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Positive and negative roles of myeloid cells in cancer immunotherapy [PDF]

Journal for ImmunoTherapy of Cancer
Myeloid cells are a diverse group of immune cell types with systemic and organ-specific functions. Myeloid cells are frequently found in the tumor microenvironment and their infiltration correlates with survival and response to treatment.
Jaroslav Zak, Judith A Varner
doaj   +2 more sources

Harnessing myeloid cells in cancer [PDF]

Molecular Cancer
Cancer-associated myeloid cells due to their plasticity play dual roles in both promoting and inhibiting tumor progression. Myeloid cells with immunosuppressive properties play a critical role in anti-cancer immune regulation.
Su-Yeon Park, Ekaterina Pylaeva, Vikas Bhuria, Adriana Rosa Gambardella, Giovanna Schiavoni, Dimitrios Mougiakakos, Sung-Hoon Kim, Jadwiga Jablonska   +7 more
doaj   +2 more sources

Targeting the myeloid microenvironment in neuroblastoma

Journal of Experimental & Clinical Cancer Research, 2023
Myeloid cells (granulocytes and monocytes/macrophages) play an important role in neuroblastoma. By inducing a complex immunosuppressive network, myeloid cells pose a challenge for the adaptive immune system to eliminate tumor cells, especially in high ...
Marjolein C. Stip, Loes Teeuwen, Miranda P. Dierselhuis, Jeanette H. W. Leusen, Daniëlle Krijgsman   +4 more
doaj   +1 more source

Bv8 mediates myeloid cell migration and enhances malignancy of colorectal cancer

Frontiers in Immunology, 2023
Colorectal cancer (CRC) is the third most predominant malignancy in the world. Although the importance of immune system in cancer development has been well established, the underlying mechanisms remain to be investigated further.
Xiaomeng Li, Enqiang Chang, Enqiang Chang, Jiang Cui, Hailin Zhao, Cong Hu, Kieran P. O’Dea, Nikhil Tirlapur, Gianfranco Balboni, Jiaqiang Zhang, Liming Ying, Daqing Ma   +11 more
doaj   +1 more source

Modulation of T-cell function by myeloid-derived suppressor cells in hematological malignancies

Frontiers in Cell and Developmental Biology, 2023
Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes that negatively regulate the immune response to cancer and chronic infections.
Vaishali Bhardwaj, Stephen M. Ansell
doaj   +1 more source

M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing.

PLoS ONE, 2022
Dermal wound healing is a complex process which requires the interaction of many cell types and mediators in a highly sophisticated temporal sequence. Myeloid cells which compose of a significant proportion of the inflammatory cells infiltrate to the to ...
Yunyuan Li, Hatem Alnojeidi, Ruhangiz T Kilani, Aziz Ghahary   +3 more
doaj   +1 more source

TGFβ Signaling in Myeloid Cells Promotes Lung and Liver Metastasis Through Different Mechanisms

Frontiers in Oncology, 2021
TGFβ overexpression is commonly detected in cancer patients and correlates with poor prognosis and metastasis. Cancer progression is often associated with an enhanced recruitment of myeloid-derived cells to the tumor microenvironment.
Cristina Stefanescu, Merel Van Gogh, Marko Roblek, Marko Roblek, Mathias Heikenwalder, Lubor Borsig, Lubor Borsig   +6 more
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Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism

Molecular Metabolism, 2021
Objective: Immature CD11b + Gr1+ myeloid cells that acquire immunosuppressive capability, also known as myeloid-derived suppressor cells (MDSCs), are a heterogeneous population of cells that regulate immune responses.
Mary P. Udumula, Sharif Sakr, Sajad Dar, Ayesha B. Alvero, Rouba Ali-Fehmi, Eman Abdulfatah, Jing Li, Jun Jiang, Amy Tang, Thomas Buekers, Robert Morris, Adnan Munkarah, Shailendra Giri, Ramandeep Rattan   +13 more
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Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila. [PDF]

, 2012
The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocytes, crystal cells and lamellocytes--
Banerjee, Utpal, Mukherjee, Tina, Shim, Jiwon   +2 more
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HoxA9 binds and represses the Cebpa +8 kb enhancer [PDF]

, 2019
C/EBPα plays a key role in specifying myeloid lineage development. HoxA9 is expressed in myeloid progenitors, with its level diminishing during myeloid maturation, and HOXA9 is over-expressed in a majority of acute myeloid leukemia cases, including those
Aplan, Peter D., Dennison, Lauren, Friedman, Alan D., Guo, Hong, Hess, Jay L., Ma, Peilin, Peng, Lei, Sun, Yuqing   +7 more
core   +2 more sources