Results 41 to 50 of about 7,249,751 (246)
Murine gammaherpesvirus-68 expands, but does not activate, CD11b+ gr-1+ splenocytes in vivo
Journal of Inflammation, 2012 Background Murine gammaherpesvirus 68 (HV-68) is an efficient pathogen, capable of infecting and establishing lifelong latency in rodents. While many studies have demonstrated the ability of this viral infection to modulate immune responses, a unifying ...
Nelson Daniel A +3 more
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Myeloid-derived suppressor cells in Chronic myeloid leukemia
Frontiers in Oncology, 2015 The suppression of the immune system create a permissive environment for development and progression of cancer. One population of immunosuppressive cells that have become the focus of intense study is myeloid derived suppressor cells (MDSCs), immature ...
Cesarina eGiallongo +7 more
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Cell Death and Disease, 2022 Tumors modify myeloid cell differentiation and induce an immunosuppressive microenvironment. Granulocytic myeloid-derived suppressor cells (G-MDSCs), the main subgroup of myeloid-derived suppressor cells (MDSCs), are immature myeloid cells (IMCs) with ...
Yingying Sun +9 more
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Targeting myeloid-derived suppressor cells for cancer therapy
Cancer Biology & Medicine, 2021 The emergence and clinical application of immunotherapy is considered a promising breakthrough in cancer treatment. According to the literature, immune checkpoint blockade (ICB) has achieved positive clinical responses in different cancer types, although
Hongchao Tang, Hao Li, Zhijun Sun
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Myeloid‐derived suppressor cells in malignant melanoma [PDF]
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2014 SummaryMelanoma is known for its rapid progression, metastasis to distant organs and therapeutic resistance. Despite high melanoma immunogenicity, the results of immunotherapeutic clinical studies are mostly unsatisfactory. One explanation is the development of strong immunosuppression mediated by highly immunosuppressive regulatory leukocytes, in ...
Viktor, Umansky +3 more
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The contribution of bone marrow-derived cells to angiogenesis and lymphangiogenesis in murine models of carcinogenesis [PDF]
, 2009 Cancer is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via ...
Zumsteg, Adrian
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Role of myeloid-derived suppressor cells in hormone-dependent cancers
, 2021 Tumour-infiltrating myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid cells. The main feature of MDSCs is their ability to suppress T-cell activation and function, which leads to immunosuppressive activity in the tumour ...
Angela R. Elia +2 more
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Myeloid-Derived Suppressor Cells in Trypanosoma cruzi Infection
Frontiers in Cellular and Infection Microbiology, 2021 Myeloid-derived suppressor cells (MDSCs) are immature heterogeneous myeloid cells that expand in pathologic conditions as cancer, trauma, and infection.
Manuel Fresno +3 more
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Polarization and reprogramming of myeloid-derived suppressor cells [PDF]
Journal of Molecular Cell Biology, 2013 Myeloid-derived suppressor cells (MDSC) have recently emerged as one of the central regulators of the immune system. In recent years, interest in understanding MDSC biology and applying MDSC for therapeutic purpose has exploded exponentially. Despite recent progress in MDSC biology, the mechanisms underlying MDSC development from expansion and ...
Wen-Chin, Yang +3 more
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In Vitro 3D Staphylococcus aureus Abscess Communities Induce Bone Marrow Cells to Expand into Myeloid-Derived Suppressor Cells [PDF]
, 2021 Staphylococcus aureus is the main causative pathogen of subcutaneous, bone, and implant-related infections, forming structures known as staphylococcal abscess communities (SACs) within tissues that also contain immunosuppressive myeloid-derived ...
T. Fintan Moriarty +15 more
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