Results 11 to 20 of about 158,415 (307)

Myeloid-derived suppressor cells in gliomas [PDF]

Contemporary Oncology, 2016
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid progenitors and precursors at different stages of differentiation into granulocytes, macrophages, and dendritic cells.
Anna Gieryng, Bozena Kaminska
doaj   +3 more sources

Myeloid derived suppressor cells [PDF]

OncoImmunology, 2013
The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs).
Waldron, Todd J., Quatromoni, Jon G., Karakasheva, Tatiana A., Singhal, Sunil, Rustgi, Anil K.   +4 more
openaire   +5 more sources

Immunosuppressive effects and mechanisms of three myeloid-derived suppressor cells subsets including monocytic-myeloid-derived suppressor cells, granulocytic-myeloid-derived suppressor cells, and immature-myeloid-derived suppressor cells

Journal of Cancer Research and Therapeutics, 2021
Context: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immune cells of myeloid lineage. Recent reports have suggested that human MDSC are divided into three subsets: monocytic MDSC (M-MDSC), granulocytic MDSC (G-MDSC), and immature MDSC (I-MDSC). However, the characteristics of each human MDSC subset
Yoshiaki, Nagatani, Yohei, Funakoshi, Hirotaka, Suto, Yoshinori, Imamura, Masanori, Toyoda, Naomi, Kiyota, Kimihiro, Yamashita, Hironobu, Minami   +7 more
openaire   +2 more sources

Myeloid-Derived Suppressor Cells [PDF]

Viral Immunology, 2017
AbstractMyeloid cells developed evolutionarily as a major mechanism to protect the host. They evolved as a critical barrier against infections and are important contributors to tissue remodeling. However, in cancer, myeloid cells are largely converted to serve a new master—tumor cells.
openaire   +4 more sources

Distinct myeloid-derived suppressor cell populations in human glioblastoma. [PDF]

Science
Jackson C, Cherry C, Bom S, Dykema AG, Wang R, Thompson E, Zhang M, Li R, Ji Z, Hou W, Zhan W, Zhang H, Choi J, Vaghasia A, Hansen L, Wang W, Bergsneider B, Jones KM, Rodriguez F, Weingart J, Lucas CH, Powell J, Elisseeff J, Yegnasubramanian S, Lim M, Bettegowda C, Ji H, Pardoll D.   +27 more
europepmc   +2 more sources

p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response

Nature Communications, 2023
The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that eventually result in inhibition of the ...
Vincenzo Salemme, Mauro Vedelago, Alessandro Sarcinella, Federico Moietta, Alessio Piccolantonio, Enrico Moiso, Giorgia Centonze, Marta Manco, Andrea Guala, Alessia Lamolinara, Costanza Angelini, Alessandro Morellato, Dora Natalini, Raffaele Calogero, Danny Incarnato, Salvatore Oliviero, Laura Conti, Manuela Iezzi, Daniela Tosoni, Giovanni Bertalot, Stefano Freddi, Francesco A. Tucci, Francesco De Sanctis, Cristina Frusteri, Stefano Ugel, Vincenzo Bronte, Federica Cavallo, Paolo Provero, Marta Gai, Daniela Taverna, Emilia Turco, Salvatore Pece, Paola Defilippi   +32 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells in Sepsis [PDF]

BioMed Research International, 2014
Sepsis is a systemic, deleterious host response to widespread infection. Patients with sepsis will have documented or suspected infection which can progress to a state of septic shock or acute organ dysfunction. Since sepsis is responsible for nearly 3 million cases per year in China and severe sepsis is a common, expensive fatal condition in America ...
Dengming Lai, Chaojin Qin, Qiang Shu
openaire   +2 more sources

Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma

iScience, 2023
Summary: Ependymoma (EPN) is a devastating childhood brain tumor. Single-cell analyses have illustrated the cellular heterogeneity of EPN tumors, identifying multiple neoplastic cell states including a mesenchymal-differentiated subpopulation which ...
Andrea M. Griesinger, Kent Riemondy, Nithyashri Eswaran, Andrew M. Donson, Nicholas Willard, Eric W. Prince, Simon M.L. Paine, Georgia Bowes, John Rheaume, Rebecca J. Chapman, Judith Ramage, Andrew Jackson, Richard G. Grundy, Nicholas K. Foreman, Timothy A. Ritzmann   +14 more
doaj   +1 more source

Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]

, 2016
Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D., Graham, Laura, Idowu, Michael O., Keim, Rebecca, Manjili, Masoud H., Payne, Kyle K., Toor, Amir A., Wan, Wen, Wang, Xiang-Yang   +8 more
core   +2 more sources

Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma [PDF]

, 2015
Background: Immune markers in the peripheral blood of melanoma patients could provide prognostic information. However, there is currently no consensus on which circulating cell types have more clinical impact.
Bachert, Claus, Brochez, Lieve, CHEVOLET, INES, Krysko, Olga, Neyns, Bart, Schreuer, Max, Speeckaert, Reinhart, van Geel, Nanja, Van Gele, Mireille   +8 more
core   +2 more sources