Results 51 to 60 of about 895,147 (354)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
BMC Infectious DiseasesObjectives This study aims to examine changes in incidence and mortality in Staphylococcus aureus bacteraemia (SAB) over time and between sexes, describe clinical characteristics and asses their associations with 30-day mortality. Methods We included 837
Ingvild Haugan +11 more
doaj +1 more source
A snapshot of compliance with the sepsis six care bundle in two acute hospitals in the West Midlands, UK [PDF]
, 2019 The sepsis six care bundle has been adopted by hospitals in England and Wales for the management of patients with sepsis, with the aim of increasing survival when all elements of the bundle are achieved.
Frankling, Catriona +6 more
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Molecular MedicineT cell memory significantly alters the immune response and organ dysfunction induced by the murine cecal ligation and puncture (CLP) model of sepsis.
Matthew D. Taylor +9 more
doaj +1 more source
Frontiers in ImmunologySepsis, a great health concern globally, is characterized by multi-organ dysfunction and high mortality rate. As highly vascularized organs, the kidney and lung are the most susceptible in sepsis.
Chenye Ma +10 more
doaj +1 more source
Association of Chorioamnionitis with Aberrant Neonatal Gut Colonization and Adverse Clinical Outcomes. [PDF]
, 2016 ObjectiveChorioamnionitis (inflammation of the placenta and fetal membranes) and abnormal gastrointestinal colonization have been associated with an increased risk of sepsis and death in preterm infants, but whether chorioamnionitis causes abnormal ...
Ambalavanan, Namasivayam +5 more
core +1 more source
Frontiers in Immunology, 2023 Sepsis is a hyper-heterogeneous syndrome in which the systemic inflammatory response persists throughout the course of the disease and the inflammatory and immune responses are dynamically altered at different pathogenic stages. Gasdermins (GSDMs) proteins are pore-forming executors in the membrane, subsequently mediating the release of pro ...
Wenhua Wang, Zhihui He, Zhihui He
openaire +3 more sources
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source