Results 61 to 70 of about 895,147 (354)

Primer Consenso Colombiano en Sepsis

Revista Colombiana de Cirugía, 2006
La sepsis, sepsis severa y el choque séptico tienen una incidencia alta y conllevan a una alta mortalidad, morbilidad y costos. Es por esto que la AMCI y la ACIN decidieron realizar un consenso de diagnóstico y tratamiento de sepsis con los siguientes ...
Marcos I. Restrepo, Carmelo Dueñas, Marco González, Guillermo Ortiz, Carlos Álvarez, Marcela Granados, Carlos Acosta, Arturo Arias, Luis H. Atehortúa, Rubén Camargo, Martín Carvajal, Gisela de la Rosa, Julio Durán, Juan L. Echeverri, Bladimir Gil, Carlos Hurtado, Ernesto Martínez, Carlos Rebolledo, Carlos Saavedra, Julio Sandoval, Julio Velandia, José A. Vélez, Juan D. Vélez, Representantes de los comités de la Asociación Colombiana de Medicina Intensiva y Cuidado Intensivo (AMCI) y la Asociación Colombiana de Infectología (ACIN)   +23 more
doaj  

Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis

The Scientific World Journal, 2014
Neonatal sepsis (NS) is an important cause of mortality in newborns and life-threatening disorder in infants. The meta-analysis was performed to investigate the diagnosis value of tumor necrosis factor-α (TNF-α) test in NS.
Bokun Lv, Jie Huang, Haining Yuan, Wenying Yan, Guang Hu, Jian Wang   +5 more
doaj   +1 more source

Presepsin is a novel highly effective sepsis marker (Review)

Сучасні медичні технології, 2020
In this review the most effective markers of septic process like Procalcitonin, C-reactive protein, and cytokines compared to the new marker – Presepsin (PSP) are analyzed.
S. D. Shapoval, I. L. Savon, L. V. Vasylevska, M. M. Sofilkanych   +3 more
doaj   +1 more source

Leukocyte Activation Profile Assessed by Raman Spectroscopy Helps Diagnosing Infection and Sepsis

Critical Care Explorations, 2021
Objectives:. Leukocytes are first responders to infection. Their activation state can reveal information about specific host immune response and identify dysregulation in sepsis.
Anuradha Ramoji, PhD, Daniel Thomas-Rüddel, MD, Oleg Ryabchykov, PhD, Michael Bauer, MD, Natalie Arend, MSc, Evangelos J. Giamarellos-Bourboulis, MD, Jesper Eugen-Olsen, PhD, Michael Kiehntopf, MD, Thomas Bocklitz, PhD, Jürgen Popp, PhD, Frank Bloos, MD, PhD, Ute Neugebauer, PhD   +11 more
doaj   +1 more source

Effect of a machine learning-based severe sepsis prediction algorithm on patient survival and hospital length of stay: a randomised clinical trial. [PDF]

, 2017
IntroductionSeveral methods have been developed to electronically monitor patients for severe sepsis, but few provide predictive capabilities to enable early intervention; furthermore, no severe sepsis prediction systems have been previously validated in
Barton, Christopher W, Das, Ritankar, Feldman, Mitchell D, Mataraso, Samson J, Shimabukuro, David W   +4 more
core   +2 more sources

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Preterm birth skews the developmental trajectory of myeloid-derived suppressor cells in the first 48 hours of life: single-cell transcriptomics and inferred intercellular communication

Molecular Medicine
Background Prematurity is a leading cause of neonatal and childhood mortality, with infections driving early deaths. Innate immunity provides frontline defense after birth and is shaped in part by myeloid-derived suppressor cells (MDSCs).
Miguel Hernández-Ríos, Jaimar Rincon, Leandro Balzano-Nogueira, Valerie Polcz, Dayuan Wang, Whitman Wiggins, Christine Rodhouse, Athina Yoham, Feifei Xiao, Ricardo Ungaro, Marvin Dirain, Lyle Moldawer, Robert Maile, Guoshuai Cai, Philip Efron, Shawn Larson   +15 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Prognostic Value of International Normalized Ratio and Thrombocytopenia in Early Risk Stratification of Septic Patients

Biomedicines
Background/Objective: Coagulopathy is a hallmark of sepsis, associated with poor outcomes. Although platelet count has commonly been used for risk stratification, its prognostic value has remained limited.
Sofía Tejada, Andrés Giglio, Maria Aranda, Antonia Socias, Alberto del Castillo, Joana Mena, Sara Franco, Maria Ortega, Yasmina Nieto, Marcio Borges-Sa   +9 more
doaj   +1 more source

Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis. [PDF]

, 2019
Sepsis claims an estimated 30 million episodes and 6 million deaths per year, and treatment options are rather limited. Human neutrophil peptides 1-3 (HNP1-3) are the most abundant neutrophil granule proteins but their neutrophil content varies because ...
Chen, QiXing, Fang, XiangMing, Fu, WeiTao, Ganz, Tomas, Han, Feng, Hou, JinChao, Hou, TingJun, Linzmeier, Rose, Nemeth, Elizabeta, Shu, Qiang, Yang, Yang, Yin, YiXuan, Zeng, CongLi   +12 more
core   +1 more source