Results 21 to 30 of about 51,191 (308)

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study [PDF]

, 2016
There is an increasing interest for monitoring circulating myeloid-derived suppressor cells (MDSCs) in cancer patients, but there are also divergences in their phenotypic definition.
Brandau, Sven, Britten, Cedrik M, Bronte, Vincenzo, Damuzzo, Vera, Gouttefangeas, C\ue9cile, Mandruzzato, Susanna, Maurer, Dominik, Ottensmeier, Christian, van der Burg, Sjoerd H, Walter, Steffen, Welters, Marij J. P   +10 more
core   +2 more sources

Tumor Exosome-Mediated MDSC Activation [PDF]

The American Journal of Pathology, 2011
To the Editor-in-Chief: In a recent issue of The American Journal of Pathology, Xiang et al1 published their results concerning the effects of tumor-derived exosomes on myeloid-derived suppressor cell (MDSC) biology. They compared the biological effects of exosomes derived from in vitro cultured B16 tumor cells (termed C-exo for culture exosome) and
Gregoire Mignot, Fanny Chalmin, Sylvain Ladoire, Cédric Rébé, François Ghiringhelli, Xiaoyu Xiang, Douglas D. Taylor, William Grizzle, Huang-Ge Zhang   +8 more
openaire   +1 more source

MIF: metastasis/MDSC-inducing factor? [PDF]

OncoImmunology, 2013
Myeloid-derived suppressor cells (MDSCs) promote tumor growth and metastasis. We have recently demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhances the immunosuppressive microenvironment by increasing the abundance of monocytic MDSCs within the tumor.
Simpson, Kendra D., Cross, Janet V.
openaire   +2 more sources

Elevated circulating myeloid‐derived suppressor cells associated with poor prognosis in B‐cell non‐Hodgkin's lymphoma patients

Immunity, Inflammation and Disease, 2022
Introduction Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous cell population with the ability to suppress immune responses. MDSCs usually cluster in cancer, inflammation, and autoimmune diseases.
Yangyang Wang, Jiyu Wang, Fengfeng Zhu, Huiping Wang, Liuying Yi, Keke Huang, Zhimin Zhai   +6 more
doaj   +1 more source

Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as ...
Adrian J. Thrasher, Arturo Sala, Chow, Croce, Dale, Daniel A. Morgenstern, Giorgia Santilli, Ikeda, Izabela Piotrowska, John Anderson, Katie Pearson, Marco D'Alicarnasso, Nourredine Himoudi, Olesya Chayka, Sandra Cantilena   +14 more
core   +2 more sources

Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells

Journal for ImmunoTherapy of Cancer, 2023
Background Microphthalmia-associated transcription factor (MITF) is a master regulator of melanogenesis and is mainly expressed in melanoma cells. MITF has also been reported to be expressed in non-pigmented cells, such as osteoclasts, mast cells, and B ...
Yoon Kyung Jeon, Aram Lee, Haesun Park, Soyoung Lim, Jihyun Lim, Jaemoon Koh, Young Yang, Myeong-Sok Lee, Jong-Seok Lim   +8 more
doaj   +1 more source

Tumor-related HSP70 released after cryo-thermal therapy targeted innate immune initiation in the antitumor immune response

International Journal of Hyperthermia, 2020
Purpose In our previous study, a novel cryo-thermal therapy that could stimulate the maturation of innate immune cells to subsequently activate the CD4+Th1 cell-dominated antitumor response was developed.
Jun Zhu, Yue Lou, Ping Liu, Lisa X. Xu
doaj   +1 more source

Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model. [PDF]

, 2017
BackgroundToca 511 (vocimagene amiretrorepvec) is a retroviral replicating vector encoding an optimized yeast cytosine deaminase (CD). Tumor-selective expression of CD converts the prodrug, 5-fluorocytosine (5-FC), into the active chemotherapeutic, 5 ...
Gruber, Harry E, Hiraoka, Kei, Inagaki, Akihito, Jolly, Douglas J, Kasahara, Noriyuki, Kato, Yuki, Lopez Espinoza, Fernando, Mendoza, Daniel, Mitchell, Leah A, Robbins, Joan M   +9 more
core   +1 more source

Potentiating vascular-targeted photodynamic therapy through CSF-1R modulation of myeloid cells in a preclinical model of prostate cancer

OncoImmunology, 2019
Vascular-targeted photodynamic therapy (VTP) induces rapid destruction of targeted tissues and is a promising therapy for prostate cancer. However, the resulting immune response, which may play an important role in either potentiating or blunting the ...
Souhil Lebdai, Mathieu Gigoux, Ricardo Alvim, Alexander Somma, Karan Nagar, Abdel Rahmene Azzouzi, Olivier Cussenot, Taha Merghoub, Jedd D. Wolchok, Avigdor Scherz, Kwanghee Kim, Jonathan Coleman   +11 more
doaj   +1 more source

Swertianolin ameliorates immune dysfunction in sepsis via blocking the immunosuppressive function of myeloid- derived suppressor cells

European Journal of Histochemistry, 2021
In this study, we studied the long-term proliferation trajectory of myeloid-derived suppressor cells (MDSCs) in murine sepsis model and investigated whether swertianolin could modulate the immunosuppressive function of MDSCs.
Zongfang Ren, Haoren Tang, Linjun Wan, Xing Liu, Ning Tang, Lingling Wang, Zhenhui Guo   +6 more
doaj   +1 more source