role of the microbiome in critical illness is supported by a half century of experimental and clinical study. The physiological effects of critical illness and the clinical interventions of intensive care substantially alter the microbiome.
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Trials, 2021 Background The impact of specialist palliative care intervention in patients undergoing surgery for cancer has not been studied extensively. The SCOPE randomized controlled trial will investigate the effect of specialist palliative care intervention in ...
Onur M. Orun +7 more
doaj +1 more source
Chronic Critical Illness [PDF]
American Journal of Respiratory and Critical Care Medicine, 2010 Abstract Although advances in intensive care have enabled more patients to survive an acute critical illness, they also have created a large and growing population of chronically critically ill patients with prolonged dependence on mechanical ventilation and other intensive care therapies.
Judith E, Nelson +3 more
openaire +2 more sources
Critical Care, 2023 Background Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may lead to targeted interventions.
Jeremy A. Balch +8 more
doaj +1 more source
Participant retention practices in longitudinal clinical research studies with high retention rates
BMC Medical Research Methodology, 2017 Background There is a need for improving cohort retention in longitudinal studies. Our objective was to identify cohort retention strategies and implementation approaches used in studies with high retention rates.
Martha Abshire +5 more
doaj +1 more source
Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge +6 more
wiley +1 more source