Results 41 to 50 of about 5,642,725 (257)

A Transcriptomic Severity Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients

Critical Care Explorations, 2021
OBJECTIVES:. Clinically deployable methods for the rapid and accurate prediction of sepsis severity that could elicit a meaningful change in clinical practice are currently lacking.
Scott C. Brakenridge, MD, Petr Starostik, MD, Gabriella Ghita, PhD, Uros Midic, PhD, Dijoia Darden, MD, Brittany Fenner, MD, James Wacker, MS, Philip A. Efron, MD, Oliver Liesenfeld, MD, Timothy E. Sweeney, MD, PhD, Lyle L. Moldawer, PhD   +10 more
doaj   +1 more source

Adrenal Insufficiency in Prolonged Critical Illness

, 2011
INTRODUCTION: Adrenal insufficiency is common in critically ill patients and affects their prognosis, but little is known about how adrenal function changes during prolonged critical illness.
WU, JENN-YU;HSU, SZU-CHUN;KU, SHIH-CHI;HO, CHAO-CHI;YU, CHONG-JEN;YANG, PAN-CHYR, 巫震宇;徐思淳;古世基;何肇基;余忠仁;楊泮池   +1 more
core   +1 more source

Critical Illness Myopathy: Glucocorticoids revisited? [PDF]

, 2019
Over the past decades, survival rates of critical illness have constantly increased. As a consequence, the incidences of important complications of intensive care unit (ICU) treatment become more and more prevalent.
Schefold, Joerg C., Z'Graggen, Werner J., Z'Graggen WJ, Schefold JC   +3 more
core   +2 more sources

Defining Pediatric Chronic Critical Illness: A Scoping Review.

, 2022
20.500.12530/87857Children with chronic critical illness (CCI) are hypothesized to be a high-risk patient population with persistent multiple organ dysfunction and functional morbidities resulting in recurrent or prolonged critical care; however, it is ...
Cayouette, Florence, Sandarage, Ryan, International Pediatric Chronic Critical Illness Collaborative and Members of the International Pediatric Chronic Critical Illness Collaborative:, Kazzaz, Yasser M, McNally, James Dayre, Yee, Belinda, Welten, Alexandra, Smith, Hazel A, Zorko, David J, Lasso, Ruben, Junior, José Colleti, Brooke, Peter, Lee, Laurie A, Ames, Stefanie G, O'Hearn, Katie, Members of the International Pediatric Chronic Critical Illness Collaborative:, International Pediatric Chronic Critical Illness Collaborative, Choong, Karen, Jayawarden, Supun Kotteduwa, O'Mahony, Aoife, Rochwerg, Bram, Chow, Cristelle, Pinto, Neethi, Heneghan, Julia A, Rodríguez-Rubio, Miguel, Perry, Mallory A, Killien, Elizabeth Y, Almazyad, Mohammed A, Francoeur, Conall   +28 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Innate immune training in the neonatal response to sepsis

Molecular Medicine
Neonates, especially those born prematurely, are highly vulnerable to infection-induced mortality. Numerous observational and immunological studies in newborns have shown that live attenuated vaccines have beneficial, non-specific effects (NSEs) against ...
Jaimar C. Rincon, Dayuan Wang, Valerie E. Polcz, Evan L. Barrios, Marvin L. Dirain, Ricardo F. Ungaro, Dina C. Nacionales, Leilani Zeumer-Spataro, Feifei Xiao, Philip A. Efron, Lyle L. Moldawer, Guoshuai Cai, Shawn D. Larson   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Risk factors for bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation: a systematic review and meta-analysis

BMC Pulmonary Medicine
Background Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a late-onset complication that significantly impairs patients’ quality of life and is associated with a high mortality rate.
Guangchen Pu, Guangmin Nong, Qing Wei, Yunyan He, Wenguang Jia, Zhenhao Lu, Guosheng Qiu, Jun Xie, Xun Chen   +8 more
doaj   +1 more source

Dealing with missing delirium assessments in prospective clinical studies of the critically ill: a simulation study and reanalysis of two delirium studies

BMC Medical Research Methodology, 2021
Background In longitudinal critical care studies, researchers may be interested in summarizing an exposure over time and evaluating its association with a long-term outcome. For example, the number of days a patient has delirium (i.e., brain dysfunction)
Rameela Raman, Wencong Chen, Michael O. Harhay, Jennifer L. Thompson, E. Wesley Ely, Pratik P. Pandharipande, Mayur B. Patel   +6 more
doaj   +1 more source