Results 81 to 90 of about 633,166 (162)

Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption

Nature Communications
Interactions between osteolineage cells and myeloid cells play important roles in maintaining skeletal homeostasis. Herein, we find that osteolineage cells transfer mitochondria to myeloid cells.
Peng Ding, Chuan Gao, Jian Zhou, Jialun Mei, Gan Li, Delin Liu, Hao Li, Peng Liao, Meng Yao, Bingqi Wang, Yafei Lu, Xiaoyuan Peng, Chenyi Jiang, Jimin Yin, Yigang Huang, Minghao Zheng, Youshui Gao, Changqing Zhang, Junjie Gao   +18 more
doaj   +1 more source

Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis

Haematologica, 2010
Background Residual chronic myeloid leukemia disease following imatinib treatment has been attributed to the presence of quiescent leukemic stem cells intrinsically resistant to imatinib.
Fabrizio Vianello, Federica Villanova, Veronica Tisato, Stefania Lymperi, Ka-Kei Ho, Ana R. Gomes, David Marin, Dominique Bonnet, Jane Apperley, Eric W.-F. Lam, Francesco Dazzi   +10 more
doaj   +1 more source

Granulocytic myeloid-derived suppressor cells increased in early phases of primary HIV infection depending on TRAIL plasma level [PDF]

, 2017
Background It has been demonstrated that Myeloid Derived Suppressor Cells (MDSC) are expanded in HIV-1 infected individuals and correlated with disease progression.
Abbate, Isabella, Agrati, Chiara, Ammassari, Adriana, Antinori, Andrea, BILOTTA, MARIA TERESA, Bordoni, Veronica, CAPOBIANCHI, Maria Rosaria, Casetti, Rita, Cimini, Eleonora, Martini, Federico, Pinnetti, Carmela, Sacchi, Alessandra, Tumino, Nicola, Turchi, Federica   +13 more
core   +1 more source

The interleukin-3 receptor CD123 targeted SL-401 mediates potent cytotoxic activity against CD34+CD123+ cells from acute myeloid leukemia/myelodysplastic syndrome patients and healthy donors

Haematologica, 2018
Diseases with clonal hematopoiesis such as myelodysplastic syndrome and acute myeloid leukemia have high rates of relapse. Only a small subset of acute myeloid leukemia patients are cured with chemotherapy alone. Relapse in these diseases occurs at least
Rajeswaran Mani, Swagata Goswami, Bhavani Gopalakrishnan, Rahul Ramaswamy, Ronni Wasmuth, Minh Tran, Xiaokui Mo, Amber Gordon, Donna Bucci, David M. Lucas, Alice Mims, Christopher Brooks, Adrienne Dorrance, Alison Walker, William Blum, John C. Byrd, Gerard Lozanski, Sumithira Vasu, Natarajan Muthusamy   +18 more
doaj   +1 more source

Expression quantitative trait loci are highly sensitive to cellular differentiation state [PDF]

, 2009
Blood cell development from multipotent hematopoietic stem cells to specialized blood cells is accompanied by drastic changes in gene expression for which the triggers remain mostly unknown.
A Gerrits, Albertina Ausema, Alice Gerrits, AR Whiteley, B Wang, Bert Dontje, Bruno M. Tesson, D Bryder, E Petretto, EC Forsberg, EE Schadt, EE Schadt, EJ Chesler, EJ Chesler, Ellen Weersing, G Dennis Jr, Gerald de Haan, Greg Gibson, HH Goring, J Wang, JD Storey, JJ Keurentjes, JL Peirce, JY Wu, KH Wang, L Bystrykh, Leonid V. Bystrykh, M Morley, MA West, MJ Anderson, MJ Kiel, MV Rockman, N Hubner, NB Ivanova, R Alberts, R Breitling, Rainer Breitling, RC Jansen, Ritsert C. Jansen, SA Monks, SM Chambers, V Emilsson, Xusheng Wang, Y Chen, Y Katoh, Y Li, Y Li, Y Liang, Yang Li   +48 more
core   +8 more sources

Targeting myeloid cells for hematological malignancies: the present and future

Biomarker Research
Hematological malignancies are a diverse group of cancers that originate in the blood and bone marrow and are characterized by the abnormal proliferation and differentiation of hematopoietic cells.
Zihui Guan, Zhengqi Zhang, Kaiyan Wang, Shukai Qiao, Teng Ma, Lina Wu   +5 more
doaj   +1 more source

Misfolded N-CoR is linked to the ectopic reactivation of CD34/Flt3-based stem-cell phenotype in promyelocytic and monocytic acute myeloid leukemia

Frontiers in Oncology, 2015
Nuclear receptor co-repressor (N-CoR) is the key component of generic co-repressor complex essential for the transcriptional control of genes involved in cellular hemostasis.
Dawn Sijin Nin, Li eFeng, Sridevi eVisvanathan, Matiullah eKhan   +3 more
doaj   +1 more source

Molecular mechanisms in haematological malignancies [PDF]

, 2009
Haematopoiesis requires the constant production of large numbers of peripheral blood cells. This process is under tight control of transcription factor networks as well as cytokines, growth factors and hormones.
Avellino, Roberto, Grech, Godfrey, Schembri-Wismayer, Pierre   +2 more
core  

Stability and Bifurcation of the Immune Model of Chronic Myeloid Leukemia with Time Delay

Journal of Harbin University of Science and Technology
In order to investigate the effects of the differentiation delay in chronic myeloid leukemia stem cells on the dynamic behaviors among chronic myeloid leukemia stem cells, chronic myeloid leukemia mature cells and effector T cells, a delayed immune ...
WANG Jingnan, SUN Yue
doaj   +1 more source

Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions

Journal of Neuroinflammation
Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular debris and regulating inflammation. These cells are activated in several blinding ischemic retinal diseases including diabetic retinopathy ...
Rami A. Shahror, Carol A. Morris, Aya A. Mohammed, Melissa Wild, Bushra Zaman, Christian D. Mitchell, Paul H. Phillips, Nancy J. Rusch, Esraa Shosha, Abdelrahman Y. Fouda   +9 more
doaj   +1 more source