Results 1 to 10 of about 44,768 (301)

Chinese Medicine Formula PSORI-CM02 Alleviates Psoriatic Dermatitis via M-MDSCs and Th17 Crosstalk

Frontiers in Pharmacology, 2021
Psoriasis is a chronic inflammatory skin disease that is associated with multiple coexisting conditions. Extensive literature suggests that psoriasis is a T-cell-mediated condition, and its pathogenesis is related to dysfunction of the immune system ...
Jingwen Deng, Jingwen Deng, Siyi Tan, Ruonan Liu, Wanlin Yu, Haiming Chen, Nan Tang, Ling Han, Ling Han, Chuanjian Lu, Chuanjian Lu   +10 more
doaj   +1 more source

The downregulation of type I IFN signaling in G-MDSCs under tumor conditions promotes their development towards an immunosuppressive phenotype

Cell Death and Disease, 2022
Tumors modify myeloid cell differentiation and induce an immunosuppressive microenvironment. Granulocytic myeloid-derived suppressor cells (G-MDSCs), the main subgroup of myeloid-derived suppressor cells (MDSCs), are immature myeloid cells (IMCs) with ...
Yingying Sun, Xiaoqing Han, Chao Shang, Yawei Wang, Boya Xu, Shu Jiang, Yan Mo, Dake Wang, Yueshuang Ke, Xianlu Zeng   +9 more
doaj   +1 more source

Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression

Frontiers in Immunology, 2022
Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of immature myeloid cells and exhibit obvious immunomodulatory functions.
Zhuang Chen, Rui Yuan, Shengyun Hu, Weitang Yuan, Zhenqiang Sun   +4 more
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Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy

Frontiers in Immunology, 2021
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that are activated under pathological conditions, such as cancer, or mature myeloid cells that are converted immune-suppressive cells via tumor-derived ...
Xueyan Li, Xueyan Li, Jiahui Zhong, Xue Deng, Xuan Guo, Yantong Lu, Juze Lin, Xuhui Huang, Changjun Wang, Changjun Wang   +9 more
doaj   +1 more source

Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

Cells, 2021
The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in ...
Mithunah Krishnamoorthy, Lara Gerhardt, Saman Maleki Vareki   +2 more
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The Function and Therapeutic Implications of TNF Signaling in MDSCs

Biomolecules, 2022
Myeloid-derived suppressor cells (MDSCs) are a group of immature and heterogeneous myeloid cells with immunosuppressive functions. MDSCs play important roles in the pathogenesis of cancer, chronic inflammatory diseases, and many autoimmune disorders. The
Kun Yu, Chengxin Yu, Liping Jiao, Kun Miao, Li Ni, Xiaoquan Rao, Ling Zhou, Chunxia Zhao   +7 more
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Modulation of T-cell function by myeloid-derived suppressor cells in hematological malignancies

Frontiers in Cell and Developmental Biology, 2023
Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes that negatively regulate the immune response to cancer and chronic infections.
Vaishali Bhardwaj, Stephen M. Ansell
doaj   +1 more source

Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma [PDF]

, 2015
Background: Immune markers in the peripheral blood of melanoma patients could provide prognostic information. However, there is currently no consensus on which circulating cell types have more clinical impact.
Bachert, Claus, Brochez, Lieve, CHEVOLET, INES, Krysko, Olga, Neyns, Bart, Schreuer, Max, Speeckaert, Reinhart, van Geel, Nanja, Van Gele, Mireille   +8 more
core   +4 more sources

Translocation of Helicobacter hepaticus synergizes with myeloid-derived suppressor cells and contributes to breast carcinogenesis

OncoImmunology, 2022
Microbial dysbiosis plays an important role in the development of intestinal diseases. Recent studies suggest a link between intestinal bacteria and mammary cancer.
Huan Deng, Sureshkumar Muthupalani, Susan Erdman, Haibo Liu, Zhengchuan Niu, Timothy C. Wang, James G. Fox   +6 more
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Increased Frequency of Myeloid-Derived Suppressor Cells in Myasthenia Gravis After Immunotherapy

Frontiers in Neurology, 2022
Myeloid-derived suppressor cells (MDSCs) are a population of myeloid progenitor cells with immunoregulatory functions and their role in myasthenia gravis (MG) was unknown.
Yan Wang, Chong Yan, Chong Yan, Caixia Su, Ying Wang, Sushan Luo, Sushan Luo, Jun Lu, Jun Lu, Chongbo Zhao, Chongbo Zhao, Gan Zhao, Jianying Xi, Jianying Xi   +13 more
doaj   +1 more source