Immunosuppression - Open Access .click

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Identification of a sub-group of critically ill patients with high risk of intensive care unit-acquired infections and poor clinical course using a transcriptomic score

Critical Care, 2023
Background The development of stratification tools based on the assessment of circulating mRNA of genes involved in the immune response is constrained by the heterogeneity of septic patients.
Maxime Bodinier +12 more
doaj +1 more source

Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients

Annals of Intensive Care, 2022
Background Lymphopenia is a hallmark of severe coronavirus disease 19 (COVID-19). Similar alterations have been described in bacterial sepsis and therapeutic strategies targeting T cell function such as recombinant human interleukin 7 (rhIL-7) have been ...
Frank Bidar +17 more
doaj +1 more source

A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score

Annals of Intensive Care, 2022
Background Although multiple individual immune parameters have been demonstrated to predict the occurrence of secondary infection after critical illness, significant questions remain with regards to the selection, timing and clinical utility of such ...
Jan-Alexis Tremblay +12 more
doaj +1 more source

Interferon gamma as an immune modulating adjunct therapy for invasive mucormycosis after severe burn – A case report

Frontiers in Immunology, 2022
BackgroundMucormycosis is a deadly fungal infection that mainly affects severely immunocompromised patients. We report herein the case of a previously immunocompetent adult woman who developed invasive cutaneous mucormycosis after severe burn injuries ...
Dina M. Tawfik +22 more
doaj +1 more source

Characterization of Circulating IL-10-Producing Cells in Septic Shock Patients: A Proof of Concept Study

Frontiers in Immunology, 2021
Sepsis is a worldwide health priority characterized by the occurrence of severe immunosuppression associated with increased risk of death and secondary infections.
Astrid Fabri +18 more
doaj +1 more source

Mortality Prediction in Sepsis With an Immune-Related Transcriptomics Signature: A Multi-Cohort Analysis

Frontiers in Medicine, 2022
BackgroundNovel biomarkers are needed to progress toward individualized patient care in sepsis. The immune profiling panel (IPP) prototype has been designed as a fully-automated multiplex tool measuring expression levels of 26 genes in sepsis patients to
Louis Kreitmann +25 more
doaj +1 more source

TCR activation mimics CD127lowPD-1high phenotype and functional alterations of T lymphocytes from septic shock patients

Critical Care, 2019
Background Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death.
Julie Mouillaux +10 more
doaj +1 more source

A novel virotherapy encoding human interleukin-7 improves ex vivo T lymphocyte functions in immunosuppressed patients with septic shock and critically ill COVID-19

Frontiers in Immunology, 2022
A majority of patients with sepsis surviving the first days in intensive care units (ICU) enter a state of immunosuppression contributing to their worsening.
Morgane Crausaz +11 more
doaj +1 more source

Dynamic LTR retrotransposon transcriptome landscape in septic shock patients

Critical Care, 2020
Background Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have explored the complex and dynamic transcriptome modulations observed in sepsis patients, but a large fraction ...
Marine Mommert +15 more
doaj +1 more source

Herpes DNAemia and TTV Viraemia in Intensive Care Unit Critically Ill Patients: A Single-Centre Prospective Longitudinal Study

Frontiers in Immunology, 2021
IntroductionWe analysed blood DNAemia of TTV and four herpesviruses (CMV, EBV, HHV6, and HSV-1) in the REAnimation Low Immune Status Marker (REALISM) cohort of critically ill patients who had presented with either sepsis, burns, severe trauma, or major ...
François Mallet +18 more
doaj +1 more source

sepsis
medicine
liver transplantation

hla-dr
mortality
critical care

flow cytometry
first aid
intensive care