Results 71 to 80 of about 5,274,249 (302)

Regulatory immune cells in transplantation. [PDF]

, 2012
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured ...
Bushell, Andrew, Wood, Kathryn J, Andrew Bushell, Joanna Hester, Kathryn J. Wood, Hester, Joanna   +5 more
core   +1 more source

Tumor-associated macrophages, dendritic cells, and neutrophils: biological roles, crosstalk, and therapeutic relevance

Medical Review, 2021
Tumor-associated myeloid cells constitute a series of plastic and heterogeneous cell populations within the tumor microenvironment (TME), and exhibit different phenotypes and functions in response to various microenvironmental signals.
Shen Mingyi, Du Yanhua, Ye Youqiong
doaj   +1 more source

The Role of Myeloid Cells in GBM Immunosuppression

Frontiers in Immunology, 2022
Gliomas are intrinsic brain tumors that originate from glial cells. Glioblastoma (GBM) is the most aggressive glioma type and resistant to immunotherapy, mainly due to its unique immune environment.
Ya-Jui Lin, Ya-Jui Lin, Caren Yu-Ju Wu, Caren Yu-Ju Wu, Janet Yuling Wu, Michael Lim   +5 more
doaj   +1 more source

Mechanobiology of myeloid cells

Current Opinion in Cell Biology
Tissue-resident myeloid cells sense and transduce mechanical signals such as stiffness, stretch and compression. In the past two years, our understanding of the mechanosensitive signalling pathways in myeloid cells has significantly expanded. Moreover, it is increasingly clear which mechanical signals induce myeloid cells towards a pro- or anti ...
Janssen, Eline, van den Dries, Koen, Ventre, Maurizio, Cambi, Alessandra   +3 more
openaire   +4 more sources

Myeloid IκBα deficiency promotes atherogenesis by enhancing leukocyte recruitment to the plaques. [PDF]

, 2011
Activation of the transcription factor NF-κB appears to be involved in different stages of atherogenesis. In this paper we investigate the role of NF-κB inhibitor IκBα in atherosclerosis.
Menno P J de Winther, Hofker Marten H., Hofker, Marten H., Rupec Rudolf A., Curfs Danielle M. J., Woezik, J.H.G. (Johannes H.) van, Hoeksema, Marten A., Goossens, P. (Pieter), Rudolf A Rupec, Hoeksema Marten A., Leenen, Pieter J. M., Leenen, P.J.M. (Pieter), Winther, M.P.J. (Menno P.) de, Marion J. J. Gijbels, Leenen Pieter J. M., Hoeksema, M.A. (Marten), Danielle M J Curfs, Pieter J M Leenen, Marten A. Hoeksema, Gijbels, Marion J. J., Vergouwe, Monique N., Gijbels, M. (Marion), Johannes H. G. van Woezik, Rupec, R.A. (Rudolf), Xanthouleas, Sofia, de Winther, Menno P. J., Gijbels Marion J. J., Monique N. Vergouwe, Xanthoulea Sofia, Goossens, Pieter, Curfs, Danielle M. J., Johannes H G van Woezik, Marten H. Hofker, van Woezik, Johannes H. G., Marion J J Gijbels, Xanthoulea, Sofia, Vergouwe, Y. (Yvonne), Xanthoulea, S. (Sofia), van Woezik Johannes H. G., Sofia Xanthoulea, Goossens Pieter, Vergouwe Monique N., Rupec, Rudolf A., Hofker, M.A. (Marten), Curfs, D.M.J. (Danielle M.), Marten A Hoeksema, Marten H Hofker, Pieter J. M. Leenen, Menno P. J. de Winther, Danielle M. J. Curfs, de Winther Menno P. J., Rudolf A. Rupec, Pieter Goossens, Monique N Vergouwe, Hofker, MH, Curfs, DMJ, Rupec, RA, van Woezik, JHG, Vergouwe, MN, Gijbels, MJJ, de Winther, MPJ, Goossens, P, Xanthoulea, S, Hoeksema, MA, Leenen, Pieter   +64 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Positive and negative roles of myeloid cells in cancer immunotherapy

Journal for ImmunoTherapy of Cancer
Myeloid cells are a diverse group of immune cell types with systemic and organ-specific functions. Myeloid cells are frequently found in the tumor microenvironment and their infiltration correlates with survival and response to treatment.
Jaroslav Zak, Judith A Varner
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Comparison of Myeloid Cells in Circulation and in the Tumor Microenvironment of Patients with Colorectal and Breast Cancers

Journal of Immunology Research, 2017
We have previously reported levels of myeloid cells in the periphery and in the tumor microenvironment (TME) of patients with primary breast cancer (PBC) and colorectal cancer (CRC).
Salman M. Toor, Eyad Elkord
doaj   +1 more source

S100A9 Derived From Myeloma Associated Myeloid Cells Promotes TNFSF13B/TNFRSF13B-Dependent Proliferation and Survival of Myeloma Cells

Frontiers in Oncology, 2021
Multiple myeloma (MM) is a lethal hematological malignancy characterized by abundant myeloid cells in the microenvironment that fuel tumor progression. But the mechanism by which myeloid cells support myeloma cells has not been fully explored.
Lingzhang Meng, Lingzhang Meng, Qiang Tang, Jingjie Zhao, Zechen Wang, Liuzhi Wei, Liuzhi Wei, Qiuju Wei, Qiuju Wei, Lianfei Yin, Shiguan Luo, Jian Song, Jian Song   +12 more
doaj   +1 more source