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Positive and negative roles of myeloid cells in cancer immunotherapy [PDF]
Journal for ImmunoTherapy of CancerMyeloid cells are a diverse group of immune cell types with systemic and organ-specific functions. Myeloid cells are frequently found in the tumor microenvironment and their infiltration correlates with survival and response to treatment.
Jaroslav Zak, Judith A Varner
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Harnessing myeloid cells in cancer [PDF]
Molecular CancerCancer-associated myeloid cells due to their plasticity play dual roles in both promoting and inhibiting tumor progression. Myeloid cells with immunosuppressive properties play a critical role in anti-cancer immune regulation.
Su-Yeon Park +7 more
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Targeting the myeloid microenvironment in neuroblastoma
Journal of Experimental & Clinical Cancer Research, 2023 Myeloid cells (granulocytes and monocytes/macrophages) play an important role in neuroblastoma. By inducing a complex immunosuppressive network, myeloid cells pose a challenge for the adaptive immune system to eliminate tumor cells, especially in high ...
Marjolein C. Stip +4 more
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Bv8 mediates myeloid cell migration and enhances malignancy of colorectal cancer
Frontiers in Immunology, 2023 Colorectal cancer (CRC) is the third most predominant malignancy in the world. Although the importance of immune system in cancer development has been well established, the underlying mechanisms remain to be investigated further.
Xiaomeng Li +11 more
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Modulation of T-cell function by myeloid-derived suppressor cells in hematological malignancies
Frontiers in Cell and Developmental Biology, 2023 Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes that negatively regulate the immune response to cancer and chronic infections.
Vaishali Bhardwaj, Stephen M. Ansell
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PLoS ONE, 2022 Dermal wound healing is a complex process which requires the interaction of many cell types and mediators in a highly sophisticated temporal sequence. Myeloid cells which compose of a significant proportion of the inflammatory cells infiltrate to the to ...
Yunyuan Li +3 more
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TGFβ Signaling in Myeloid Cells Promotes Lung and Liver Metastasis Through Different Mechanisms
Frontiers in Oncology, 2021 TGFβ overexpression is commonly detected in cancer patients and correlates with poor prognosis and metastasis. Cancer progression is often associated with an enhanced recruitment of myeloid-derived cells to the tumor microenvironment.
Cristina Stefanescu +6 more
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Molecular Metabolism, 2021 Objective: Immature CD11b + Gr1+ myeloid cells that acquire immunosuppressive capability, also known as myeloid-derived suppressor cells (MDSCs), are a heterogeneous population of cells that regulate immune responses.
Mary P. Udumula +13 more
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Cancer-associated myeloid regulatory cells
Frontiers in Immunology, 2016 Myeloid cells are critically involved in the pathophysiology of cancers. In the tumor microenvironment (TME), they comprise tumor-associated macrophages (TAMs), neutrophils (TANs), dendritic cells and myeloid-derived suppressors cells, which are further ...
Yannick eDe Vlaeminck +3 more
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T cells contribute to tumor progression by favoring pro-tumoral properties of intra-tumoral myeloid cells in a mouse model for spontaneous melanoma. [PDF]
PLoS ONE, 2011 Tumors affect myelopoeisis and induce the expansion of myeloid cells with immunosuppressive activity. In the MT/ret model of spontaneous metastatic melanoma, myeloid cells are the most abundant tumor infiltrating hematopoietic population and their ...
Renée Lengagne +10 more
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