Results 11 to 20 of about 5,274,249 (302)
Characteristics of Tip-DCs and MDSCs and their potential role in leishmaniasis [PDF]
Frontiers in Microbiology, 2012 Since the first description of dendritic cells (DCs) by Ralph Marvin Steinman and Zanvil Alexander Cohn in 1973, the myeloid lineage of leukocytes was investigated intensively.
Maximilian eSchmid +2 more
doaj +2 more sources
Myeloid-derived suppressor cells in gliomas
Contemporary Oncology, 2016 Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid progenitors and precursors at different stages of differentiation into granulocytes, macrophages, and dendritic cells.
Anna Gieryng, Bozena Kaminska
doaj +2 more sources
Harnessing myeloid cells in cancer
Molecular CancerCancer-associated myeloid cells due to their plasticity play dual roles in both promoting and inhibiting tumor progression. Myeloid cells with immunosuppressive properties play a critical role in anti-cancer immune regulation.
Su-Yeon Park +7 more
doaj +3 more sources
Engineering IL-4 resistant proinflammatory human myeloid cells for cancer immunotherapy. [PDF]
Mol OncolWe developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Barberi T, Friedman AD.
europepmc +2 more sources
Ontogeny of Myeloid Cells [PDF]
Frontiers in Immunology, 2014 Granulocytes, monocytes, macrophages, and dendritic cells (DCs) represent a subgroup of leukocytes, collectively called myeloid cells. During the embryonic development of mammalians, myelopoiesis occurs in a stepwise fashion that begins in the yolk sac and ends up in the bone marrow (BM).
Ismé eDe Kleer +4 more
openaire +6 more sources
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity [PDF]
Nature Reviews Immunology, 2021 Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They are implicated in the regulation of immune responses in many pathological conditions and are closely associated with poor clinical outcomes in cancer.
Veglia, Filippo +2 more
openaire +2 more sources
Myeloid Cells in Glioblastoma Microenvironment [PDF]
Cells, 2020 Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is notoriously resistant to immunotherapy mainly due to its unique immune microenvironment. High dimensional data analysis reveals the extensive heterogeneity of immune components making up the GBM microenvironment.
Alessandra De Leo +2 more
openaire +4 more sources
Myeloid Cells and Lymphangiogenesis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2012 The lymphatic vascular system and the hematopoietic system are intimately connected in ontogeny and in physiology. During embryonic development, mammalian species derive a first lymphatic vascular plexus from the previously formed anterior cardinal vein, whereas birds and amphibians have a lymphatic vascular system of dual origin, composed of lymphatic
Zumsteg, Adrian, Christofori, Gerhard
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Evolution of Myeloid Cells [PDF]
Microbiology Spectrum, 2016 ABSTRACTIn 1882, Elie Metchnikoff identified myeloid-like cells from starfish larvae responding to the invasion by a foreign body (rose thorn). This marked the origins for the study of innate immunity, and an appreciation that cellular immunity was well established even in these “primitive” organisms. This chapter focuses on these myeloid cells as well
Daniel R, Barreda +2 more
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The mechanics of myeloid cells
Biology of the Cell, 2020 AbstractThe effects of cell size, shape and deformability on cellular function have long been a topic of interest. Recently, mechanical phenotyping technologies capable of analysing large numbers of cells in real time have become available. This has important implications for biology and medicine, especially haemato‐oncology and immunology, as immune ...
Bashant, Kathleen R +7 more
openaire +6 more sources