Results 61 to 70 of about 4,880,233 (300)

Myeloid Cells in Traffic [PDF]

Journal of Innate Immunity, 2013
such as circadian changes [4] but also under inflammatory conditions where disturbance of these axes induces increases in circulating myeloid cells and worsening of inflammatory diseases [5, 6] . The molecular mechanisms underlying the control of neutrophil homeostasis in steady-state and inflammatory conditions are reviewed in detail by Strydom and ...
openaire   +3 more sources

Early endothelial progenitor cells as a source of myeloid cells to improve the pre-vascularisation of bone constructs [PDF]

European Cells & Materials, 2014
According to present knowledge, blood derived endothelial progenitor cells (EPC) might act as proangiogenic myeloid cells, which play a fundamental role in the regulation of angiogenesis and blood vessel reorganisation. In this context, we have evaluated
Y Shi, G Kramer, A Schröder, CJ Kirkpatrick, A Seekamp, H Schmidt, S Fuchs   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice

eLife, 2017
Dedifferentiation of acini to duct-like cells occurs during the physiologic damage response in the pancreas, but this process can be co-opted by oncogenic Kras to drive carcinogenesis.
Yaqing Zhang, Wei Yan, Esha Mathew, Kevin T Kane, Arthur Brannon III, Maeva Adoumie, Alekya Vinta, Howard C Crawford, Marina Pasca di Magliano   +8 more
doaj   +1 more source

Peripherally derived myeloid cells induce disease-dependent phenotypic changes in microglia

Frontiers in Cellular Neuroscience, 2023
In central nervous system (CNS) injury and disease, peripherally derived myeloid cells infiltrate the CNS parenchyma and interact with resident cells, propagating the neuroinflammatory response.
Estrid Thougaard, Estrid Thougaard, Brianna Carney, Agnieszka Wlodarczyk, Agnieszka Wlodarczyk, Roberta Brambilla, Roberta Brambilla, Roberta Brambilla, Kate Lykke Lambertsen, Kate Lykke Lambertsen, Kate Lykke Lambertsen   +10 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia [PDF]

, 2012
MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. Here we show that the knockdown of MECOM (E) and MECOM (ME) isoforms reduces cell division at low cell density, inhibits colony-forming cells by 34% and moderately ...
Jørgensen, Heather G., Holyoake, T.L., Holyoake, T., Abed El Baky, Mohamed, Bartholomew, C., Melo, Junia V., Roy, P., Melo, J.V., Abed El Baky, M., Roy, S., Jørgensen, H., Jorgensen, H.G., Strathdee, G., Strathdee, Gordon, Melo, J., Roy, Swagata, Holyoake, Tessa L., Roy, Poornima, Bartholomew, Christopher   +18 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Tumor-associated myeloid cells support murine T-ALL in the central nervous system via integrin signaling

Blood Neoplasia
: T-cell acute lymphoblastic leukemia (T-ALL) is a common pediatric malignancy, and central nervous system (CNS) involvement is associated with inferior prognoses.
Ryan S. Humphrey, Seohee Nam, Dennis C. Wylie, Lauren I. R. Ehrlich   +3 more
doaj   +1 more source

The Role of Myeloid Cells in GBM Immunosuppression

Frontiers in Immunology, 2022
Gliomas are intrinsic brain tumors that originate from glial cells. Glioblastoma (GBM) is the most aggressive glioma type and resistant to immunotherapy, mainly due to its unique immune environment.
Ya-Jui Lin, Ya-Jui Lin, Caren Yu-Ju Wu, Caren Yu-Ju Wu, Janet Yuling Wu, Michael Lim   +5 more
doaj   +1 more source