Results 51 to 60 of about 583,528 (304)

Decoding lung-kidney interactions in sepsis: an integrated view of molecular mechanisms, pathophysiology, and therapeutic interventions

Frontiers in Immunology
Sepsis, a great health concern globally, is characterized by multi-organ dysfunction and high mortality rate. As highly vascularized organs, the kidney and lung are the most susceptible in sepsis.
Chenye Ma, Hongyi Li, Zirong Chen, Heng Song, Yuze Wang, Zhihui Liu, Xuefan Bu, Xianfei Ding, Hanfang Si, Jinghua Yang, Tongwen Sun   +10 more
doaj   +1 more source

DENTAL SEPSIS [PDF]

BMJ, 1914
n ...
openaire   +4 more sources

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Gasdermins in sepsis

Frontiers in Immunology, 2023
Sepsis is a hyper-heterogeneous syndrome in which the systemic inflammatory response persists throughout the course of the disease and the inflammatory and immune responses are dynamically altered at different pathogenic stages. Gasdermins (GSDMs) proteins are pore-forming executors in the membrane, subsequently mediating the release of pro ...
Wenhua Wang, Zhihui He, Zhihui He
openaire   +3 more sources

Major sepsis study confirms back to basics approach [PDF]

, 2014
In 2001 Rivers et al. published a landmark study in the New England Journal of Medicine showing that in a single centre, involving patients presenting to an emergency department with severe sepsis and septic shock, an early goal-directed therapy (EGDT ...
Nathwani, D.
core   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Preterm birth skews the developmental trajectory of myeloid-derived suppressor cells in the first 48 hours of life: single-cell transcriptomics and inferred intercellular communication

Molecular Medicine
Background Prematurity is a leading cause of neonatal and childhood mortality, with infections driving early deaths. Innate immunity provides frontline defense after birth and is shaped in part by myeloid-derived suppressor cells (MDSCs).
Miguel Hernández-Ríos, Jaimar Rincon, Leandro Balzano-Nogueira, Valerie Polcz, Dayuan Wang, Whitman Wiggins, Christine Rodhouse, Athina Yoham, Feifei Xiao, Ricardo Ungaro, Marvin Dirain, Lyle Moldawer, Robert Maile, Guoshuai Cai, Philip Efron, Shawn Larson   +15 more
doaj   +1 more source

Presepsin is a novel highly effective sepsis marker (Review)

Сучасні медичні технології, 2020
In this review the most effective markers of septic process like Procalcitonin, C-reactive protein, and cytokines compared to the new marker – Presepsin (PSP) are analyzed.
S. D. Shapoval, I. L. Savon, L. V. Vasylevska, M. M. Sofilkanych   +3 more
doaj   +1 more source

Leukocyte Activation Profile Assessed by Raman Spectroscopy Helps Diagnosing Infection and Sepsis

Critical Care Explorations, 2021
Objectives:. Leukocytes are first responders to infection. Their activation state can reveal information about specific host immune response and identify dysregulation in sepsis.
Anuradha Ramoji, PhD, Daniel Thomas-Rüddel, MD, Oleg Ryabchykov, PhD, Michael Bauer, MD, Natalie Arend, MSc, Evangelos J. Giamarellos-Bourboulis, MD, Jesper Eugen-Olsen, PhD, Michael Kiehntopf, MD, Thomas Bocklitz, PhD, Jürgen Popp, PhD, Frank Bloos, MD, PhD, Ute Neugebauer, PhD   +11 more
doaj   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source