Results 71 to 80 of about 633,166 (162)

The Role of Tumor-Associated Myeloid Cells in Modulating Cancer Therapy

Frontiers in Oncology, 2020
Myeloid cells include various cellular subtypes that are distinguished into mononuclear and polymorphonuclear cells, derived from either common myeloid progenitor cells (CMPs) or myeloid stem cells.
Christiana M. Neophytou, Christiana M. Neophytou, Chryso Pierides, Maria-Ioanna Christodoulou, Paul Costeas, Paul Costeas, Theodora-Christina Kyriakou, Panagiotis Papageorgis, Panagiotis Papageorgis   +8 more
doaj   +1 more source

Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia

Haematologica, 2010
Background C-type lectin-like molecule-1 is a transmembrane receptor expressed on myeloid cells, acute myeloid leukemia blasts and leukemic stem cells.
Xiaoxian Zhao, Shweta Singh, Cecile Pardoux, Jingsong Zhao, Eric D. Hsi, Arie Abo, Wouter Korver   +6 more
doaj   +1 more source

Tumor angiogenic switch determines sustained proliferative malignant transformation in tumorigenesis and overlaps with para-inflammatory phenomena [PDF]

, 2015
Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core  

Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia [PDF]

, 2015
Approximately 20% of patients with acute myeloid leukaemia (AML) have a mutation in FMS-like-tyrosine-kinase-3 (FLT3). FLT3 is a trans-membrane receptor with a tyrosine kinase domain which, when activated, initiates a cascade of phosphorylated proteins ...
A Puissant, AJ Mohamed, BD Smith, BJ Druker, C Chung, C Dos Santos, C Thiede, C Venkataraman, CC Smith, CK Hahn, F Heidel, F Honda, G Juliusson, H Kiyoi, HS Ma, J Adolfsson, JA Dubovsky, JA Dubovsky, JA Woyach, JA Woyach, JB Petro, K Fiedler, KU Birkenkamp, L Zaitseva, M Levis, M Nakao, ML Wang, N Feldhahn, NJ Horwood, PP Zarrinkar, Q Xu, RF Schlenk, RM Stone, S Knapper, S Meshinchi, SA Ezell, SA Rushworth, SA Rushworth, SA Rushworth, SA Rushworth, T Kindler, T Matsunaga, T Oellerich, T-l Gu, V Vijayan, W Gao, Y Alvarado, Y Baba, Y Yamamoto, Y-T Tai   +49 more
core   +2 more sources

Beyond the immune suppression: the immunotherapy in prostate cancer [PDF]

, 2015
Prostate cancer (PCa) is the second most common cancer in men.Aswell in many other human cancers, inflammation and immune suppression have an important role in their development.We briefly describe the host components that interact with the tumor to ...
Agliano', Anna Maria, Cattarino, Susanna, Collalti, Giulia, Sciarra, Alessandro, Silvestri, Ida   +4 more
core   +3 more sources

Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers. [PDF]

, 2012
Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previously had been detected in the mature ...
Guo, W, Hayes, R, Hubbard, A, Ji, Z, Lan, Q, Li, G, Linet, M, McHale, C, Rappaport, S, Rothman, N, Shen, M, Smith, Martyn T., Vermeulen, R, Yin, S, Zhang, L   +14 more
core   +1 more source

Clinical Implication of Targeting of Cancer Stem Cells [PDF]

, 2012
The existence of cancer stem cells (CSCs) is receiving increasing interest particularly due to its potential ability to enter clinical routine. Rapid advances in the CSC field have provided evidence for the development of more reliable anticancer ...
Al-Hajj M, Bao S, Bardsley MR, Barlogie B, Bentzen SM, Bertout JA, Blazek ER, Bruns CJ, Brunsvig PF, C.J. Bruns, Cao X, Chen MS, Clayton S, Collins AT, Cortes J, Costello R, Dalerba P, Diehn M, Dou J, Dylla SJ, Eyler CE, Fischer S, Garvalov BK, Ghiaur G, Gibbs CP, Gilbert CA, H. Niess, Haferlach T, Hochhaus A, Hosen N, Huff CA, Hurwitz H, Jiang X, Jones RJ, Jones RJ, Jones RJ, Ju Z, K.-W. Jauch, Kanamori M, Kiladjian JJ, Klonisch T, Kojima T, Korpal M, L. Zhao, Li C, Liu G, Liu R, Liu S, Lonardo E, Mauro MJ, McDermott SP, Merante S, Mimeault M, Moserle L, O’Brien SG, Park CY, Phillips TM, Platet N, Q. Bao, Rasheed ZA, Reya T, Reya T, Richardson GD, Roeder I, Seidel S, Singh A, Singh SK, Strojnik T, Stupp R, Suh MR, Szotek PP, Tang C, Tang M, Todaro M, Tu LC, Vermeulen L, Wilson BJ, Wright MH, Xu N, Y. Zhao, Yu F, Zhao C, Zhou BB   +82 more
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Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
A Quintas-Cardama, A Quintas-Cardama, A Quintas-Cardama, AJ Tipping, AJ Tipping, B Zhang, C Akgul, C Bellodi, G Gurel, H de Lavallade, H Konig, HG Jorgensen, HM Kantarjian, J Kuroda, KJ Aichberger, L Legros, M Copland, M Copland, NB Heaney, R Chen, R Tang, RG Powell, RM Stone, S Chu, SM Graham, SV Sharma, T Kobayashi, Y Chen   +27 more
core   +1 more source

Hierarchy in Gene Expression is Predictive for Adult Acute Myeloid Leukemia

, 2015
Cancer progresses with a change in the structure of the gene network in normal cells. We define a measure of organizational hierarchy in gene networks of affected cells in adult acute myeloid leukemia (AML) patients.
Deem, Michael W., Tripathi, Shubham
core   +1 more source

Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells [PDF]

, 2018
Acute inflammation is a complex and tightly regulated homeostatic process that includes leukocyte migration from the vasculature into tissues to eliminate the pathogen/injury, followed by a pro-resolving response promoting tissue repair.
Achuthan, Alivernini, Alivernini, Alvaro-Gracia, Anderson, Asquith, Bamboat, Behrens, Bell, Ben Nasr, Benham, Black, Bluml, Brentano, Burmester, Burmester, Burmester, Catrina, Cauli, Cheung, Chu, Chu, Couzin-Frankel, Cramer, Cross, den Berg, den Brand, Dillon, Donlin, Ehrenstein, Elmesmari, Ferraccioli, Field, Firestein, Frank-Bertoncelj, Gao, Ginhoux, Greven, Guiducci, Guo, Hambleton, Hamilton, Haschka, Herenius, Hogg, Hurst, Iliev, James, Jongbloed, Kaplanski, Kokkonen, Kollias, Konig, Kriegler, Kurowska-Stolarska, Kurowska-Stolarska, Kurowska-Stolarska, Lemke, Malmstrom, Mann, McInnes, McInnes, McInnes, McLoughlin, Midwood, Miller, Misharin, Misso, Moret, Moret, Morton, Murata, Na, Nagy, Nassar, Ng, O'Connell, O'Connell, O'Keeffe, Ohshima, Okada, Paolino, Park, Rajasekhar, Ramwadhdoebe, Rauber, Reynolds, Roberts, Rothlin, Rupaimoole, Rycke, Sacre, Schett, Singh, Smith, Smith, Smolen, Sokolove, Stanczyk, Steidl, Takeuchi, Tannahill, Thai, Tsoumakidou, Udalova, Vandenabeele, Villani, Watts, Weinblatt, Weiss, Williamson, Wolf, Xiong, Yeo, Yu, Zou   +115 more
core   +1 more source