Results 21 to 30 of about 5,274,249 (302)

Myeloid Cells in Metastasis [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
Metastatic disease is the leading cause of death in patients with solid cancers. The progression to metastasis is a multistep process that involves detachment of tumor cells from their constraining basement membrane at the primary site, migration and intravasation into the circulation, survival in the circulation, extravasation into the secondary organ,
Agnieszka, Swierczak, Jeffrey W, Pollard
openaire   +2 more sources

Myeloid Derived Suppressor Cells in Chronic Myeloid Leukemia [PDF]

Frontiers in Oncology, 2015
The suppression of the immune system creates a permissive environment for development and progression of cancer. One population of immunosuppressive cells that have become the focus of intense study is myeloid derived suppressor cells (MDSCs), immature myeloid cells able to induce immune-escape, angiogenesis, and tumor progression.
Cesarina eGiallongo, Nunziatina eParrinello, Maria Violetta Brundo, Salvatore Antonino Raccuia, Salvatore Antonino Raccuia, Michelino eDi Rosa, Piera eLa Cava, Tibullo eDaniele   +7 more
openaire   +6 more sources

Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as ...
Chayka, O, Sala, A, Piotrowska, I, Himoudi, N, D'Alicarnasso, M, Cantilena, S, Santilli, G, Morgenstern, DA, Thrasher, AJ, Pearson, K, Anderson, J   +10 more
core   +1 more source

Characterisation of T cell defects in acute myeloid leukaemia [PDF]

, 2009
PhDUnderstanding the immune system in patients with cancer and how it interacts with malignant cells is critical for the development of successful immunotherapeutic strategies at a time when novel cancer treatment approaches are required.
Le Dieu, Helen Rifca
core   +3 more sources

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
E K Allan, Holyoake, T.L., Jorgensen, H.G., A R Craig, T L Holyoake, Allan, E.K., Craig, A.R., H G Jørgensen   +7 more
core   +1 more source

Multi-talented myeloid cells. [PDF]

Discov Immunol
Bankole S, Ng LG, Ginhoux F.
europepmc   +4 more sources

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]

, 2015
Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Sumbayev, Vadim V., Gibbs, Bernhard F, Yasinska, Inna M., Sumbayev, Vadim V, Casely-Hayford, Maxwell A., Gibbs, Bernhard F., Vadim V. Sumbayev, Berger, Steffen M., Maryam Abooali, Prokhorov, Alexandr, Yasinska, Inna M, Abooali, Maryam, Berger, Steffen Michael, Isabel Gonçalves Silva, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Fasler-Kan, Elizaveta, Alexandr Prokhorov, Gonçalves Silva, Isabel, Casely-Hayford, Maxwell A, Maxwell A. Casely-Hayford, Inna M. Yasinska, Steffen M. Berger, Abooali M, Casely-Hayford MA, Berger SM, Yasinska IM, Gibbs BF, Sumbayev VV, Prokhorov A, Gonçalves Silva I, Fasler-Kan E   +31 more
core   +2 more sources

Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells [PDF]

, 2011
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117.
Bernhard F. Gibbs, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Vadim V. Sumbayev, Inna M Yasinska, Abraham E. Oniku, Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Abraham E Oniku, Inna M. Yasinska, Yasinska Inna M., Sumbayev Vadim V., Oniku Abraham E., Gibbs Bernhard F.   +15 more
core   +2 more sources

Junctional adhesion molecule-A is dispensable for myeloid cell recruitment and diversification in the tumor microenvironment

Frontiers in Immunology, 2022
Junctional adhesion molecule-A (JAM-A), expressed on the surface of myeloid cells, is required for extravasation at sites of inflammation and may also modulate myeloid cell activation.
Máté Kiss, Máté Kiss, Máté Kiss, Els Lebegge, Els Lebegge, Aleksandar Murgaski, Aleksandar Murgaski, Aleksandar Murgaski, Helena Van Damme, Helena Van Damme, Daliya Kancheva, Daliya Kancheva, Daliya Kancheva, Jan Brughmans, Jan Brughmans, Isabelle Scheyltjens, Isabelle Scheyltjens, Ali Talebi, Robin Maximilian Awad, Yvon Elkrim, Yvon Elkrim, Pauline M. R. Bardet, Pauline M. R. Bardet, Sana M. Arnouk, Sana M. Arnouk, Cleo Goyvaerts, Johan Swinnen, Frank Aboubakar Nana, Frank Aboubakar Nana, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Damya Laoui, Damya Laoui   +32 more
doaj   +1 more source

A dual origin for Bcr-Abl gene translocation/fusion as dynamics of synergism of the hematopoietic stem cell and hemangioblast in chronic myeloid leukemia [PDF]

, 2015
Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core   +1 more source