Results 71 to 80 of about 396,076 (261)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Regulatory Myeloid Cells in Transplantation [PDF]

Transplantation, 2014
Regulatory myeloid cells (RMC) are emerging as novel targets for immunosuppressive (IS) agents and hold considerable promise as cellular therapeutic agents. Herein, we discuss the ability of regulatory macrophages, regulatory dendritic cells, and myeloid-derived suppressor cells to regulate alloimmunity, their potential as cellular therapeutic agents ...
Brian R, Rosborough, Dàlia, Raïch-Regué, Heth R, Turnquist, Angus W, Thomson   +3 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Tracking Monocytes and Macrophages in Tumors With Live Imaging

Frontiers in Immunology, 2019
In most cancers, myeloid cells represent the major component of the immune microenvironment. Deciphering the impact of these cells on tumor growth and in response to various anti-tumor therapies is a key issue.
Marie Laviron, Christophe Combadière, Alexandre Boissonnas   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Testing the Role of Myeloid Cell Glucose Flux in Inflammation and Atherosclerosis

Cell Reports, 2014
Summary: Inflammatory activation of myeloid cells is accompanied by increased glycolysis, which is required for the surge in cytokine production. Although in vitro studies suggest that increased macrophage glucose metabolism is sufficient for cytokine ...
Tomohiro Nishizawa, Jenny E. Kanter, Farah Kramer, Shelley Barnhart, Xia Shen, Anuradha Vivekanandan-Giri, Valerie Z. Wall, Jason Kowitz, Sridevi Devaraj, Kevin D. O’Brien, Subramaniam Pennathur, Jingjing Tang, Robert S. Miyaoka, Elaine W. Raines, Karin E. Bornfeldt   +14 more
doaj   +1 more source

Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy

Journal of Hematology & Oncology, 2022
Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-ligand 1, and cytotoxic T-lymphocyte-associated protein 4 provide deep and durable treatment responses which have revolutionized oncology.
Yi Wang, Kai Conrad Cecil Johnson, Margaret E. Gatti-Mays, Zihai Li   +3 more
doaj   +1 more source

Myeloid cells in cardiovascular organs [PDF]

Journal of Internal Medicine, 2018
AbstractMyeloid cells assume a wide range of phenotypes, some of which are protective against injury and infection whilst others promote cardiovascular disease. This heterogeneity is partially caused by switching of cell sources from local tissue‐resident macrophage proliferation to recruitment of circulating cells, and partially due to macrophages ...
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Role of Tumor-Associated Myeloid Cells in Modulating Cancer Therapy

Frontiers in Oncology, 2020
Myeloid cells include various cellular subtypes that are distinguished into mononuclear and polymorphonuclear cells, derived from either common myeloid progenitor cells (CMPs) or myeloid stem cells.
Christiana M. Neophytou, Christiana M. Neophytou, Chryso Pierides, Maria-Ioanna Christodoulou, Paul Costeas, Paul Costeas, Theodora-Christina Kyriakou, Panagiotis Papageorgis, Panagiotis Papageorgis   +8 more
doaj   +1 more source