Results 1 to 10 of about 282,999 (266)

Immediate and Gradual Withdrawal of Immunosuppression After Kidney Graft Loss Lead to Similar Outcomes. [PDF]

Transpl Int
The management of immunosuppression in dialysis patients with a failed kidney transplant remains a pending question, and different approaches to immunosuppression weaning have been proposed.
Nabil A, Congy-Jolivet N, Darres A, Guy P, Marion O, Milhes J, Prudhomme T, Kamar N, Del Bello A.   +8 more
europepmc   +2 more sources

Identification of a sub-group of critically ill patients with high risk of intensive care unit-acquired infections and poor clinical course using a transcriptomic score

Critical Care, 2023
Background The development of stratification tools based on the assessment of circulating mRNA of genes involved in the immune response is constrained by the heterogeneity of septic patients.
Maxime Bodinier, Guillaume Monneret, Marie Casimir, Aurore Fleurie, Filippo Conti, Fabienne Venet, Marie-Angélique Cazalis, Elisabeth Cerrato, Estelle Peronnet, Thomas Rimmelé, Anne-Claire Lukaszewicz, Karen Brengel-Pesce, Jean-François Llitjos   +12 more
doaj   +1 more source

Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients

Annals of Intensive Care, 2022
Background Lymphopenia is a hallmark of severe coronavirus disease 19 (COVID-19). Similar alterations have been described in bacterial sepsis and therapeutic strategies targeting T cell function such as recombinant human interleukin 7 (rhIL-7) have been ...
Frank Bidar, Sarah Hamada, Morgane Gossez, Remy Coudereau, Jonathan Lopez, Marie-Angelique Cazalis, Claire Tardiveau, Karen Brengel-Pesce, Marine Mommert, Marielle Buisson, Filippo Conti, Thomas Rimmelé, Anne-Claire Lukaszewicz, Laurent Argaud, Martin Cour, Guillaume Monneret, Fabienne Venet, RICO Study Group   +17 more
doaj   +1 more source

A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score

Annals of Intensive Care, 2022
Background Although multiple individual immune parameters have been demonstrated to predict the occurrence of secondary infection after critical illness, significant questions remain with regards to the selection, timing and clinical utility of such ...
Jan-Alexis Tremblay, Florian Peron, Louis Kreitmann, Julien Textoris, Karen Brengel-Pesce, Anne-Claire Lukaszewicz, Laurence Quemeneur, Christophe Vedrine, Lionel K. Tan, Fabienne Venet, Thomas Rimmele, Guillaume Monneret, the REALISM study group   +12 more
doaj   +1 more source

Interferon gamma as an immune modulating adjunct therapy for invasive mucormycosis after severe burn – A case report

Frontiers in Immunology, 2022
BackgroundMucormycosis is a deadly fungal infection that mainly affects severely immunocompromised patients. We report herein the case of a previously immunocompetent adult woman who developed invasive cutaneous mucormycosis after severe burn injuries ...
Dina M. Tawfik, Dina M. Tawfik, Caroline Dereux, Caroline Dereux, Jan-Alexis Tremblay, Jan-Alexis Tremblay, Andre Boibieux, Fabienne Braye, Jean-Baptiste Cazauran, Meja Rabodonirina, Elisabeth Cerrato, Elisabeth Cerrato, Audrey Guichard, Audrey Guichard, Fabienne Venet, Fabienne Venet, Guillaume Monneret, Guillaume Monneret, Didier Payen, Anne-Claire Lukaszewicz, Anne-Claire Lukaszewicz, Julien Textoris, Julien Textoris   +22 more
doaj   +1 more source

Characterization of Circulating IL-10-Producing Cells in Septic Shock Patients: A Proof of Concept Study

Frontiers in Immunology, 2021
Sepsis is a worldwide health priority characterized by the occurrence of severe immunosuppression associated with increased risk of death and secondary infections.
Astrid Fabri, Astrid Fabri, Khalil Kandara, Khalil Kandara, Rémy Coudereau, Rémy Coudereau, Morgane Gossez, Morgane Gossez, Paul Abraham, Céline Monard, Céline Monard, Martin Cour, Thomas Rimmelé, Thomas Rimmelé, Laurent Argaud, Guillaume Monneret, Guillaume Monneret, Fabienne Venet, Fabienne Venet   +18 more
doaj   +1 more source

Melanoma and Immunosuppression [PDF]

Dermatology, 2009
In a recent article, Richtig et al. [1] suggested that immunosuppression may be a risk factor for melanoma development and, in order to support this view, cited a study demonstrating an increased frequency of melanoma in organ transplant recipients receiving long-term immunosuppression [2] .
Belloni Fortina A, PIASERICO, STEFANO, Tonin E, ALAIBAC, MAURO SALVATORE ALESSANDRO, BELLONI FORTINA, ANNA   +4 more
openaire   +3 more sources

Mortality Prediction in Sepsis With an Immune-Related Transcriptomics Signature: A Multi-Cohort Analysis

Frontiers in Medicine, 2022
BackgroundNovel biomarkers are needed to progress toward individualized patient care in sepsis. The immune profiling panel (IPP) prototype has been designed as a fully-automated multiplex tool measuring expression levels of 26 genes in sepsis patients to
Louis Kreitmann, Louis Kreitmann, Maxime Bodinier, Maxime Bodinier, Aurore Fleurie, Aurore Fleurie, Katia Imhoff, Marie-Angelique Cazalis, Marie-Angelique Cazalis, Estelle Peronnet, Estelle Peronnet, Elisabeth Cerrato, Elisabeth Cerrato, Claire Tardiveau, Claire Tardiveau, Filippo Conti, Filippo Conti, Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos, Julien Textoris, Guillaume Monneret, Guillaume Monneret, Sophie Blein, Karen Brengel-Pesce, Karen Brengel-Pesce   +25 more
doaj   +1 more source

Macromolecular Immunosuppressants [PDF]

Biotechnology Journal, 2005
AbstractRecombinant immunosuppressants have come of age and represent a significant class of quite diverse drugs. They target extracellular molecules, and either label or inhibit them. Those targets are soluble factors or membrane proteins almost all of which are components of a very complex molecular network of communication and amplification. Notably,
Theo, Dingermann, Ilse, Zündorf
openaire   +2 more sources

TCR activation mimics CD127lowPD-1high phenotype and functional alterations of T lymphocytes from septic shock patients

Critical Care, 2019
Background Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death.
Julie Mouillaux, Camille Allam, Morgane Gossez, Thomas Uberti, Benjamin Delwarde, Jack Hayman, Thomas Rimmelé, Julien Textoris, Guillaume Monneret, Estelle Peronnet, Fabienne Venet   +10 more
doaj   +1 more source