Results 21 to 30 of about 396,076 (261)

Junctional adhesion molecule-A is dispensable for myeloid cell recruitment and diversification in the tumor microenvironment

Frontiers in Immunology, 2022
Junctional adhesion molecule-A (JAM-A), expressed on the surface of myeloid cells, is required for extravasation at sites of inflammation and may also modulate myeloid cell activation.
Máté Kiss, Máté Kiss, Máté Kiss, Els Lebegge, Els Lebegge, Aleksandar Murgaski, Aleksandar Murgaski, Aleksandar Murgaski, Helena Van Damme, Helena Van Damme, Daliya Kancheva, Daliya Kancheva, Daliya Kancheva, Jan Brughmans, Jan Brughmans, Isabelle Scheyltjens, Isabelle Scheyltjens, Ali Talebi, Robin Maximilian Awad, Yvon Elkrim, Yvon Elkrim, Pauline M. R. Bardet, Pauline M. R. Bardet, Sana M. Arnouk, Sana M. Arnouk, Cleo Goyvaerts, Johan Swinnen, Frank Aboubakar Nana, Frank Aboubakar Nana, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Damya Laoui, Damya Laoui   +32 more
doaj   +1 more source

Myeloid-derived suppressor cells and their role in gynecological malignancies

Tumor Biology, 2018
Myeloid-derived suppressor cells are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity (they block the proliferation and activity of both T cells and natural killer cells).
Seiji Mabuchi, Eriko Yokoi, Naoko Komura, Tadashi Kimura   +3 more
doaj   +1 more source

Myeloid Cells in Asthma

Microbiology Spectrum, 2017
ABSTRACTAsthma is a heterogeneous chronic inflammatory disorder of the airways, and not surprisingly, many myeloid cells play a crucial role in pathogenesis. Antigen-presenting dendritic cells are the first to recognize the allergens, pollutants, and viruses that are implicated in asthma pathogenesis, and subsequently initiate the adaptive immune ...
Bart N, Lambrecht, Emma K, Persson, Hamida, Hammad   +2 more
openaire   +2 more sources

Epigenetic Regulation of Myeloid Cells [PDF]

Microbiology Spectrum, 2016
ABSTRACT Epigenetic regulation in myeloid cells is crucial for cell differentiation and activation in response to developmental and environmental cues. Epigenetic control involves posttranslational modification of DNA or chromatin, and is also coupled to upstream signaling pathways and transcription factors.
Lionel B, Ivashkiv, Sung Ho, Park
openaire   +2 more sources

Therapeutic Approaches Targeting the Natural Killer-Myeloid Cell Axis in the Tumor Microenvironment

Frontiers in Immunology, 2021
Immunotherapy has transformed cancer treatment by promoting durable clinical responses in a proportion of patients; however, treatment still fails in many patients. Innate immune cells play a key role in the response to immunotherapy.
Larissa S. Carnevalli, Hormas Ghadially, Simon T. Barry   +2 more
doaj   +1 more source

Heterogeneous Myeloid Cells in Tumors [PDF]

Cancers, 2021
Accumulating studies highlight a critical role of myeloid cells in cancer biology and therapy. The myeloid cells constitute the major components of tumor microenvironment (TME). The most studied tumor-associated myeloid cells (TAMCs) include monocytes, tumor-associated macrophages (TAMs), dendritic cells (DCs), cancer-related circulating neutrophils ...
Aixia Dou, Jing Fang
openaire   +2 more sources

Naturally selected CD7 CAR-T therapy without genetic editing demonstrates significant antitumour efficacy against relapsed and refractory acute myeloid leukaemia (R/R-AML)

Journal of Translational Medicine, 2022
Background The survival rate for patients with relapsed and refractory acute myeloid leukaemia (R/R-AML) remains poor, and treatment is challenging.
Yu Lu, Ying Liu, Shupeng Wen, Na Kuang, Xuejun Zhang, Jianqiang Li, Fuxu Wang   +6 more
doaj   +1 more source

Circadian metabolism in myeloid cells. [PDF]

Life Metab
Abstract Circadian rhythms are fundamental regulators of physiological processes, including immune function. Recent insights uncover that not only lymphocytes but also myeloid cells possess intrinsic circadian clocks that govern their behavior and function.
Xu Y, Wang C, Ho PC.
europepmc   +4 more sources

Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature. [PDF]

PLoS ONE, 2017
Resident tissue myeloid cells play a role in many aspects of physiology including development of the vascular systems. In the blood vasculature, myeloid cells use VEGFC to promote angiogenesis and can use Wnt ligands to control vascular branching and to ...
Ajit Muley, Yoshi Odaka, Ian P Lewkowich, Shruti Vemaraju, Terry P Yamaguchi, Carrie Shawber, Belinda H Dickie, Richard A Lang   +7 more
doaj   +1 more source

Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression

Frontiers in Immunology, 2018
Tumor cells frequently produce soluble factors that favor myelopoiesis and recruitment of myeloid cells to the tumor microenvironment (TME). Consequently, the TME of many cancer types is characterized by high infiltration of monocytes, macrophages ...
Robin Maximilian Awad, Yannick De Vlaeminck, Johannes Maebe, Cleo Goyvaerts, Karine Breckpot   +4 more
doaj   +1 more source