Results 1 to 10 of about 162,344 (302)

Myeloid-derived suppressor cells and associated events in urethane-induced lung cancer [PDF]

Clinics, 2013
OBJECTIVES: Myeloid-derived suppressor cells contribute to the immunosuppressive microenvironment during tumor development and limit the efficacy of cancer immunotherapy.
Daniela Teixeira, Joaquim Soares de Almeida, Bruna Visniauskas, Guiomar Nascimento Gomes, Aparecida Emiko Hirata, Valquiria Bueno   +5 more
doaj   +5 more sources

CD115− monocytic myeloid-derived suppressor cells are precursors of OLFM4high polymorphonuclear myeloid-derived suppressor cells

Communications Biology, 2023
CD115− monocytic MDSCs, functionally distinct from CD115+ monocytic MDSCs, increase in the blood and bone marrow as tumor progresses and can give rise to OLFM4hi polymorphonuclear MDSCs outside the tumor mass.
Yunyun Zou, Nobuhiko Kamada, Seung-Yong Seong, Sang-Uk Seo   +3 more
doaj   +3 more sources

Involvement of increased arginase-1 group 2 innate lymphoid cells and myeloid-derived suppressor cells in endometrial carcinoma: A pilot study [PDF]

Journal of International Medical Research
Background Endometrial carcinoma is a prevalent gynecologic malignancy with a relatively low survival rate. Emerging studies have demonstrated that crosstalk between group 2 innate lymphoid cells (ILC2s) and myeloid-derived suppressor cells drives tumor ...
Zhangyun Gong, Zhimin Lu, Anan Pan, Hao Wang, Haixing Yi, Peipei Guo, Kaihuan Bi, Xuqing Li, Ya Chen, Yuping Xu, Yunxia Cao, Caihua Li, Huanhuan Jiang   +12 more
doaj   +2 more sources

Modulation of T-cell function by myeloid-derived suppressor cells in hematological malignancies

Frontiers in Cell and Developmental Biology, 2023
Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes that negatively regulate the immune response to cancer and chronic infections.
Vaishali Bhardwaj, Stephen M. Ansell
doaj   +1 more source

Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice. [PDF]

PLoS ONE, 2016
To study the impact of psychosocial stress on the immune system, male mice were subjected to chronic subordinate colony housing (CSC), a preclinically validated mouse model for chronic psychosocial stress.
Dominic Schmidt, Daniel Peterlik, Stefan O Reber, Anja Lechner, Daniela N Männel   +4 more
doaj   +1 more source

Expansion of myeloid-derived suppressor cells in the peripheral blood of patients with ankylosing spondylitis

Медицинская иммунология, 2021
Expansion of myeloid-derived suppressor cells (MDSCs) due to impaired differentiation of myeloid progenitor cells under conditions of inflammation was described in a number of autoimmune diseases, including rheumatoid arthritis, systemic lupus ...
A. Yu. Morenkova, M. A. Tikhonova, T. V. Tyrinova, E. V. Batorov, A. E. Sizikov, O. A. Chumasova, A. E. Sulutian, A. A. Ostanin, E. R. Chernykh   +8 more
doaj   +1 more source

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone

Advanced Science, 2022
Atovaquone, an FDA‐approved drug for malaria, is known to inhibit mitochondrial electron transport. A recently synthesized mitochondria‐targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in situ vaccination
Mofei Huang, Donghai Xiong, Jing Pan, Qi Zhang, Yian Wang, Charles R. Myers, Bryon D. Johnson, Micael Hardy, Balaraman Kalyanaraman, Ming You   +9 more
doaj   +1 more source

Analysis of the myeloid-derived suppressor cells and annexin A1 in multibacillary leprosy and reactional episodes

BMC Infectious Diseases, 2021
Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Patients have distinct clinical forms, and the host´s immunological response regulate those manifestations.
Stephanni Figueiredo da Silva, Leticia Rossetto da Silva Cavalcante, Ezequiel Angelo Fonseca Junior, Joselina Maria da Silva, José Cabral Lopes, Amilcar Sabino Damazo   +5 more
doaj   +1 more source

"Open Sesame" to the complexity of pattern recognition receptors of myeloid-derived suppressor cells in cancer

Frontiers in Immunology, 2023
Pattern recognition receptors are primitive sensors that arouse a preconfigured immune response to broad stimuli, including nonself pathogen-associated and autologous damage-associated molecular pattern molecules.
Tian Wang, Yushu Hu, Silvia Dusi, Fang Qi, Silvia Sartoris, Stefano Ugel, Francesco De Sanctis   +6 more
doaj   +1 more source

Role of myeloid-derived suppressor cells in the formation of pre-metastatic niche

Frontiers in Oncology, 2022
Metastasis is a complex process, which depends on the interaction between tumor cells and host organs. Driven by the primary tumor, the host organ will establish an environment suitable for the growth of tumor cells before their arrival, which is called ...
Guoqi Ya, Weihong Ren, Rui Qin, Jiao He, Shuo Zhao   +4 more
doaj   +1 more source