Results 1 to 10 of about 158,415 (307)

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [PDF]

Nature Communications, 2016
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune ...
Vincenzo Bronte, Sven Brandau, Shu-Hsia Chen, Mario P. Colombo, Alan B. Frey, Tim F. Greten, Susanna Mandruzzato, Peter J. Murray, Augusto Ochoa, Suzanne Ostrand-Rosenberg, Paulo C. Rodriguez, Antonio Sica, Viktor Umansky, Robert H. Vonderheide, Dmitry I. Gabrilovich   +14 more
doaj   +3 more sources

Discovery of Myeloid-Derived Suppressor Cell-Specific Metabolism by Metabolomic and Lipidomic Profiling [PDF]

Metabolites, 2023
The endogenous factors that control the differentiation of myeloid-derived suppressor cells (MDSCs) are not yet fully understood. The purpose of this study was to find MDSC-specific biomolecules through comprehensive metabolomic and lipidomic profiling ...
Jisu Kim, Hwanhui Lee, Hyung-Kyoon Choi, Hyeyoung Min   +3 more
doaj   +2 more sources

Myeloid-derived suppressor cell: A crucial player in autoimmune diseases [PDF]

Frontiers in Immunology, 2022
Myeloid-derived suppressor cells (MDSCs) are identified as a highly heterogeneous group of immature cells derived from bone marrow and play critical immunosuppressive functions in autoimmune diseases.
Dandan Xu, Cheng Li, Yushan Xu, Mingyue Huang, Dawei Cui, Jue Xie   +5 more
doaj   +2 more sources

Modulation of T-cell function by myeloid-derived suppressor cells in hematological malignancies

Frontiers in Cell and Developmental Biology, 2023
Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes that negatively regulate the immune response to cancer and chronic infections.
Vaishali Bhardwaj, Stephen M. Ansell
doaj   +1 more source

"Open Sesame" to the complexity of pattern recognition receptors of myeloid-derived suppressor cells in cancer

Frontiers in Immunology, 2023
Pattern recognition receptors are primitive sensors that arouse a preconfigured immune response to broad stimuli, including nonself pathogen-associated and autologous damage-associated molecular pattern molecules.
Tian Wang, Yushu Hu, Silvia Dusi, Fang Qi, Silvia Sartoris, Stefano Ugel, Francesco De Sanctis   +6 more
doaj   +1 more source

Analysis of the myeloid-derived suppressor cells and annexin A1 in multibacillary leprosy and reactional episodes

BMC Infectious Diseases, 2021
Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Patients have distinct clinical forms, and the host´s immunological response regulate those manifestations.
Stephanni Figueiredo da Silva, Leticia Rossetto da Silva Cavalcante, Ezequiel Angelo Fonseca Junior, Joselina Maria da Silva, José Cabral Lopes, Amilcar Sabino Damazo   +5 more
doaj   +1 more source

Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice. [PDF]

PLoS ONE, 2016
To study the impact of psychosocial stress on the immune system, male mice were subjected to chronic subordinate colony housing (CSC), a preclinically validated mouse model for chronic psychosocial stress.
Dominic Schmidt, Daniel Peterlik, Stefan O Reber, Anja Lechner, Daniela N Männel   +4 more
doaj   +1 more source

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone

Advanced Science, 2022
Atovaquone, an FDA‐approved drug for malaria, is known to inhibit mitochondrial electron transport. A recently synthesized mitochondria‐targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in situ vaccination
Mofei Huang, Donghai Xiong, Jing Pan, Qi Zhang, Yian Wang, Charles R. Myers, Bryon D. Johnson, Micael Hardy, Balaraman Kalyanaraman, Ming You   +9 more
doaj   +1 more source

Role of Polymorphonuclear Myeloid‐Derived Suppressor Cells and Neutrophils in Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Immune cells play a vital role in the pathology of ischemic stroke. Neutrophils and polymorphonuclear myeloid‐derived suppressor cells share a similar phenotype and have attracted increasing attention in immune regulation research, yet their ...
Haomin Yan, Tomohiro Kawano, Hideaki Kanki, Kumiko Nishiyama, Munehisa Shimamura, Hideki Mochizuki, Tsutomu Sasaki   +6 more
doaj   +1 more source

Myeloid Cell Mediated Immune Suppression in Pancreatic CancerSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Pancreatic ductal adenocarcinoma (PDA), the most common pancreatic cancer, is a nearly universally lethal malignancy. PDA is characterized by extensive infiltration of immunosuppressive myeloid cells, including tumor-associated macrophages and myeloid ...
Samantha B. Kemp, Marina Pasca di Magliano, Howard C. Crawford   +2 more
doaj   +1 more source