Results 21 to 30 of about 162,344 (302)

Myeloid derived suppressor cells [PDF]

OncoImmunology, 2013
The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs).
Waldron, Todd J., Quatromoni, Jon G., Karakasheva, Tatiana A., Singhal, Sunil, Rustgi, Anil K.   +4 more
openaire   +5 more sources

Immunosuppressive effects and mechanisms of three myeloid-derived suppressor cells subsets including monocytic-myeloid-derived suppressor cells, granulocytic-myeloid-derived suppressor cells, and immature-myeloid-derived suppressor cells

Journal of Cancer Research and Therapeutics, 2021
Context: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immune cells of myeloid lineage. Recent reports have suggested that human MDSC are divided into three subsets: monocytic MDSC (M-MDSC), granulocytic MDSC (G-MDSC), and immature MDSC (I-MDSC). However, the characteristics of each human MDSC subset
Yoshiaki, Nagatani, Yohei, Funakoshi, Hirotaka, Suto, Yoshinori, Imamura, Masanori, Toyoda, Naomi, Kiyota, Kimihiro, Yamashita, Hironobu, Minami   +7 more
openaire   +2 more sources

Myeloid-Derived Suppressor Cells [PDF]

Viral Immunology, 2017
AbstractMyeloid cells developed evolutionarily as a major mechanism to protect the host. They evolved as a critical barrier against infections and are important contributors to tissue remodeling. However, in cancer, myeloid cells are largely converted to serve a new master—tumor cells.
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Myeloid-Derived Suppressor Cells in Sepsis [PDF]

BioMed Research International, 2014
Sepsis is a systemic, deleterious host response to widespread infection. Patients with sepsis will have documented or suspected infection which can progress to a state of septic shock or acute organ dysfunction. Since sepsis is responsible for nearly 3 million cases per year in China and severe sepsis is a common, expensive fatal condition in America ...
Dengming Lai, Chaojin Qin, Qiang Shu
openaire   +2 more sources

Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]

, 2016
Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D., Graham, Laura, Idowu, Michael O., Keim, Rebecca, Manjili, Masoud H., Payne, Kyle K., Toor, Amir A., Wan, Wen, Wang, Xiang-Yang   +8 more
core   +2 more sources

Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma [PDF]

, 2015
Background: Immune markers in the peripheral blood of melanoma patients could provide prognostic information. However, there is currently no consensus on which circulating cell types have more clinical impact.
Bachert, Claus, Brochez, Lieve, CHEVOLET, INES, Krysko, Olga, Neyns, Bart, Schreuer, Max, Speeckaert, Reinhart, van Geel, Nanja, Van Gele, Mireille   +8 more
core   +2 more sources

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study [PDF]

, 2016
There is an increasing interest for monitoring circulating myeloid-derived suppressor cells (MDSCs) in cancer patients, but there are also divergences in their phenotypic definition.
Brandau, Sven, Britten, Cedrik M, Bronte, Vincenzo, Damuzzo, Vera, Gouttefangeas, C\ue9cile, Mandruzzato, Susanna, Maurer, Dominik, Ottensmeier, Christian, van der Burg, Sjoerd H, Walter, Steffen, Welters, Marij J. P   +10 more
core   +2 more sources

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [PDF]

, 2016
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune ...
Brandau, Sven, Bronte, Vincenzo, Chen, Shu Hsia, Colombo, Mario P, Frey, Alan B, Gabrilovich, Dmitry I., Greten, Tim F, Mandruzzato, Susanna, Murray, Peter J, Ochoa, Augusto, Ostrand Rosenberg, Suzanne, Rodriguez, Paulo C, Sica, Antonio, Umansky, Viktor, Vonderheide, Robert H   +14 more
core   +2 more sources

Myeloid-derived suppressor cells and their role in gynecological malignancies

Tumor Biology, 2018
Myeloid-derived suppressor cells are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity (they block the proliferation and activity of both T cells and natural killer cells).
Seiji Mabuchi, Eriko Yokoi, Naoko Komura, Tadashi Kimura   +3 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells in Some Oncohematological Diseases

Клиническая онкогематология, 2017
Myeloid-derived suppressor cells are immature myeloid cells with immunosuppressive properties. The review presents characteristics of myeloid-derived suppressor cells.
Aleksandr Vasil’evich Ponomarev
doaj   +1 more source