Results 41 to 50 of about 5,274,249 (302)

Therapeutic Approaches Targeting the Natural Killer-Myeloid Cell Axis in the Tumor Microenvironment

Frontiers in Immunology, 2021
Immunotherapy has transformed cancer treatment by promoting durable clinical responses in a proportion of patients; however, treatment still fails in many patients. Innate immune cells play a key role in the response to immunotherapy.
Larissa S. Carnevalli, Hormas Ghadially, Simon T. Barry   +2 more
doaj   +1 more source

Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice. [PDF]

PLoS ONE, 2016
To study the impact of psychosocial stress on the immune system, male mice were subjected to chronic subordinate colony housing (CSC), a preclinically validated mouse model for chronic psychosocial stress.
Dominic Schmidt, Daniel Peterlik, Stefan O Reber, Anja Lechner, Daniela N Männel   +4 more
doaj   +1 more source

Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression

Frontiers in Immunology, 2018
Tumor cells frequently produce soluble factors that favor myelopoiesis and recruitment of myeloid cells to the tumor microenvironment (TME). Consequently, the TME of many cancer types is characterized by high infiltration of monocytes, macrophages ...
Robin Maximilian Awad, Yannick De Vlaeminck, Johannes Maebe, Cleo Goyvaerts, Karine Breckpot   +4 more
doaj   +1 more source

Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation [PDF]

, 2012
The mitochondrial respiratory chain (MRC) consists of protein complexes I, II, III, IV and V that support oxidative phosphorylation (OXPHOS), which depends on electron transport to generate adenosine triphosphate (ATP).
Flis, Krzysztof, Skorski, Tomasz, Bhatia, Ravi, Irvine, David, Bhatia, R., Copland, Mhairi, Irvine, D., Copland, M., Skorski, T., Flis, K.   +9 more
core   +1 more source

Infiltrating myeloid cell diversity determines oncological characteristics and clinical outcomes in breast cancer

Breast Cancer Research, 2023
Background Breast cancer presents as one of the top health threats to women around the world. Myeloid cells are the most abundant cells and the major immune coordinator in breast cancer tumor microenvironment (TME), target therapies that harness the anti-
Chenxuan Yang, Jiaxiang Liu, Shuangtao Zhao, Qingyao Shang, Fei Ren, Kexin Feng, Ruixuan Zhang, Xiyu Kang, Xin Wang, Xiang Wang   +9 more
doaj   +1 more source

Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy

Frontiers in Cell and Developmental Biology, 2021
Tumor-infiltrating myeloid cells are a prominent pro-tumorigenic immune cell population that limit host anti-tumor immunity and present a significant obstacle for many cancer immunotherapies.
Jianying Li, Chelsea Bolyard, Gang Xin, Gang Xin, Zihai Li, Zihai Li   +5 more
doaj   +1 more source

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia [PDF]

, 2012
MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. Here we show that the knockdown of MECOM (E) and MECOM (ME) isoforms reduces cell division at low cell density, inhibits colony-forming cells by 34% and moderately ...
Jørgensen, Heather G., Holyoake, T.L., Holyoake, T., Abed El Baky, Mohamed, Bartholomew, C., Melo, Junia V., Roy, P., Melo, J.V., Abed El Baky, M., Roy, S., Jørgensen, H., Jorgensen, H.G., Strathdee, G., Strathdee, Gordon, Melo, J., Roy, Swagata, Holyoake, Tessa L., Roy, Poornima, Bartholomew, Christopher   +18 more
core   +1 more source

Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer

OncoImmunology, 2017
The colorectal tumor microenvironment contains a diverse population of myeloid cells that are recruited and converted to immunosuppressive cells, thus facilitating tumor escape from immunoediting.
Xiaowei Chen, Yoshihiro Takemoto, Huan Deng, Moritz Middelhoff, Richard A. Friedman, Timothy H. Chu, Michael J. Churchill, Yan Ma, Karan K. Nagar, Yagnesh H. Tailor, Siddhartha Mukherjee, Timothy C. Wang   +11 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells in Some Oncohematological Diseases

Клиническая онкогематология, 2017
Myeloid-derived suppressor cells are immature myeloid cells with immunosuppressive properties. The review presents characteristics of myeloid-derived suppressor cells.
Aleksandr Vasil’evich Ponomarev
doaj   +1 more source

Differentiation and Characterization of Myeloid Cells [PDF]

Current Protocols in Immunology, 2014
AbstractEx vivo differentiation of myeloid cells begins with an enriched population of bone marrow–derived hematopoietic stem cells generated by lineage depletion and/or positive selection for CD34+ antigen (human) or Sca‐1+ (mouse) cells, which are then expanded and subsequently induced in vitro in a process that recapitulates normal myeloid ...
Dipti, Gupta, Hetavi Parag, Shah, Krishnakumar, Malu, Nancy, Berliner, Peter, Gaines   +4 more
openaire   +2 more sources