Results 61 to 70 of about 162,344 (302)
Myeloid-derived suppressor cells and vaccination against pathogens
Frontiers in Cellular and Infection Microbiology, 2022 It is widely accepted that the immune system includes molecular and cellular components that play a role in regulating and suppressing the effector immune response in almost any process in which the immune system is involved.
Estefanía Prochetto +4 more
doaj +1 more source
Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs [PDF]
, 2014 The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions.
Manjili, Masoud H.
core +1 more source
Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice [PDF]
, 2012 The use of conventional cytotoxic agents at metronomic schedules, alone or in combination with targeted agents or immunotherapy, is being explored as a promising anticancer strategy.
Alaniz, Laura Daniela +9 more
core +1 more source
Myeloid derived suppressor cells in human diseases [PDF]
International Immunopharmacology, 2011 Myeloid derived suppressor cells (MDSC) have been described as a heterogeneous cell population with potent immune suppressor function in mice. Limited data are available on MDSC in human diseases. Interpretation of these data is complicated by the fact that different markers have been used to analyze human MDSC subtypes in various clinical settings ...
Tim F, Greten +2 more
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Journal of Nanobiotechnology, 2020 Background Myeloid derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) are two of the major players involved in the inhibition of anti-tumor immune response in cancer patients, leading to poor prognosis.
Laura Pinton +12 more
doaj +1 more source
Targeting Myeloid-Derived Suppressor Cells in Ovarian Cancer
Cells, 2021 Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity. They also directly stimulate tumor cell proliferation, metastasis, and angiogenesis.
Seiji Mabuchi +2 more
doaj +1 more source
In Brief: Myeloid-derived suppressor cells in cancer [PDF]
, 2017 The role of myeloid-derived suppressor cells (MDSCs) in cancer development has become clear over recent years, and MDSC targeting is an emerging opportunity for enhancing the effectiveness of current anticancer therapies.
Bronte +8 more
core +1 more source
EBioMedicine, 2020 Mycobacterium tuberculosis (M.tb) is likely the most successful human pathogen, capable of evading protective host immune responses and driving metabolic changes to support its own survival and growth.
Leigh A. Kotzé +7 more
doaj +1 more source