Results 61 to 70 of about 51,191 (308)

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity [PDF]

, 2016
Various steady state and inflamed tissues have been shown to contain a heterogeneous DC population consisting of developmentally distinct subsets, including cDC1s, cDC2s and monocyte-derived DCs, displaying differential functional specializations.
Bolli, Evangelia, Boon, Louis, De Baetselier, Patrick, Elkrim, Yvon, Geeraerts, Xenia, Guilliams, Martin, Keirsse, Jiri, Kiss, Mate, Lahmar, Qods, Laoui, Damya, Mazzone, Massimiliano, Morias, Yannick, Scott, Charlotte, Serneels, Jens, Sichien, Dorine, Van Ginderachter, Jo A., Van Overmeire, Eva   +16 more
core   +4 more sources

MDSCs in infectious diseases: regulation, roles, and readjustment [PDF]

Cancer Immunology, Immunotherapy, 2018
Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence
Dorhoi, Anca, Glaría, Estibaliz, Garcia-Tellez, Thalia, Nieuwenhuizen, Natalie E, Zelinskyy, Gennadiy, Favier, Benoit, Singh, Anurag, Ehrchen, Jan, Gujer, Cornelia, Münz, Christian, Saraiva, Margarida, Sohrabi, Yahya, Sousa, Ana E, Delputte, Peter, Müller-Trutwin, Michaela, Valledor, Annabel F   +15 more
openaire   +6 more sources

Connections between Metabolism and Epigenetic Modification in MDSCs [PDF]

International Journal of Molecular Sciences, 2020
Myeloid-derived suppressor cells (MDSCs) are major immunosuppressive cells in the tumor microenvironment (TME). During the differentiation and development of MDSCs from myeloid progenitor cells, their functions are also affected by a series of regulatory factors in the TME, such as metabolic reprogramming, epigenetic modification, and cell signaling ...
Haiyan Dai, Huaxi Xu, Shengjun Wang, Jie Ma   +3 more
openaire   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Guadecitabine, in combination with Cyclophosphamide, promotes anti- cancer immunity in BALB/c mice bearing 4T1 mouse mammary carcinoma [PDF]

, 2020
Background: The extremely high mortality rate of patients diagnosed with triple negative breast cancer makes it one of the deadliest forms of cancer. Due to the heterogenous nature of tumors, complete clearance is not achieved and clonal selection occurs
Bear MD, Harry D., Camarena, Carmen, Martin PhD, Rebecca K., Smith, Timothy M.   +3 more
core   +1 more source

Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]

, 2016
Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D., Graham, Laura, Idowu, Michael O., Keim, Rebecca, Manjili, Masoud H., Payne, Kyle K., Toor, Amir A., Wan, Wen, Wang, Xiang-Yang   +8 more
core   +2 more sources

GSH‐Responsive Nanoparticles Enhance Hepatocellular Carcinoma Immunotherapy Through Synergistic Effects of Cuproptosis and PI3K Inhibitor Combination

Advanced Science, EarlyView.
ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu, Jintong Na, Xiyu Liu, Dongsheng Tang, Zhungang Yang, Zheng Cao, Xinyue He, Haihua Xiao, Liping Zhong, Yuan Liao, Yongxiang Zhao   +10 more
wiley   +1 more source

Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system

Food and Agricultural Immunology, 2018
Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing ...
Kexin Zheng, Chenghao Fu, Chunying Jiang, Xiqing Yue, Shiliang Ma   +4 more
doaj   +1 more source

The Generation and Identity of Human Myeloid-Derived Suppressor Cells

Frontiers in Oncology, 2020
Myeloid-derived suppressor cells (MDSCs) are cells of myeloid lineage with a potent immunosuppressive capacity. They are present in cancer patients as well as in patients with severe inflammatory conditions and infections.
Caroline Bergenfelz, Karin Leandersson
doaj   +1 more source

Characterization of Murine Breast Cancer Cell Lines for Anti-Cancer Vaccine [PDF]

, 2017
Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer death among women in the United States (1). While treatments involving radiation and chemotherapy currently exist, disease must be detected early in order
Frazier, Haven N
core   +2 more sources