Results 41 to 50 of about 633,166 (162)
CellsPD-1 (Programmed cell death protein 1) regulates the metabolic reprogramming of myeloid-derived suppressor cells and myeloid cell differentiation, as well as the type I interferon (IFN-I) signaling pathway in myeloid cells in the tumor microenvironment ...
Liyan Liang +7 more
doaj +1 more source
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [PDF]
, 2016 Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune ...
Brandau, Sven +14 more
core +2 more sources
Peripherally derived myeloid cells induce disease-dependent phenotypic changes in microglia
Frontiers in Cellular Neuroscience, 2023 In central nervous system (CNS) injury and disease, peripherally derived myeloid cells infiltrate the CNS parenchyma and interact with resident cells, propagating the neuroinflammatory response.
Estrid Thougaard +10 more
doaj +1 more source
Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia [PDF]
, 2014 Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although mechanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecules contributing to malignant expansion and ...
Bilban, Martin +15 more
core +1 more source
Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice
eLife, 2017 Dedifferentiation of acini to duct-like cells occurs during the physiologic damage response in the pancreas, but this process can be co-opted by oncogenic Kras to drive carcinogenesis.
Yaqing Zhang +8 more
doaj +1 more source
Early endothelial progenitor cells as a source of myeloid cells to improve the pre-vascularisation of bone constructs [PDF]
European Cells & Materials, 2014 According to present knowledge, blood derived endothelial progenitor cells (EPC) might act as proangiogenic myeloid cells, which play a fundamental role in the regulation of angiogenesis and blood vessel reorganisation. In this context, we have evaluated
Y Shi +6 more
doaj +1 more source
The Role of Myeloid Cells in GBM Immunosuppression
Frontiers in Immunology, 2022 Gliomas are intrinsic brain tumors that originate from glial cells. Glioblastoma (GBM) is the most aggressive glioma type and resistant to immunotherapy, mainly due to its unique immune environment.
Ya-Jui Lin +5 more
doaj +1 more source
Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs [PDF]
, 2014 The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions.
Manjili, Masoud H.
core +1 more source
Blood Neoplasia: T-cell acute lymphoblastic leukemia (T-ALL) is a common pediatric malignancy, and central nervous system (CNS) involvement is associated with inferior prognoses.
Ryan S. Humphrey +3 more
doaj +1 more source
Optic nerve as a source of activated retinal microglia post-injury
Acta Neuropathologica Communications, 2018 Using mice expressing green fluorescent protein (GFP) from a transgenic CD11c promoter we found that a controlled optic nerve crush (ONC) injury attracted GFPhi retinal myeloid cells to the dying retinal ganglion cells and their axons.
Neal D. Heuss +6 more
doaj +1 more source