Results 21 to 30 of about 74,169 (245)

A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Christopher M. Fanger, Khoury, Rosana M, Negulescu, Paul A, Cahalan, Michael D, Neben, Amber L, Hubert H. Kerschbaum, Fanger, Christopher M, Rosana M. Khoury, Kerschbaum, Hubert H, Claudia Eder, Amber L. Neben, George R. Ehring, Eder, Claudia, Michael D. Cahalan, Paul A. Negulescu, Ehring, George R, Negulescu, PA, Fanger, CM, Kerschbaum, HH, Khoury, RM, Ehring, GR, Eder, C, Cahalan, MD, Neben, AL   +23 more
core   +1 more source

To be (immunosuppressive) or not to be [PDF]

Nature Reviews Cancer, 2019
Singhal et al. characterized tumour-infiltrating monocyte and macrophage lineage cells in patients with early stage lung cancer and found that, contrary to data in mouse models, the function of these cells might not be primarily immunosuppressive.
openaire   +2 more sources

Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes

Critical Care, 2020
Background Decreased monocytic (m)HLA-DR expression is the most studied biomarker of sepsis-induced immunosuppression. To date, little is known about the relationship between sepsis characteristics, such as the site of infection, causative pathogen, or ...
Guus P. Leijte, Thomas Rimmelé, Matthijs Kox, Niklas Bruse, Céline Monard, Morgane Gossez, Guillaume Monneret, Peter Pickkers, Fabienne Venet   +8 more
doaj   +1 more source

Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients

Frontiers in Immunology, 2021
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner.
Maxime Bodinier, Estelle Peronnet, Karen Brengel-Pesce, Filippo Conti, Thomas Rimmelé, Julien Textoris, Christophe Vedrine, Laurence Quemeneur, Andrew D. Griffiths, Lionel K. Tan, Fabienne Venet, Fabienne Venet, Delphine Maucort-Boulch, Delphine Maucort-Boulch, Delphine Maucort-Boulch, Guillaume Monneret, the REALISM study group   +16 more
doaj   +1 more source

Mesenchymal stem cell-mediated T cell immunosuppression [PDF]

, 2017
Besides being a pool forstromal cells and connective tissues, the mesenchymal stem cells (MSCs) as well exert a potent immunosuppression against almost all types of immune cells, particularly T cells.
Al-Graittee, Satar Jabbar Rahi, Ramasamy, Rajesh, Lawal, Hamza   +2 more
core   +1 more source

A 9-mRNA signature measured from whole blood by a prototype PCR panel predicts 28-day mortality upon admission of critically ill COVID-19 patients

Frontiers in Immunology, 2022
Immune responses affiliated with COVID-19 severity have been characterized and associated with deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex
Claire Tardiveau, Claire Tardiveau, Guillaume Monneret, Guillaume Monneret, Anne-Claire Lukaszewicz, Anne-Claire Lukaszewicz, Valérie Cheynet, Valérie Cheynet, Elisabeth Cerrato, Elisabeth Cerrato, Katia Imhoff, Katia Imhoff, Estelle Peronnet, Estelle Peronnet, Maxime Bodinier, Maxime Bodinier, Louis Kreitmann, Louis Kreitmann, Sophie Blein, Sophie Blein, Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos, Filippo Conti, Filippo Conti, Morgane Gossez, Morgane Gossez, Marielle Buisson, Hodane Yonis, Martin Cour, Laurent Argaud, Marie-Charlotte Delignette, Florent Wallet, Frederic Dailler, Céline Monard, Karen Brengel-Pesce, Karen Brengel-Pesce, Fabienne Venet, Fabienne Venet, the RICO study group   +39 more
doaj   +1 more source

Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial

Critical Care, 2017
Background Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we
Jonathan Plassais, Fabienne Venet, Marie-Angélique Cazalis, Diane Le Quang, Alexandre Pachot, Guillaume Monneret, Sylvie Tissot, Julien Textoris   +7 more
doaj   +1 more source

Early herpes and TTV DNAemia in septic shock patients: a pilot study

Intensive Care Medicine Experimental, 2019
Background Septic shock patients exhibit an increased incidence of viral reactivation. Precise timing of such reactivation—as an early marker of immune suppression, or as a consequence of the later—is not known precisely.
François Mallet, Magali Perret, Trang Tran, Boris Meunier, Audrey Guichard, Olivier Tabone, Marine Mommert, Karen Brengel-Pesce, Fabienne Venet, Alexandre Pachot, Guillaume Monneret, Frederic Reynier, Christophe Védrine, Philippe Leissner, Virginie Moucadel, Alain Lepape, Julien Textoris, MIPrea group, REALISM group   +18 more
doaj   +1 more source

Understanding sepsis-induced immunosuppression and organ dysfunctions: from immunosuppression to immunotherapy

Exploration of Immunology, 2022
Sepsis is a life-threatening condition caused by dysregulated host immune response to infection, leading to persistent inflammation followed by immunosuppression.
Dablu Lal Gupta, Tejprakash Sinha, Richa Pathak, Sanjeev Bhoi, D. N. Rao   +4 more
doaj   +1 more source

Macromolecular Immunosuppressants [PDF]

Biotechnology Journal, 2005
AbstractRecombinant immunosuppressants have come of age and represent a significant class of quite diverse drugs. They target extracellular molecules, and either label or inhibit them. Those targets are soluble factors or membrane proteins almost all of which are components of a very complex molecular network of communication and amplification. Notably,
Theo, Dingermann, Ilse, Zündorf
openaire   +2 more sources