Results 81 to 90 of about 7,249,751 (246)

Related CCR Translation from CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

, 2011
Related CCR Translation from CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing ...
Helen Bauer (14981735), Philipp Bittner (13573382), Daniel Nörenberg (14981738), Georg Wedekind (14981741), Christine Zoglmeier (14981732), Nadja Sandholzer (2133463), Stefan Endres (384040), Moritz Rapp (14920814), Carole Bourquin (826230), David Anz (653655)   +9 more
core   +1 more source

Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells

Clinics, 2014
OBJECTIVE: It has been shown that SOCS-1 plays an important role in the proper control of cytokine/growth factor responses and acts as a tumor suppressor in acute myeloid leukemias.
Veronica Tisato, Alessia Norcio, Claudio Celeghini, Daniela Milani, Arianna Gonelli, Paola Secchiero   +5 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Monocyte-Derived Suppressor Cells in Transplantation

, 2015
Myeloid-derived suppressor cells (MDSC) are cells of myeloid origin with enhanced suppressive function. They are negative regulators of the immune responses and comprise a heterogeneous mixture of immunosuppressive cells of monocytic (M-MDSC) and ...
Ochando, Jordi, Bronte, Vincenzo, Jordi Ochando, Patricia Conde, Conde, Patricia, Vincenzo Bronte   +5 more
core   +1 more source

Phenotypical Characterization and Isolation of Tumor-Derived Mouse Myeloid-Derived Suppressor Cells

, 2021
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population composed of mature and immature cells of myeloid origin that play a major role in tumor progression by inhibiting the antitumor immune responses mediated by T cells.
Bronte V, Musiu C, Ugel S, Barouni RM, Canè S.   +4 more
core   +1 more source

Early Expansion of Monocytic Myeloid-Derived Suppressor Cells Predicts Survival in Sepsis and Is Possibly Associated With Activation of Endoplasmic Reticulum Stress Pathways

Frontiers in Bioscience-Landmark
Background:Sepsis is characterized by profound immune dysregulation, in which myeloid-derived suppressor cells (MDSCs) serve as key regulators of the host immune response.
Juanli Liu, Tana Wuren, Xiaoyan Song, Xue Sun, Siqing Ma, Rili Ge   +5 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Allies or Enemies—The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment

Frontiers in Immunology, 2019
For decades, cancer was considered a disease driven by genetic mutations in tumor cells, therefore afflicting a single cell type. This simplified view was slowly replaced by the understanding that interactions between malignant cells and neighboring ...
Lisa Haas, Anna C. Obenauf
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection [PDF]

, 2012
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other ...
Jianbin Xiang, Xiaodong Gu, Yan Wang, Zongyou Chen   +3 more
core   +1 more source