Results 21 to 30 of about 7,249,751 (246)
Targeting myeloid-derived suppressor cells augments antitumor activity against lung cancer
ImmunoTargets and Therapy, 2012 Minu K Srivastava,1,2 Li Zhu,1,2 Marni Harris-White,2 Min Huang,1–3 Maie St John,1,3 Jay M Lee,1,3 Ravi Salgia,4 Robert B Cameron,1,3,5 Robert Strieter,6 Steven Dubinett,1–3 Sherven Sharma1–31Department of Medicine, UCLA Lung Cancer ...
Srivastava MK +10 more
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Therapeutic targeting of myeloid-derived suppressor cells
Current Opinion in Pharmacology, 2009 Myeloid-derived suppressor cells (MDSCs) represent a subset of myeloid cells that expand under pathological conditions, such as cancer development, acute and chronic infections, trauma, bone marrow transplantations, and some autoimmune diseases. MDSCs mediate a negative regulation of the immune response by affecting different T lymphocyte subsets ...
Ugel, Stefano +7 more
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EBV and myeloid-derived suppressor cells [PDF]
Blood, 2021 In this issue of Blood, Collins et al have developed a novel multicolor flow cytometry technology to reveal a crucial role of myeloid-derived suppressor cells in Epstein-Barr virus (EBV)-associated lymphoproliferative diseases. In particular this study focuses on EBV-positive natural killer (NK) cell and T-cell proliferation.(1)
Debottam Sinha, Rajiv Khanna
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Myeloid derived suppressor cells [PDF]
OncoImmunology, 2013 The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs).
Waldron, Todd J. +4 more
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Myeloid-Derived Suppressor Cells [PDF]
Viral Immunology, 2017 Abstract Myeloid cells developed evolutionarily as a major mechanism to protect the host. They evolved as a critical barrier against infections and are important contributors to tissue remodeling. However, in cancer, myeloid cells are largely converted to serve a new master—tumor cells.
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Myeloid-Derived Suppressor Cells in Sepsis [PDF]
BioMed Research International, 2014 Sepsis is a systemic, deleterious host response to widespread infection. Patients with sepsis will have documented or suspected infection which can progress to a state of septic shock or acute organ dysfunction. Since sepsis is responsible for nearly 3 million cases per year in China and severe sepsis is a common, expensive fatal condition in America ...
Dengming Lai, Chaojin Qin, Qiang Shu
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Myeloid derived suppressor cells and autoimmunity [PDF]
Human Immunology, 2016 Myeloid-derived suppressor cells are a heterogeneous group of immature myeloid cells with immunoregulatory function. When activated and expanded, these cells can suppress T cell functions via cell-to cell interactions as well as soluble mediators. Recent studies investigated the involvement of MDSC in autoimmune diseases.
Peter, Boros +2 more
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History of myeloid-derived suppressor cells [PDF]
Nature Reviews Cancer, 2013 Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and escape from immunity via T cell suppression. Initially, these myeloid cells were identified as granulocytes or monocytes; however, recent studies have revealed that this hyperplasia is associated with populations of multipotent progenitor cells that have been ...
James E, Talmadge, Dmitry I, Gabrilovich
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Neutrophils as myeloid‐derived suppressor cells [PDF]
European Journal of Clinical Investigation, 2018 AbstractNeutrophils form the first line of defence against invading pathogens, such as bacteria and fungi, as part of the innate immune response. Recently, neutrophils have also been discovered as repressors of adaptive immune responses. Under certain conditions, such as cancer and severe injury, an expansion of immature and mature neutrophils has been
Cathelijn E. M. Aarts, Taco W. Kuijpers
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Myeloid-derived suppressor cells in cancer
iLIVER, 2022 Numerous recent studies have shown that myeloid-derived suppressor cells (MDSCs), a strongly heterogeneous population of immunosuppressive cells, are dysregulated in the presence of many cancers. MDSCs present different phenotypes and play prominent roles in the tumor microenvironment. To date, gene therapies targeting MDSCs are the most innovative and
Gao, Jun +4 more
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