Results 31 to 40 of about 633,166 (162)

Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression

Frontiers in Immunology, 2018
Tumor cells frequently produce soluble factors that favor myelopoiesis and recruitment of myeloid cells to the tumor microenvironment (TME). Consequently, the TME of many cancer types is characterized by high infiltration of monocytes, macrophages ...
Robin Maximilian Awad, Yannick De Vlaeminck, Johannes Maebe, Cleo Goyvaerts, Karine Breckpot   +4 more
doaj   +1 more source

Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML [PDF]

, 2002
HTIF1α, a transcription coactivator which is able to mediate RARα activity and functionally interact with PML, is encoded by a gene on chromosome 7q32–34, which is a critical region in acute myeloid leukemias (AML). With the assumption that this gene may
AGUIARI, Gianluca, CASTOLDI, GL, CUNEO, Antonio, DE ANGELI, C, DEL SENNO, Laura, GANDINI, D, LANZA, F, MANZATI, E, PANDOLFI, PP   +8 more
core   +1 more source

Characteristics of Tip-DCs and MDSCs and their potential role in leishmaniasis

Frontiers in Microbiology, 2012
Since the first description of dendritic cells (DCs) by Ralph Marvin Steinman and Zanvil Alexander Cohn in 1973, the myeloid lineage of leukocytes was investigated intensively.
Maximilian eSchmid, Anja Kathrin Wege, Uwe eRitter   +2 more
doaj   +1 more source

Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy

Frontiers in Cell and Developmental Biology, 2021
Tumor-infiltrating myeloid cells are a prominent pro-tumorigenic immune cell population that limit host anti-tumor immunity and present a significant obstacle for many cancer immunotherapies.
Jianying Li, Chelsea Bolyard, Gang Xin, Gang Xin, Zihai Li, Zihai Li   +5 more
doaj   +1 more source

Radiation-induced myeloid leukemia in murine models. [PDF]

, 2014
The use of radiation therapy is a cornerstone of modern cancer treatment. The number of patients that undergo radiation as a part of their therapy regimen is only increasing every year, but this does not come without cost.
Davoren, Michael, Rivina, Leena, Schiestl, Robert H   +2 more
core   +2 more sources

Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer

OncoImmunology, 2017
The colorectal tumor microenvironment contains a diverse population of myeloid cells that are recruited and converted to immunosuppressive cells, thus facilitating tumor escape from immunoediting.
Xiaowei Chen, Yoshihiro Takemoto, Huan Deng, Moritz Middelhoff, Richard A. Friedman, Timothy H. Chu, Michael J. Churchill, Yan Ma, Karan K. Nagar, Yagnesh H. Tailor, Siddhartha Mukherjee, Timothy C. Wang   +11 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells in Some Oncohematological Diseases

Клиническая онкогематология, 2017
Myeloid-derived suppressor cells are immature myeloid cells with immunosuppressive properties. The review presents characteristics of myeloid-derived suppressor cells.
Aleksandr Vasil’evich Ponomarev
doaj   +1 more source

Infiltrating myeloid cell diversity determines oncological characteristics and clinical outcomes in breast cancer

Breast Cancer Research, 2023
Background Breast cancer presents as one of the top health threats to women around the world. Myeloid cells are the most abundant cells and the major immune coordinator in breast cancer tumor microenvironment (TME), target therapies that harness the anti-
Chenxuan Yang, Jiaxiang Liu, Shuangtao Zhao, Qingyao Shang, Fei Ren, Kexin Feng, Ruixuan Zhang, Xiyu Kang, Xin Wang, Xiang Wang   +9 more
doaj   +1 more source

Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells In Vivo [PDF]

, 2018
Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells.
Keppler, SJ, Pakalniškytė, D, Papaioannou, NE, Pasztoi, M, Rambichler, S, Reis E Sousa, C, Rogers, NC, Salvermoser, J, Schraml, BU, Straub, T, Van Blijswijk, J   +10 more
core   +1 more source

Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as ...
Adrian J. Thrasher, Arturo Sala, Chow, Croce, Dale, Daniel A. Morgenstern, Giorgia Santilli, Ikeda, Izabela Piotrowska, John Anderson, Katie Pearson, Marco D'Alicarnasso, Nourredine Himoudi, Olesya Chayka, Sandra Cantilena   +14 more
core   +2 more sources