Results 91 to 100 of about 7,249,751 (246)

Induction of myelodysplasia by myeloid-derived suppressor cells [PDF]

Journal of Clinical Investigation, 2013
Myelodysplastic syndromes (MDS) are age-dependent stem cell malignancies that share biological features of activated adaptive immune response and ineffective hematopoiesis. Here we report that myeloid-derived suppressor cells (MDSC), which are classically linked to immunosuppression, inflammation, and cancer, were markedly expanded in the bone marrow ...
Chen, X., Eksioglu, E.A., Zhou, J, Zhang, L., Djeu, J., Fortenbery, N., Epling-Burnette, P., Van Bijnen, S., Dolstra, H., Dolstra, H., Cannon, J., Youn, J.I., Donatelli, S.S., Qin, D., de Witte, T.J., de Witte, T.J., Tao, J., Wang, Huaquan, Cheng, P., Gabrilovich, D.I., List, A., Wei, S.   +21 more
openaire   +4 more sources

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Supplementary Figure from Caspase-1 from Human Myeloid-Derived Suppressor Cells Can Promote T Cell–Independent Tumor Proliferation

, 2018
Supplementary Figure from Caspase-1 from Human Myeloid-Derived Suppressor Cells Can Promote T Cell–Independent Tumor ...
Peter J. Murray (9250913), Michael Korrer (14078547), Drew Pardoll (558107), Qi Zeng (221318), David L. Masica (2469427), Mikhail Gorbounov (8209239), Young J. Kim (9717833), Juan Fu (441822)   +7 more
core   +1 more source

A dual origin for Bcr-Abl gene translocation/fusion as dynamics of synergism of the hematopoietic stem cell and hemangioblast in chronic myeloid leukemia [PDF]

, 2015
Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core   +1 more source

Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence

, 2022
Supplementary Data from Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma ...
T.L. Shirley Chiu (14962085), Chung-Mau Lo (14962091), Oscar W.H. Yeung (14962058), Hui Liu (14962064), Li Pang (14962055), Xinxiang Yang (14962073), Wenqi Qiu (14962079), Kevin T.P. Ng (14962061), Jiang Liu (14962070), Zhiwei Chen (14962088), Jiye Zhu (14962067), Tao Ding (14962076), Kwan Man (14950386), Yuewen Wang (14962082)   +13 more
core   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

MicroRNA-20b promotes the accumulation of CD11b+Ly6G+Ly6C low myeloid-derived suppressor cells in asthmatic mice

, 2017
miR-20b is a member of the miR-106a-363 gene cluster, which has been shown to play an important role in a variety of diseases, including cancer, inflammation, and autoimmune diseases.
Jing He, Helong Wang, Jie Tang, Hua Ma, Yimeng Wang, Shujun Guo, Yulan Luo, Lin Shen, Chuanwang Song   +8 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Characterisation of the role of KLF5 in normal haemopoiesis and acute myeloid leukaemia. [PDF]

, 2011
Krüppel-like factor 5 (KLF5) encodes a zinc finger transcription factor involved in growth, differentiation and apoptosis of a number of different tissues, and it has previously been implicated as either a tumour suppressor or oncogene in various solid ...
Diakiw, Sonya
core