Results 41 to 50 of about 51,191 (308)

Transcriptomic Analyses of Myeloid-Derived Suppressor Cell Subsets in the Circulation of Colorectal Cancer Patients

Frontiers in Oncology, 2020
Myeloid-derived suppressor cells (MDSCs) promote tumor immune evasion and favor tumorigenesis by activating various tumor-promoting downstream signals. MDSC expansion is evident in the circulation and tumor microenvironment of many solid tumors including
Varun Sasidharan Nair, Reem Saleh, Salman M. Toor, Nehad M. Alajez, Eyad Elkord   +4 more
doaj   +1 more source

Role of mTOR signaling in tumor microenvironment. An overview [PDF]

, 2018
The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara, Bria, Emilio, Ciuffreda, L., Cognetti, F., COGNETTI, FRANCESCO, Conciatori, Fabiana, Falcone, I., Milella, M., Pilotto, Sara   +8 more
core   +2 more sources

MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

Frontiers in Oncology, 2022
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature cells derived from bone marrow that play critical immunosuppressive functions in the tumor microenvironment (TME), promoting cancer progression. According to base length, Non-coding RNAs (ncRNAs) are mainly divided into: microRNAs (miRNAs), lncRNAs, snRNAs and CircRNAs. Both
Xiaocui Liu, Shang Zhao, Hongshu Sui, Hui Liu, Minhua Yao, Yanping Su, Peng Qu, Peng Qu   +7 more
openaire   +3 more sources

Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12 [PDF]

, 2011
Immunotherapy-based strategies for gastrointestinal carcinomas (GIC) have been exploited so far, but these approaches have to face strong mechanisms of immune escape induced by tumours.
Alaniz, Almand, Appay, Barajas, Bell, Beyer, Bluestone, Brodsky, Bronte, Caruso, Catalina Atorrasagasti, Clark, Colombo, Colvin, Croci, Curiel, Dieckmann, Elkord, Ferlay, Flavia Piccioni, Gabrilovich, Gabrilovich, Ghiringhelli, Ghiringhelli, Gomez, Guillermo Mazzolini, Haigh, Huang, Jaime A. Espinoza, Jorge B. Aquino, Juan Bayo, Kerkar, Ko, Larmonier, Laura Alaniz, Leonard, Lorenz, Malvicini, Manuel Gidekel, Mariana Garcia, Mariana Ingolotti, Mariana Malvicini, Matar, Mazzolini, Mazzolini, Mazzolini, Medina-Echeverz, Melero, Nestle, O. Graciela Scharovsky, Onishi, Ormandy, Pablo Matar, Proietti, Putzer, Rabinovich, Sakaguchi, Sangro, Shapira, Spaapen, Suzuki, Takahashi, Tang, Thornton, Trinchieri, Vignali, Yokoyama, Zou, Zou, Zwirner   +69 more
core   +1 more source

Blocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade

OncoImmunology, 2017
Anti-PD-1/PD-L1 therapy has achieved great success in the clinic; however, only a small fraction of cancer patient benefit from PD-1/PD-L1 blockade therapy, and overcoming resistance to PD-1/PD-L1 blockade has thus become a primary priority.
Haoran Zha, Xiao Han, Ying Zhu, Fei Yang, Yongsheng Li, Qijing Li, Bo Guo, Bo Zhu   +7 more
doaj   +1 more source

Acitretin Promotes the Differentiation of Myeloid-Derived Suppressor Cells in the Treatment of Psoriasis

Frontiers in Medicine, 2021
Increased numbers of myeloid-derived suppressor cells (MDSCs) are involved in the development of psoriasis. Acitretin is used to treat psoriasis by regulating the proliferation and differentiation of keratinocytes, but little is known about the effect of
Panpan Liu, Panpan Liu, Panpan Liu, Cong Peng, Cong Peng, Cong Peng, Xiang Chen, Xiang Chen, Xiang Chen, Xiang Chen, Lisha Wu, Lisha Wu, Lisha Wu, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin, Jie Li, Jie Li, Jie Li, Qunshi Qin, Qunshi Qin, Qunshi Qin, Yehong Kuang, Yehong Kuang, Yehong Kuang, Wu Zhu, Wu Zhu, Wu Zhu, Wu Zhu   +28 more
doaj   +1 more source

Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice [PDF]

, 2012
The use of conventional cytotoxic agents at metronomic schedules, alone or in combination with targeted agents or immunotherapy, is being explored as a promising anticancer strategy.
Alaniz, Laura Daniela, Aquino, Jorge Benjamin, Atorrasagasti, María Catalina, Bayo Fina, Juan Miguel, Fiore, Esteban Juan, García, Mariana Gabriela, Malvicini, Mariana, Matar, Pablo, Mazzolini Rizzo, Guillermo Daniel, Piccioni, Flavia Valeria   +9 more
core   +1 more source

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]

, 2015
Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation.
Agostinis, C, Botto, M, Bulla, R, Durigutto, P, Guarnotta, C, Ling, GS, Rami, D, Tedesco, F, Tripodo, C, Zorzet, S   +9 more
core   +3 more sources

Embelin impairs the accumulation and activation of MDSCs in colitis-associated tumorigenesis

OncoImmunology, 2018
Myeloid-derived suppressor cells (MDSCs) are a major component of the immunosuppressive tumor microenvironment and has been recognized as a contributing factor for inflammation-related cancers.
Ting Wu, Chaohui Wang, Weihong Wang, Yuhang Hui, Rongxin Zhang, Liang Qiao, Yun Dai   +6 more
doaj   +1 more source

Endoplasmic reticulum stress mediates the myeloid-derived immune suppression associated with cancer and infectious disease

Journal of Translational Medicine, 2023
Myeloid-derived suppressor cells (MDSCs), which are immature heterogeneous bone marrow cells, have been described as potent immune regulators in human and murine cancer models.
Xiaoli Lou, Deyong Gao, Liyuan Yang, Yue Wang, Yanqiang Hou   +4 more
doaj   +1 more source