Results 11 to 20 of about 282,999 (266)

A novel virotherapy encoding human interleukin-7 improves ex vivo T lymphocyte functions in immunosuppressed patients with septic shock and critically ill COVID-19

Frontiers in Immunology, 2022
A majority of patients with sepsis surviving the first days in intensive care units (ICU) enter a state of immunosuppression contributing to their worsening.
Morgane Crausaz, Morgane Crausaz, Guillaume Monneret, Guillaume Monneret, Filippo Conti, Anne-Claire Lukaszewicz, Anne-Claire Lukaszewicz, Jean-Baptiste Marchand, Perrine Martin, Geneviève Inchauspé, Fabienne Venet, Fabienne Venet   +11 more
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Immunosuppressants

Journal of the California Dental Association, 2008
This paper provides a brief introduction to some of the common immunosuppressants used in oral medicine, the prevention and treatment of oral adverse effects of immunosuppressants, and considerations for dental treatment in patients taking immunosuppressants.
Nita, Chainani-Wu, Timothy C, Wu
openaire   +2 more sources

Dynamic LTR retrotransposon transcriptome landscape in septic shock patients

Critical Care, 2020
Background Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have explored the complex and dynamic transcriptome modulations observed in sepsis patients, but a large fraction ...
Marine Mommert, Olivier Tabone, Audrey Guichard, Guy Oriol, Elisabeth Cerrato, Mélanie Denizot, Valérie Cheynet, Alexandre Pachot, Alain Lepape, Guillaume Monneret, Fabienne Venet, Karen Brengel-Pesce, Julien Textoris, François Mallet, MIPrea Study Group, REALISM Study Group   +15 more
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Herpes DNAemia and TTV Viraemia in Intensive Care Unit Critically Ill Patients: A Single-Centre Prospective Longitudinal Study

Frontiers in Immunology, 2021
IntroductionWe analysed blood DNAemia of TTV and four herpesviruses (CMV, EBV, HHV6, and HSV-1) in the REAnimation Low Immune Status Marker (REALISM) cohort of critically ill patients who had presented with either sepsis, burns, severe trauma, or major ...
François Mallet, Léa Diouf, Léa Diouf, Boris Meunier, Boris Meunier, Magali Perret, Frédéric Reynier, Philippe Leissner, Laurence Quemeneur, Andrew D. Griffiths, Virginie Moucadel, Alexandre Pachot, Fabienne Venet, Guillaume Monneret, Alain Lepape, Thomas Rimmelé, Lionel K. Tan, Karen Brengel-Pesce, Julien Textoris   +18 more
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Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes

Critical Care, 2020
Background Decreased monocytic (m)HLA-DR expression is the most studied biomarker of sepsis-induced immunosuppression. To date, little is known about the relationship between sepsis characteristics, such as the site of infection, causative pathogen, or ...
Guus P. Leijte, Thomas Rimmelé, Matthijs Kox, Niklas Bruse, Céline Monard, Morgane Gossez, Guillaume Monneret, Peter Pickkers, Fabienne Venet   +8 more
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Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients

Frontiers in Immunology, 2021
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner.
Maxime Bodinier, Estelle Peronnet, Karen Brengel-Pesce, Filippo Conti, Thomas Rimmelé, Julien Textoris, Christophe Vedrine, Laurence Quemeneur, Andrew D. Griffiths, Lionel K. Tan, Fabienne Venet, Fabienne Venet, Delphine Maucort-Boulch, Delphine Maucort-Boulch, Delphine Maucort-Boulch, Guillaume Monneret, the REALISM study group   +16 more
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To be (immunosuppressive) or not to be [PDF]

Nature Reviews Cancer, 2019
Singhal et al. characterized tumour-infiltrating monocyte and macrophage lineage cells in patients with early stage lung cancer and found that, contrary to data in mouse models, the function of these cells might not be primarily immunosuppressive.
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A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients

Frontiers in Immunology, 2022
Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex
Claire Tardiveau, Claire Tardiveau, Guillaume Monneret, Guillaume Monneret, Anne-Claire Lukaszewicz, Anne-Claire Lukaszewicz, Valérie Cheynet, Valérie Cheynet, Elisabeth Cerrato, Elisabeth Cerrato, Katia Imhoff, Katia Imhoff, Estelle Peronnet, Estelle Peronnet, Maxime Bodinier, Maxime Bodinier, Louis Kreitmann, Louis Kreitmann, Sophie Blein, Sophie Blein, Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos, Filippo Conti, Filippo Conti, Morgane Gossez, Morgane Gossez, Marielle Buisson, Hodane Yonis, Martin Cour, Laurent Argaud, Marie-Charlotte Delignette, Florent Wallet, Frederic Dailler, Céline Monard, Karen Brengel-Pesce, Karen Brengel-Pesce, Fabienne Venet, Fabienne Venet, the RICO study group   +39 more
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Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial

Critical Care, 2017
Background Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we
Jonathan Plassais, Fabienne Venet, Marie-Angélique Cazalis, Diane Le Quang, Alexandre Pachot, Guillaume Monneret, Sylvie Tissot, Julien Textoris   +7 more
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Early herpes and TTV DNAemia in septic shock patients: a pilot study

Intensive Care Medicine Experimental, 2019
Background Septic shock patients exhibit an increased incidence of viral reactivation. Precise timing of such reactivation—as an early marker of immune suppression, or as a consequence of the later—is not known precisely.
François Mallet, Magali Perret, Trang Tran, Boris Meunier, Audrey Guichard, Olivier Tabone, Marine Mommert, Karen Brengel-Pesce, Fabienne Venet, Alexandre Pachot, Guillaume Monneret, Frederic Reynier, Christophe Védrine, Philippe Leissner, Virginie Moucadel, Alain Lepape, Julien Textoris, MIPrea group, REALISM group   +18 more
doaj   +1 more source