Results 1 to 10 of about 51,191 (308)
LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2
Journal of Hematology and Oncology, 2021 Myeloid-derived suppressor cells (MDSCs) are derived from bone marrow progenitor cells commonly, which is a heterogeneous cell group composed of immature granulocytes, dendritic cells, macrophages and early undifferentiated bone marrow precursor cells ...
Wei Lu, Yi Chang, Ying Chu
exaly +2 more sources
OncoImmunology, 2018 Myeloid-derived suppressor cells (MDSCs) have been shown to contribute to tumor progression, mainly through immune suppression. Inverse correlations have been observed between MDSC levels and patient survival for various malignancies. The purpose of this
Shou-Wei Li
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Early predictors of efficacy of biological therapy for psoriasis in children
Аллергология и Иммунология в Педиатрии, 2023 .
D. G. Kuptsova +4 more
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MDSCs: The Key Players in the Formation of Pre-Metastatic Niche
Frontiers in Bioscience-Landmark, 2023 The distal metastasis of tumor cells is viewed as a series of concurrent processes rather than a linear cascade of events. Accompanied with the progression of the primary tumor, a favorable microenvironment, refered as pre-metastatic niche, has been ...
Weigang Cui +4 more
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Targeting myeloid-derived suppressor cells for cancer therapy
Cancer Biology & Medicine, 2021 The emergence and clinical application of immunotherapy is considered a promising breakthrough in cancer treatment. According to the literature, immune checkpoint blockade (ICB) has achieved positive clinical responses in different cancer types, although
Hongchao Tang, Hao Li, Zhijun Sun
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HMGB1 Signaling-Mediated Tumor Immunity in Cancer Progress
Frontiers in Bioscience-Landmark, 2023 Tumor immunity is a cycle that begins with the release of antigens from tumor cells and ends with the destruction of tumor cells. High mobility group box 1 (HMGB1) is a nonhistone protein widely present in the nucleus of mammalian cells and can be ...
Jinlin Wen, Xinyan Zhang
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OncoImmunology, 2020 Blockade of the PD-1 receptor has revolutionized the treatment of metastatic melanoma, with significant increases in overall survival (OS) and a dramatic improvement in patient quality of life.
Yago Pico de Coaña +8 more
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OncoImmunology, 2021 Numerous studies have found that chronic stress could promote tumor progression and this may be related to inhibtion of immune system. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells with immunosuppressive activity. MDSCs
Jiale an +16 more
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OncoImmunology, 2020 Antibodies targeting the co-inhibitory receptor programmed cell death 1 (PDCD1, best known as PD-1) or its main ligand CD274 (best known as PD-L1) have shown some activity in patients with metastatic triple-negative breast cancer (TNBC), especially in a ...
Karsten A. Pilones +7 more
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OncoImmunology, 2021 Although all murine MDSCs are defined as Gr1+CD11b+, their true immunophenotype remains elusive. In this study, we found murine Gr1+CD11b+ cells can be divided into two subsets: Gr1+CD11b+B220− and Gr1+CD11b+B220+, especially in the spleen tissues ...
Zhiqian Zhang +4 more
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