Results 61 to 70 of about 782,437 (306)

Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis

The Scientific World Journal, 2014
Neonatal sepsis (NS) is an important cause of mortality in newborns and life-threatening disorder in infants. The meta-analysis was performed to investigate the diagnosis value of tumor necrosis factor-α (TNF-α) test in NS.
Bokun Lv, Jie Huang, Haining Yuan, Wenying Yan, Guang Hu, Jian Wang   +5 more
doaj   +1 more source

Impact of neonatal intensive care bed configuration on rates of late-onset bacterial sepsis and methicillin-resistant Staphylococcus aureus colonization [PDF]

, 2015
OBJECTIVES: Infections cause significant morbidity and mortality in neonatal intensive care units (NICUs). The association between nursery design and nosocomial infections has not been delineated. We hypothesized that rates of colonization by methicillin-
Burnham, Carey-Ann D, Hamvas, Aaron, Julian, Samuel, Sellenriek, Patricia, Shannon, William D, Tarr, Phillip I, Warner, Barbara B   +6 more
core   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Primer Consenso Colombiano en Sepsis

Revista Colombiana de Cirugía, 2006
La sepsis, sepsis severa y el choque séptico tienen una incidencia alta y conllevan a una alta mortalidad, morbilidad y costos. Es por esto que la AMCI y la ACIN decidieron realizar un consenso de diagnóstico y tratamiento de sepsis con los siguientes ...
Marcos I. Restrepo, Carmelo Dueñas, Marco González, Guillermo Ortiz, Carlos Álvarez, Marcela Granados, Carlos Acosta, Arturo Arias, Luis H. Atehortúa, Rubén Camargo, Martín Carvajal, Gisela de la Rosa, Julio Durán, Juan L. Echeverri, Bladimir Gil, Carlos Hurtado, Ernesto Martínez, Carlos Rebolledo, Carlos Saavedra, Julio Sandoval, Julio Velandia, José A. Vélez, Juan D. Vélez, Representantes de los comités de la Asociación Colombiana de Medicina Intensiva y Cuidado Intensivo (AMCI) y la Asociación Colombiana de Infectología (ACIN)   +23 more
doaj  

Prognostic Value of International Normalized Ratio and Thrombocytopenia in Early Risk Stratification of Septic Patients

Biomedicines
Background/Objective: Coagulopathy is a hallmark of sepsis, associated with poor outcomes. Although platelet count has commonly been used for risk stratification, its prognostic value has remained limited.
Sofía Tejada, Andrés Giglio, Maria Aranda, Antonia Socias, Alberto del Castillo, Joana Mena, Sara Franco, Maria Ortega, Yasmina Nieto, Marcio Borges-Sa   +9 more
doaj   +1 more source

Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis. [PDF]

, 2019
Sepsis claims an estimated 30 million episodes and 6 million deaths per year, and treatment options are rather limited. Human neutrophil peptides 1-3 (HNP1-3) are the most abundant neutrophil granule proteins but their neutrophil content varies because ...
Chen, QiXing, Fang, XiangMing, Fu, WeiTao, Ganz, Tomas, Han, Feng, Hou, JinChao, Hou, TingJun, Linzmeier, Rose, Nemeth, Elizabeta, Shu, Qiang, Yang, Yang, Yin, YiXuan, Zeng, CongLi   +12 more
core   +1 more source

Association of Chorioamnionitis with Aberrant Neonatal Gut Colonization and Adverse Clinical Outcomes. [PDF]

, 2016
ObjectiveChorioamnionitis (inflammation of the placenta and fetal membranes) and abnormal gastrointestinal colonization have been associated with an increased risk of sepsis and death in preterm infants, but whether chorioamnionitis causes abnormal ...
Ambalavanan, Namasivayam, Kallapur, Suhas G, Morrow, Ardythe L, Puri, Kriti, Schibler, Kurt R, Taft, Diana H   +5 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Circulating NETs enable early identification of thrombotic risk in sepsis at emergency care onset

Frontiers in Immunology
IntroductionSepsis involves a dysregulated host response to infection and is frequently complicated by coagulopathy, contributing to organ dysfunction and mortality.
Sofia Tejada, Antonio Clemente, Antonio Clemente, Antonia Socias, Antonia Socias, Maria Aranda, Maria Aranda, Alberto del Castillo, Alberto del Castillo, Joana Mena, Joana Mena, Joana Mª Ribas, Joana Mª Ribas, Luisa Martín, Luisa Martín, Karla Milagritos Llerena, Karla Milagritos Llerena, María Magdalena Arellano, María Magdalena Arellano, Miguel Agudo, Roberto de la Rica, Roberto de la Rica, Marcio Borges, Marcio Borges   +23 more
doaj   +1 more source