Results 61 to 70 of about 536,044 (309)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Prognostic Value of International Normalized Ratio and Thrombocytopenia in Early Risk Stratification of Septic Patients

Biomedicines
Background/Objective: Coagulopathy is a hallmark of sepsis, associated with poor outcomes. Although platelet count has commonly been used for risk stratification, its prognostic value has remained limited.
Sofía Tejada, Andrés Giglio, Maria Aranda, Antonia Socias, Alberto del Castillo, Joana Mena, Sara Franco, Maria Ortega, Yasmina Nieto, Marcio Borges-Sa   +9 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The role of peroxisome proliferator-activated receptor gamma during sepsis-induced lymphopenia [PDF]

, 2011
Sepsis is one of the most common diseases on intensive care units all over the world and accounts there for the highest mortality rate. One of the hallmarks of sepsis is an accelerated T-cell apoptosis, resulting in a compromised immune state with the ...
Schmidt, Martina
core  

Predictors of Positive Blood Culture and Deaths Among Neonates with Suspected Neonatal Sepsis in a Tertiary Hospital, Mwanza-Tanzania. [PDF]

, 2010
Neonatal sepsis is a significant cause of morbidity and mortality in neonates. Appropriate clinical diagnosis and empirical treatment in a given setting is crucial as pathogens of bacterial sepsis and antibiotic sensitivity pattern can considerably vary ...
Kamugisha, Erasmus, Jeremiah, Seni, Mwizamholya Damas L, Stephen E Mshana, Kamugisha Erasmus, Erasmus Kamugisha, Damas L Mwizamholya, Mshana Stephen E, Mwizamholya, Damas L, Kayange, Neema, Neema Kayange, Jeremiah Seni, Kayange Neema, Mshana, Stephen E, Seni Jeremiah   +14 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Major sepsis study confirms back to basics approach [PDF]

, 2014
In 2001 Rivers et al. published a landmark study in the New England Journal of Medicine showing that in a single centre, involving patients presenting to an emergency department with severe sepsis and septic shock, an early goal-directed therapy (EGDT ...
Nathwani, D.
core   +1 more source

Circulating NETs enable early identification of thrombotic risk in sepsis at emergency care onset

Frontiers in Immunology
IntroductionSepsis involves a dysregulated host response to infection and is frequently complicated by coagulopathy, contributing to organ dysfunction and mortality.
Sofia Tejada, Antonio Clemente, Antonio Clemente, Antonia Socias, Antonia Socias, Maria Aranda, Maria Aranda, Alberto del Castillo, Alberto del Castillo, Joana Mena, Joana Mena, Joana Mª Ribas, Joana Mª Ribas, Luisa Martín, Luisa Martín, Karla Milagritos Llerena, Karla Milagritos Llerena, María Magdalena Arellano, María Magdalena Arellano, Miguel Agudo, Roberto de la Rica, Roberto de la Rica, Marcio Borges, Marcio Borges   +23 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source