Results 111 to 120 of about 7,249,751 (246)
Myeloid-derived suppressor cells, age and cancer [PDF]
OncoImmunology, 2013 We have recently discovered that the levels of circulating myeloid-derived suppressor cells, which are associated with an impaired T-cell proliferation and produce high amounts of reactive oxygen species, increase with age and are elevated in individuals in remission from cancer.
openaire +2 more sources
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Myeloid-derived suppressor cells in cancer
, 2008 Myeloid-derived suppressor cells in ...
Bronte, Vincenzo, Serafini P.
core
Advanced Science, EarlyView.Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang +8 more
wiley +1 more source
, 2019 Li-Chun Lu,1–3 Chun-Jung Chang,1,2 Chih-Hung Hsu1–31Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan; 2Departments of Oncology, National Taiwan University Hospital, Taipei, Taiwan; 3Department of ...
Chang CJ, Lu LC, Hsu CH
core
Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer [PDF]
, 2015 Development of solid cancer depends on escape from host immunosurveillance. Various types of immune cells contribute to tumor-induced immune suppression, including tumor associated macrophages, regulatory T cells, type 2 NKT cells, and myeloid-derived ...
Hiroshi Katoh, Masahiko Watanabe
core +1 more source
Monocytic Myeloid-Derived Suppressor Cells in Chronic Infections
Frontiers in Immunology, 2018 Heterogeneous populations of myeloid regulatory cells (MRC), including monocytes, macrophages, dendritic cells, and neutrophils, are found in cancer and infectious diseases.
Anca Dorhoi +3 more
doaj +1 more source
Plasticity of myeloid-derived suppressor cells in cancer
Current Opinion in Immunology, 2018 In recent years, myeloid-derived suppressor cells (MDSC) have emerged as one of the major inhibitors of immune effector cell function in cancer. MDSC represent a heterogeneous population of largely immature myeloid cells that are characterized by a pathological state of activation and display potent immune suppressive activity.
Evgenii, Tcyganov +3 more
openaire +3 more sources
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment
Journal of Hematology & Oncology, 2019 Plenty of immune cells infiltrate into the tumor microenvironment (TME) during tumor progression, in which myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells with immunosuppressive activity.
Xinyu Tian +4 more
doaj +1 more source