Results 21 to 30 of about 282,999 (266)

Understanding sepsis-induced immunosuppression and organ dysfunctions: from immunosuppression to immunotherapy

Exploration of Immunology, 2022
Sepsis is a life-threatening condition caused by dysregulated host immune response to infection, leading to persistent inflammation followed by immunosuppression.
Dablu Lal Gupta, Tejprakash Sinha, Richa Pathak, Sanjeev Bhoi, D. N. Rao   +4 more
doaj   +1 more source

Generic immunosuppressants

Pediatric Nephrology, 2017
Immunosuppressive drugs for solid organ transplantation are critical dose drugs with a narrow therapeutic index. Many of the most commonly used innovator drugs are off patent and have been replicated by generic counterparts, often at substantial cost-savings to the patient.
Mara Medeiros, Julia Lumini, Noah Stern, Gilberto Castañeda-Hernández, Guido Filler   +4 more
openaire   +5 more sources

The Mechanism of Mori Folium and Eucommiae Cortex against Cyclophosphamide-Induced Immunosuppression Integrating Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation

Metabolites, 2023
It has been reported that Mori Folium (MF) and Eucommiae Cortex (EC) exhibit pharmacological effects in the treatment of immunosuppression. However, the mechanism of MF and EC against immunosuppression remains unclear.
Jinde Liu, Qiao Rong, Chunxiao Zhang, Ali Tariq, Lin Li, Yongning Wu, Feifei Sun   +6 more
doaj   +1 more source

Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn

Frontiers in Immunology, 2019
Although human endogenous retroviruses (HERVs) expression is a growing subject of interest, no study focused before on specific endogenous retroviruses loci activation in severely injured patients.
Olivier Tabone, Marine Mommert, Marine Mommert, Camille Jourdan, Elisabeth Cerrato, Matthieu Legrand, Alain Lepape, Bernard Allaouchiche, Bernard Allaouchiche, Thomas Rimmelé, Alexandre Pachot, Guillaume Monneret, Guillaume Monneret, Fabienne Venet, Fabienne Venet, François Mallet, François Mallet, Julien Textoris, Julien Textoris   +18 more
doaj   +1 more source

Effect of Maintaining Immunosuppression After Kidney Allograft Failure on Mortality and Retransplantation

Transplantation Direct, 2023
Background. Few studies have addressed immunosuppression management after allograft failure (AF). Immunosuppression withdrawal to minimize complications must be balanced with the risk of sensitization and potentially reduced retransplantation.
Suryanarayanan Balakrishnan, MD, Byron Smith, PhD, MS, Andrew Bentall, MD, Aleksandra Kukla, MD, Massini Merzkani, MD, Mark Stegall, MD, Carrie Schinstock, MD   +6 more
doaj   +1 more source

T cell response against SARS-CoV-2 persists after one year in patients surviving severe COVID-19

EBioMedicine, 2022
Summary: Background: In critically ill COVID-19 patients, the initial response to SARS-CoV-2 infection is characterized by major immune dysfunctions.
Fabienne Venet, Morgane Gossez, Frank Bidar, Maxime Bodinier, Rémy Coudereau, Anne-Claire Lukaszewicz, Claire Tardiveau, Karen Brengel-Pesce, Valérie Cheynet, Marie-Angélique Cazalis, Rémi Pescarmona, Lorna Garnier, Marine Ortillon, Marielle Buisson, Maude Bouscambert-Duchamp, Florence Morfin-Sherpa, Jean-Sébastien Casalegno, Filippo Conti, Thomas Rimmelé, Laurent Argaud, Martin Cour, Mitra Saadatian-Elahi, Laetitia Henaff, Philippe Vanhems, Guillaume Monneret   +24 more
doaj   +1 more source

LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs

BMC Genomics, 2018
Background Human Endogenous Retroviruses (HERVs) and Mammalian apparent LTR-retrotransposons (MaLRs) represent the 8% of our genome and are distributed among our 46 chromosomes.
Marine Mommert, Olivier Tabone, Guy Oriol, Elisabeth Cerrato, Audrey Guichard, Magali Naville, Paola Fournier, Jean-Nicolas Volff, Alexandre Pachot, Guillaume Monneret, Fabienne Venet, Karen Brengel-Pesce, Julien Textoris, François Mallet   +13 more
doaj   +1 more source

Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome

Critical Care, 2021
Background Since the onset of the pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may last for several weeks ...
Fabienne Venet, Martin Cour, Thomas Rimmelé, Sebastien Viel, Hodane Yonis, Remy Coudereau, Camille Amaz, Paul Abraham, Céline Monard, Jean-Sebastien Casalegno, Karen Brengel-Pesce, Anne-Claire Lukaszewicz, Laurent Argaud, Guillaume Monneret, the RICO study group   +14 more
doaj   +1 more source

Induction immunosuppression and post-transplant diabetes mellitus: a propensity-matched cohort study

Frontiers in Endocrinology, 2023
IntroductionPost-transplant diabetes mellitus (PTDM) is a common complication among cardiac transplant recipients, causing diabetes-related complications and death.
Suruchi K. Gupta, Suruchi K. Gupta, Suruchi K. Gupta, Elizabeth Mostofsky, Shweta R. Motiwala, Shweta R. Motiwala, Ali Hage, Ali Hage, Murray A. Mittleman, Murray A. Mittleman, Murray A. Mittleman   +10 more
doaj   +1 more source

Continuation of immunosuppression vs. immunosuppression weaning in potential repeat kidney transplant candidates: a care management perspective

Frontiers in Nephrology, 2023
Management of immunosuppression in patients with a failing or failed kidney transplant requires a complete assessment of their clinical condition. One of the major considerations in determining immunosuppression is whether or not such an individual is ...
Michelle J. Hickey, Gurbir Singh, Erik L. Lum   +2 more
doaj   +1 more source